A new dynamic porcine model of meningococcal shock

Shock

Volumn 32, Issue 3, 2009, Pages 302-309

  Nielsen, Erik Waage ^a,b   Hellerud, Bernt Christian ^c,d   Thorgersen, Ebbe Billmann ^c   Castellheim, Albert ^c   Pharo, Anne ^c   Lindstad, Julie ^c   Tønnessen, Tor Inge ^c   Brandtzaeg, Petter ^d   Mollnes, Tom E ^a,b,c  

^a Norland Hospital   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Cytokines; Neisseria meningitidis; Porcine; Pulmonary hypertension; Sepsis; Shock; Vascular leakage

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; OXYGEN; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL PIG; EXTRAVASATION; GENERAL ANESTHESIA; HEMATOCRIT; HUMAN; LUNG ARTERY PRESSURE; MENINGOCOCCEMIA; NEISSERIA MENINGITIDIS; NEUTROPHIL COUNT; NONHUMAN; PEAK INSPIRATORY FLOW; SYSTEMIC VASCULAR RESISTANCE;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MENINGOCOCCAL INFECTIONS; NEISSERIA MENINGITIDIS; RANDOM ALLOCATION; SHOCK, SEPTIC; SWINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 69549138443     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31819c37be     Document Type: Article

References (35)

1. Stephens DS, Greenwood B, Brandtzaeg P: Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet 369:2196-2210, 2007. (Pubitemid 46977462)
2. Brandtzaeg P: Pathogenesis and pathophysiology of invasive meningococcal disease. In Frosch M, Maiden M, eds. Meningococcal Disease. Pathogenicity and Prevention. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co, 427-480, 2006.
3. Apicella MA: Neisseria meningitidis. In Dolin R, Bennett JE, Mandell GL, Douglas RG, eds. Principles and Practice of Infectious Diseases. Philadelphia, PA: Elsevier Churchill Livingstone, 2498-2513, 2005.
4. Pathan N, Faust SN, Levin M: Pathophysiology of meningococcal meningitis and septicaemia. Arch Dis Child 88:601-607, 2003.
5. van Deuren M, Brandtzaeg P, van der Meer JW: Update on meningococcal disease with emphasis on pathogenesis and clinical management. Clin Microbiol Rev 13:144-166, 2000. (Pubitemid 30039347)
6. de Kleijn ED, Hazelzet JA, Kornelisse RF, de Groot R: Pathophysiology of meningococcal sepsis in children. Eur J Pediatr 157:869-880, 1998.
7. Brandtzaeg P, Kierulf P, Gaustad P, Skulberg A, Bruun JN, Halvorsen S, Sorensen E: Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disease. J Infect Dis 159:195-204, 1989. (Pubitemid 19049357)
8. Brandtzaeg P, Bryn K, Kierulf P, Ovstebo R, Namork E, Aase B, Jantzen E: Meningococcal endotoxin in lethal septic shock plasma studied by gas chromatography, mass-spectrometry, ultracentrifugation, and electron microscopy. J Clin Invest 89:816-823, 1992.
9. Ovstebo R, Brandtzaeg P, Brusletto B, Haug KBF, Lande K, Hoiby EA, Kierulf P: Use of robotized DNA isolation and real-time PCR to quantify and identify close correlation between levels of Neisseria meningitidis DNA and lipopolysaccharides in plasma and cerebrospinal fluid from patients with systemic meningococcal disease. J Clin Microbiol 42:2980-2987, 2004. (Pubitemid 38938046)
10. Emonts M, Hazelzet JA, de Groot R, Hermans PW: Host genetic determinants of Neisseria meningitidis infections. Lancet Infect Dis 3:565-577, 2003. (Pubitemid 37064536)
11. Sjoholm AG, Braconier JH, Soderstrom C: Properdin deficiency in a family with fulminant meningococcal infections. Clin Exp Immunol 50:291-297, 1982.
12. Gorringe AR, Reddin KM, Funnell SG, Johansson L, Rytkonen A, Jonsson AB: Experimental disease models for the assessment of meningococcal vaccines. Vaccine 23:2214-2217, 2005. (Pubitemid 40341454)
13. Swindle MM, Smith AC: Comparative anatomy and physiology of the pig. Scand J Lab Anim Sci 25:1-10, 1998.
14. Hazelzet JA, Stubenitsky R, Petrov AB, van Wieringen GW, van der Voort E, Hess J, Hop WC, Thijs LG, Duncker DJ, Poolman JT, et al.: Cardiovascular aspects of experimental meningococcal sepsis in young and older awake piglets: age-related differences. Shock 12:145-154, 1999.
15. Sprong T, Brandtzaeg P, Fung M, Pharo AM, Hoiby EA, Michaelsen TE, Aase A, van der Meer JWM, van Deuren M, et al.: Inhibition of C5a-induced inflammation with preserved C5b-9-mediated bactericidal activity in a human whole blood model of meningococcal sepsis. Blood 102:3702-3710, 2003. (Pubitemid 37409391)
16. Julien M, Flick MR, Hoeffel JM, Murray JF: Accurate reference measurement for postmortem lung water. J Appl Physiol 56:248-253, 1984.
17. Barboni B, Turriani M, Galeati G, Spinaci M, Bacci ML, Forni M, Mattioli M: Vascular endothelial growth factor production in growing pig antral follicles. Biol Reprod 63:858-864, 2000. (Pubitemid 30659283)
18. Mollnes TE, Lea T, Froland SS, Harboe M: Quantification of the terminal complement complex in human plasma by an enzyme-linked immunosorbent assay based on monoclonal antibodies against a neoantigen of the complex. Scand J Immunol 22:197-202, 1985. (Pubitemid 15016794)
19. Thorgersen EB, Ghebremariam YT, Thurman JM, Fung M, Nielsen EW, Holers VM, Kotwal GJ, Mollnes TE: Candidate inhibitors of porcine complement. Mol Immunol 44:1827-1834, 2007.
20. Mollnes TE, Redl H, Hogasen K, Bengtsson A, Garred P, Speilberg L, Lea T, Oppermann M, Gotze O, Schlag G: Complement activation in septic baboons detected by neoepitope- specific assays for C3b/iC3b/C3c, C5a and the terminal C5b-9 complement complex (TCC). Clin Exp Immunol 91:295-300, 1993.
21. Klosterhalfen B, Horstmann-Jungemann K, Vogel P, Flohe S, Offner F, Kirkpatrick CJ, Heinrich PC: Time course of various inflammatory mediators during recurrent endotoxemia. Biochem Pharmacol 43:2103-2109, 1992.
22. Galanos C, Freudenberg MA, Reutter W: Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci U S A 76:5939-5943, 1979. (Pubitemid 10216692)
23. Hackett SJ, Guiver M, Marsh J, Sills JA, Thomson APJ, Kaczmarski EB, Hart CA: Meningococcal bacterial DNA load at presentation correlates with disease severity. Arch Dis Child 86:44-46, 2002. (Pubitemid 36307629)
24. Clavijo LC, Carter MB, Matheson PJ, Wills-Frank LA, Wilson MA, Wead WB, Garrison RN: Platelet-activating factor and bacteremia-induced pulmonary hypertension. J Surg Res 88:173-180, 2000.
25. Wanecek M, Rudehill A, Hemsen A, Lundberg JM, Weitzberg E: The endothelin receptor antagonist, bosentan, in combination with the cyclooxygenase inhibitor, diclofenac, counteracts pulmonary hypertension in porcine endotoxin shock. Crit Care Med 25:848-857, 1997. (Pubitemid 27249163)
26. Brain JD, Molina RM, DeCamp MM, Warner AE: Pulmonary intravascular macrophages: their contribution to the mononuclear phagocyte system in 13 species. Am J Physiol Lung Cell Mol Physiol 276:L146-L154, 1999.
27. Winkler GC: Pulmonary intravascular macrophages in domestic animal species: review of structural and functional properties. Am J Anat 181:217-234, 1988.
28. Waage A, Halstensen A, Espevik T: Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet 1:355-357, 1987. (Pubitemid 17010024)
29. Waage A, Brandtzaeg P, Halstensen A, Kierulf P, Espevik T: The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome. J Exp Med 169:333-338, 1989. (Pubitemid 19035565)
30. Halstensen A, Ceska M, Brandtzaeg P, Redl H, Naess A, Waage A: Interleukin-8 in serum and cerebrospinal fluid from patients with meningococcal disease. J Infect Dis 167:471-475, 1993. (Pubitemid 23036457)
31. Derkx B, Marchant A, Goldman M, Bijlmer R, van Deventer S: High levels of interleukin-10 during the initial phase of fulminant meningococcal septic shock. J Infect Dis 171:229-232, 1995.
32. van Deuren M, van der Ven-Jongekrijg J, Bartelink AK, van Dalen R, Sauerwein RW, van der Meer JW: Correlation between proinflammatory cytokines and antiinflammatory mediators and the severity of disease in meningococcal infections. J Infect Dis 172:433-439, 1995.
33. Hazelzet JA, Kornelisse RF, van der Pouw Kraan TC, Joosten KF, van der Voort E, van Mierlo G, Suur MH, Hop WC, de Groot R, Hack CE: Interleukin 12 levels during the initial phase of septic shock with purpura in children: relation to severity of disease. Cytokine 9:711-716, 1997.
34. Brandtzaeg P, Osnes L, Ovstebo R, Joo GB, Westvik AB, Kierulf P: Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes. J Exp Med 184:51-60, 1996. (Pubitemid 26247214)
35. Rojahn A, Brusletto B, Ovstebo R, Haug KB, Kierulf P, Brandtzaeg P: Does granulocyte colony-stimulating factor ameliorate the proinflammatory response in human meningococcal septic shock? Crit Care Med 36:2583-2589, 2008.