Elevated levels of intestinal inflammation in Clostridium difficile infection associated with fluoroquinolone-resistant C. difficile

Journal of Hospital Infection

Volumn 73, Issue 2, 2009, Pages 185-187

  Pawlowski, S W ^a   Archbald Pannone, L ^b   Carman, R J ^c   Alcantara Warren, C ^a   Lyerly, D ^c   Genheimer, C W ^c   Gerding, D N ^d,e   Guerrant, R L ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c TECHLAB INC   (United States)

^d HINES VA HOSPITAL   (United States)

^e LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; GLUTAMATE DEHYDROGENASE; LACTOFERRIN; MOXIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIAL STRAIN; BASE PAIRING; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; DISEASE SEVERITY; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES ANALYSIS; GENE DELETION; HUMAN; LETTER; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERASE CHAIN REACTION; UNITED STATES; UNIVERSITY HOSPITAL;

ANTI-BACTERIAL AGENTS; AZA COMPOUNDS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; DRUG RESISTANCE, BACTERIAL; FECES; FLUOROQUINOLONES; HUMANS; INFLAMMATION; INTESTINES; LACTOFERRIN; MICROBIAL SENSITIVITY TESTS; QUINOLINES;

EID: 69749088498     PISSN: 01956701     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhin.2009.05.013     Document Type: Letter

References (6)

1. Pepin J., Valiquette L., Alary M.E., et al. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. Can Med Assoc J 171 (2004) 466-472
2. Muto C.A., Pokrywka M., Shutt K., et al. A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use. Infect Control Hosp Epidemiol 26 (2005) 273-280
3. McEllistrem M.C., Carman R.J., Gerding D.N., Genheimer C.W., and Zheng L. A hospital outbreak of Clostridium difficile disease associated with isolates carrying binary toxin genes. Clin Infect Dis 40 (2005) 265-272
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6. Steiner T.S., Flores C.A., Pizarro T.T., and Guerrant R.L. Fecal lactoferrin, interleukin-1beta, and interleukin-8 are elevated in patients with severe Clostridium difficile colitis. Clin Diagn Lab Immunol 4 (1997) 719-722