Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the determination of leuprolide in human serum

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 27, 2009, Pages 3194-3200

  Zhan, Yan ^a   Chen, Xiaoyan ^a   Zhao, Xiaohua ^a   Zhong, Dafang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Leuprolide; Liquid chromatography tandem mass spectrometry; Pharmacokinetics

Indexed keywords

ANALYTES; ANALYTICAL COLUMNS; ANALYTICAL METHOD; CLINICAL PHARMACOKINETICS; HUMAN SERUM; INDUCED PROTEINS; INTER-ASSAY PRECISION; INTERNAL STANDARDS; LC-MS/MS; LEUPROLIDE; LINEAR RANGE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; MOBILE PHASE; MOBILE-PHASE COMPOSITION; POSITIVE ELECTROSPRAY IONIZATION; PROPIONIC ACIDS; RELATIVE ERRORS; RELATIVE STANDARD DEVIATION (R.S.D.); SELECTIVE REACTION MONITORING; SENSITIVE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; SERUM SAMPLES; SOLID-PHASE EXTRACTION; TRIPLE QUADRUPOLE;

ACETONITRILE; AMINES; AMINO ACIDS; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; FATTY ACIDS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METHANOL; ORGANIC ACIDS; PHARMACOKINETICS; STANDARDS;

EXTRACTION;

ACETONITRILE; LEUPRORELIN; METHANOL; PROPIONIC ACID; WATER;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; CHINESE; CONTROLLED STUDY; DRUG BLOOD LEVEL; ELECTROSPRAY; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; LEUPROLIDE; LINEAR MODELS; MALE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 69749090736     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.08.023     Document Type: Article

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