Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase

Tetrahedron

Volumn 65, Issue 41, 2009, Pages 8486-8492

  Pomeisl, Karel ^a   Holý, Antonín ^a   Pohl, Radek ^a   Horská, Květoslava ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Acyclic nucleoside phosphonates; Human thymidine phosphorylase; Pyrimidine; SD lymphoma; Suzuki coupling; Suzuki Miyaura reaction; Thymidine phosphorylase; Uracil

Indexed keywords

5 BROMO 4 (PHOSPHONOMETHOXY) 2,6 DIBUTOXYPYRIMIDINE; ACYCLIC NUCLEOSIDE; PALLADIUM; PHOSPHONIC ACID DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANIMAL CELL; ARTICLE; ARYLATION; CONTROLLED STUDY; DEHALOGENATION; DEPROTECTION REACTION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; SOLVATION; SUZUKI REACTION;

EID: 69749089248     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2009.08.039     Document Type: Article

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