Testicular gene expression profiling following 2-methoxyethanol and 2-ethoxyethanol exposure in male rats reveals abnormal expression of the actin binding protein cortactin in degenerating spermatocytes

Toxicology Letters

Volumn 190, Issue 2, 2009, Pages 193-201

  Tonkin, Elizabeth G ^a   Cooper, Matthew ^a   Lollini, Lance O ^a   Day Lollini, Patricia A ^a   Allard, John ^b   Kolaja, Kyle L ^a   Platz, Stefan J ^a   Chanda, Sushmita M ^a  

^a Roche Palo Alto ^*  (United States)

^b Roche Palo Alto   (United States)

Author keywords

2 Ethoxyethanol; 2 Methoxyethanol; Cortactin; Gene expression profiling; Testis; Toxicity

Indexed keywords

2 ETHOXYETHANOL; 2 METHOXYETHANOL; ACTIN BINDING PROTEIN; CORTACTIN; PROTEIN KINASE; RNA; WT1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL CYCLE; CELL DEATH; CELL DEGENERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVITY; EXPOSURE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MEIOSIS; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SPERMATOCYTE; TESTIS DISEASE;

ANIMALS; CORTACTIN; ETHYLENE GLYCOLS; GENE EXPRESSION; GENE EXPRESSION PROFILING; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SPERMATOCYTES; TERATOGENS; TESTIS; WT1 PROTEINS;

ANIMALIA; RATTUS;

EID: 69649098037     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.07.017     Document Type: Article

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