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Volumn 6, Issue 5, 2009, Pages 381-383

Regioselective three-component synthesis of indolylpyrazolo[3, 4-b]pyridines induced by microwave and under solvent-free conditions

(7) Quiroga, Jairo a Trilleras, Jorge a Sánchez, Ana Isabel a Insuasty, Braulio a Abonía, Rodrigo a Nogueras, Manuel b Cobo, Justo b

a UNIVERSIDAD DEL VALLE (Colombia)

b UNIVERSITY OF JAÉN (Spain)

Author keywords

3 (1H indol 3 yl) 3 oxopropanenitrile; 5 Aminopyrazole; Benzaldehyde; Indolylpyrazolo 3, 4 b pyridine; Microwave; Solvent free procedure; Three component reaction

Indexed keywords

EID: 69549121971 PISSN: 15701786 EISSN: None Source Type: Journal
DOI: 10.2174/157017809788681284 Document Type: Article

Times cited : (19)

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25
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- General procedure for the preparation of 1-(1H-indol-3-yl)-3-aryl-2- cyano-1-propenone 6 under microwave irradiation. Microwave experiment was carried out using a focused microwave reactor (CEM Discover TM). The 3-(1H-indol-3-yl)-3-oxopropanenitrile 5 (0.5 mmol) was mixed with equimolar amounts of aromatic aldehydes 2 (0.5 mmol). The mixture was exposed to microwave radiation at a 200 C with a maximum power of 300 W for 6 min. The solid was dissolved in hot ethanol-DMF solution (2: 1)
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26
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