Ionomycin, but not physiologic doses of epinephrine, stimulates skeletal muscle Interleukin-6 mRNA expression and protein release

Metabolism: Clinical and Experimental

Volumn 53, Issue 11, 2004, Pages 1492-1495

  Holmes, A G ^a   Watt, M J ^a   Carey, A L ^a   Febbraio, M A ^a  

^a RMIT UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BUFFER; CALCIUM IONOPHORE; INTERLEUKIN 6; IONOMYCIN; MESSENGER RNA;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; RAT STRAIN; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA EXTRACTION; SKELETAL MUSCLE; SOLEUS MUSCLE;

ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPINEPHRINE; GENE EXPRESSION REGULATION; INTERLEUKIN-6; IONOMYCIN; MALE; MUSCLE, SKELETAL; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 6944250873     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2004.05.015     Document Type: Article

References (24)

1. Febbraio M.A., Pedersen B.K. Muscle-derived interleukin-6 Mechanisms for activation and possible biological roles. FASEB J. 16:2002;1335-1347
2. Mohamed-Ali V., Goodrick S., Rawesh A., et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab. 82:1997;4196-4200
3. Vozarova B., Weyer C., Hanson K., et al. Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res. 9:2001;414-417
4. Carey A.L., Bruce C.R., Sacchetti M., et al. IL-6 and TNFα are not elevated in patients with type two diabetes Evidence that plasma IL-6 is related to fat mass and not insulin responsiveness. Diabetologia. 47:2004.;1029-1037
5. Pedersen B.K., Steensberg A., Keller P., et al. Muscle-derived interleukin-6 Lipolytic, anti-inflammatory and immune regulatory effects. Pflugers Arch. 446:2003;9-16
6. Febbraio M.A. Signaling pathways for IL-6 within skeletal muscle. Exerc Immunol Rev. 9:2003;34-39
7. Nieman D.C., Nehlsen-Canarella S.L., Fagoaga O.R., et al. Influence of mode and carbohydrate on the cytokine response to heavy exertion. Med Sci Sports Exerc. 30:1998;671-678
8. Nehlsen-Canarella S.L., Fagoaga O.R., Nieman D.C. Carbohydrate and the cytokine response to 2.5 hours of running. J Appl Physiol. 82:1997;1662-1667
9. Nieman D.C., Davis J.M., Henson D.A., et al. Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3 h run. J Appl Physiol. 94:2003;1917-1925
10. DeRijk R.H., Boelen A., Tilders F.J., et al. Induction of plasma interleukin-6 by circulating adrenaline in the rat. Psychoneuroendocrinology. 19:1994;155-163
11. Søndergaard S.R., Ostrowski K., Ullum H., et al. Changes in plasma levels of IL-6 and IL-1ra in response to adrenaline. Eur J Appl Physiol. 83:2000;95-98
12. Papanicolaou D.A., Petrides J.S., Tsigos C., et al. Exercise stimulates interleukin-6 secretion Inhibition by glucocorticoids and correlation with catecholamines. Am J Physiol. 271:1996;601-605
13. Helge J.W., Stallknecht B., Pedersen B.K., et al. The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle. J Physiol. 546:2003;299-305
14. Steensberg A., Toft A.D., Schjerling P., et al. Plasma interleukin-6 during strenuous exercise Role of epinephrine. Am J Physiol. 281:2001;1001-1004
15. Steensberg A., Febbraio M.A., Osada T., et al. Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. J Physiol. 537:2001;633-639
16. Keller C., Steensberg A., Pilegaard H., et al. Transcriptional activation of the IL-6 gene in human contracting skeletal muscle Influence of muscle glycogen content. FASEB J. 15:2001;2748-2750
17. Berridge M.J. Inositol triphosphate and calcium signalling. Nature. 361:1993;315-425
18. Ghosh A., Greenberg M.E. Calcium signalling in neurons Molecular mechanisms and cellular consequences. Science. 268:1995;239-247
19. 2+ dependent pathway. J Physiol. 539:2002;31. (abstr)
20. Passonneau J.V., Lauderdale V.R. A comparison of three methods of glycogen measurement in tissues. Anal Biochem. 60:1974;405-412
21. Harris R.C., Hultman E., Nordesjs L.O. Glycogen, glycolytic intermediates and high energy phosphates determines in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values. Scand J Clin Lab Invest. 33:1974;109-120
22. Starkie R.L., Arkinstal M.J., Koukoulas I., et al. Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA during exercise in humans. J Physiol. 533:2001;585-591
23. Febbraio M.A., Steensberg A., Starkie R.L., et al. Skeletal muscle interleukin-6 and tumor necrosis factor-alpha release in healthy subjects and patients with type 2 diabetes at rest and during exercise. Metabolism. 52:2003;939-944
24. Olson E.N., Williams R.S. Remodeling muscles with calcineurin. Bioessays. 22:2000;510-519