Don't Squeeze Hypofractionated Schedules into Too-Short Overall Times

International Journal of Radiation Oncology Biology Physics

Volumn 75, Issue 2, 2009, Pages 323-325

  Fowler, Jack ^a   King, Christopher R ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER RADIOTHERAPY; EDITORIAL; GONAD DOSE; HUMAN; PRIORITY JOURNAL; PROSTATE CANCER; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION INJURY; RECTUM MUCOSA; TREATMENT DURATION;

CELL PROLIFERATION; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; HEAD AND NECK NEOPLASMS; HUMANS; INTESTINAL MUCOSA; MALE; PROSTATIC NEOPLASMS; RADIATION INJURIES; RADIATION TOLERANCE; RECTUM; RELATIVE BIOLOGICAL EFFECTIVENESS; TIME FACTORS;

EID: 69549138190     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.06.022     Document Type: Editorial

References (15)

1. Fowler J.F., Harari P.M., Leborgne F., and Leborgne J.H. Acute radiation reactions in oral and pharyngeal mucosa: Tolerable levels in altered fractionation schedules. Radiother Oncol 69 (2003) 161-168
2. Steel G.G. Basic clinical radiobiology. 3rd ed (2002), Arnold, London p. 25, 31, 108
3. Bentzen S.M., Saunders M.I., Dische S., et al. Radiotherapy-related early morbidity in head and neck cancer: Quantitative clinical radiobiology as deduced from the CHART trial. Radiother Oncol 60 (2001) 123-135
4. Dörr W., Hamilton C.S., Boyd T., et al. Radiation-induced changes in cellularity and proliferation in human oral mucosa. Int J Radiat Oncol Biol Phys 52 (2002) 911-917
5. Withers H.R., Taylor J.M., and Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 27 (1988) 131-146
6. Perez C.A., Michalski J., Mansur D., et al. Impact of elapsed treatment time on outcome of external-beam radiation therapy for localized carcinoma of the prostate. Cancer J 10 (2004) 349-356
7. Fowler J.F. Practical time-dose evaluation, or how to stop worrying and love LQ. In: Levitt S.H., Purdy J.A., Perez C.A., et al. (Eds). Technical basis of radiation therapy. 4th revised ed (2006), Springer-Verlag, Heidelberg 3-31
8. Huang E.H., Pollack A., Levy L., et al. Late rectal toxicity: dose-volume effects of conformal radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 54 (2002) 1314-1321
9. Vargas C., Martinez A., Kestin L.L., et al. Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy. Int J Radiat Oncol Biol Phys 62 (2005) 1297-1308
10. Peeters S.T.H., Heemsbergen W.D., van Putten W.L.J., et al. Acute and late complications after radiotherapy for prostate cancer: Results of a multicenter randomized trial comparing 68 Gy to 78 Gy. Int J Radiat Oncol Biol Phys 61 (2005) 1019-1034
11. Martin J.M., Bayley A., Catton C.N., et al. A prospective study of hypofractionated radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 66 (2006) S35-S36
12. Dearnaley D, Norman A, Syndikus I, et al. Conventional vs hypofractionated high dose intensity modulated radiotherapy for prostate cancer (CHHIP)-a phase III multicentre trial. Preliminary report on acute and late toxicity (ISRCTNN 97182923) (Abstr.). Presented at the 2007 American Society of Clinical Oncology Prostate Cancer Symposium, February 22-24, 2007, Orlando, Florida.
13. Arcangeli S., Strigari L., Soete G., et al. Clinical and dosimetric predictors of acute toxicity after a 4-week hypofractionated external beam radiotherapy regimen for prostate cancer: Results from a multicentric prospective trial. Int J Radiat Oncol Biol Phys 73 (2009) 39-45
14. Leborgne F., and Fowler J.F. Acute toxicity after hypofractionated conformal radiotherapy for localized prostate cancer: Nonrandomized contemporary comparison with standard fractionation. Int J Radiat Oncol Biol Phys 72 (2008) 770-776
15. King C.R., Brooks J.D., Gill H., et al. Stereotactic body radiotherapy for localized prostate cancer: Interim results of a prospective phase II clinical trial. Int J Radiat Oncol Biol Phys 73 (2009) 1043-1048