A novel, promoter-based, target-specific assay identifies 2-deoxy-d-glucose as an inhibitor of globotriaosylceramide biosynthesis

FEBS Journal

Volumn 276, Issue 18, 2009, Pages 5191-5202

  Okuda, Tetsuya ^a   Furukawa, Koichi ^b   Nakayama, Ken Ichi ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Fabry disease; Glycosphingolipid; Glycosyltransferase; Hemolytic uremic syndrome; Promoter

Indexed keywords

CYTOKINE; DEOXYGLUCOSE; GLOBOTRIAOSYLCERAMIDE; GLOBOTRIAOSYLCERAMIDE SYNTHASE; LACTOSYLCERAMIDE; LUCIFERASE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CARBOHYDRATE ANALYSIS; CELL SURFACE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; FUSION GENE; GENE CONSTRUCT; GENETIC TRANSCRIPTION; HEMOLYTIC UREMIC SYNDROME; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRECURSOR; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; SCREENING;

CELLS, CULTURED; DEOXYGLUCOSE; ENZYME INHIBITORS; GALACTOSYLTRANSFERASES; HUMANS; P-GLYCOPROTEIN; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; TRIHEXOSYLCERAMIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 69449098610     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07215.x     Document Type: Article

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