The negative inotropic action of canrenone is mediated by L-type calcium current blockade and reduced intracellular calcium transients

British Journal of Pharmacology

Volumn 158, Issue 2, 2009, Pages 580-587

  Costa, A R ^a,d   Torres, L B ^a   Medei, E ^b   Ricardo, R A ^c   Franca J P ^a   Smaili, S ^a   Nascimento, J H M ^b   Oshiro, M E M ^a   Bassani, J W M ^c   Ferreira, A T ^a   Tucci, P J F ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Calcium; Calcium channel; Canrenone; Sarcoplasmic reticulum; Spironolactone

Indexed keywords

CAFFEINE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM ION; CANRENONE; DRUG METABOLITE; SPIRONOLACTONE;

AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CONTROLLED STUDY; DIASTOLE; DOSE TIME EFFECT RELATION; DRUG MECHANISM; HEART FAILURE; HEART LEFT VENTRICLE MUSCLE; HEART MUSCLE CONTRACTILITY; HEART PAPILLARY MUSCLE; INOTROPISM; MALE; MATHEMATICAL ANALYSIS; MEMBRANE ELECTROPHYSIOLOGY; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SARCOPLASMIC RETICULUM; STEADY STATE;

ALDOSTERONE ANTAGONISTS; ANIMALS; CAFFEINE; CALCIUM; CALCIUM CHANNELS, L-TYPE; CANRENONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HOMEOSTASIS; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PAPILLARY MUSCLES; RATS; RATS, WISTAR; SARCOPLASMIC RETICULUM; SPIRONOLACTONE;

EID: 69549129522     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00329.x     Document Type: Article

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