Comparative pharmacodynamics and plasma concentrations of d-threo-methylphenidate hydrochloride after single doses of d-threo- methylphenidate hydrochloride and d,l-threo-methylphenidate hydrochloride in a double-blind, placebo-controlled, crossover laboratory school study in children with attention-deficit/hyperactivity disorder

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 43, Issue 11, 2004, Pages 1422-1429

  Quinn, Declan ^a,g,h,i   Wigal, Sharon ^{b,g,k,l,m,n,o,p,q}   Swanson, James ^{b,g,j,k,l,m,n,o,p,q}   Hirsch, Sharon ^{c,l,m,n,o,p,q}   Ottolini, Yvonne ^b   Dariani, Maghsoud ^d,m,r,s   Roffman, Mark ^e,h,o,t,u,v   Zeldis, Jerome ^d,h,o,w,x   Cooper, Thomas ^f,y  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d CELGENE CORPORATION   (United States)

^e MRCS   (United States)

^f NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^g JANSSEN RESEARCH AND DEVELOPMENT   (United States)

^h Janssen ^*

ⁱ Shire Development   (United States)

^j Celltech   (United Kingdom)

^k Alza   (United States)

^l McNeil Consum Specialty Pharmaceut   (United States)

^m NOVARTIS PHARMA AG   (Switzerland)

ⁿ Shire US Inc   (United States)

^o Immuno Oncology Translational Development   (United States)

^p Cephalon   (United States)

^q ELI LILLY AND COMPANY   (United States)

^r Semorex Inc

^s Focus Pharmaceuticals Inc

^t ClinSearch

^u Focus Pharmaceuticals Inc ^*  (United States)

^v MRCS

^w JOHNSON AND JOHNSON   (United States)

^x Merck

^y BRISTOL MYERS SQUIBB   (United States)

more..

Author keywords

Attention deficit hyperactivity disorder; d,l methylphenidate; d methylphenidate; Pediatric; Stimulant

Indexed keywords

DEXMETHYLPHENIDATE; METHYLPHENIDATE; PLACEBO;

AGITATION; ANXIETY DISORDER; ARTICLE; ATTENTION DEFICIT DISORDER; BLOOD PRESSURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSSOVER PROCEDURE; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DYSKINESIA; DYSPEPSIA; FATIGUE; HEADACHE; HUMAN; ISOMER; LABORATORY; MALE; MATHEMATICS; MENTAL PERFORMANCE; MICTURITION DISORDER; MULTICENTER STUDY; NERVOUSNESS; PRIORITY JOURNAL; PULSE RATE; RACEMIC MIXTURE; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SIDE EFFECT; SINGLE DRUG DOSE; SYMPTOM; TIC; TREATMENT OUTCOME;

EID: 6944229513     PISSN: 08908567     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.chi.0000140455.96946.2b     Document Type: Article

References (19)

1. American Psychiatric Association (1994), Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV). Washington, DC: American Psychiatric Association
2. Aoyama T, Kotaki H, Honda Y, Nakagawa F (1990), Kinetic analysis of enantiomers of threo-methylphenidate and its metabolite in two healthy subjects after oral administration as determined by a gas chromatographic-mass spectrometric method. J Pharm Sci 79:465-469
3. Greenhill LL, Swanson JM, Vitiello B et al. (2001), Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trial. J Am Acad Child Adolesc Psychiatry 40:180-187
4. Jadad AR, Booker L, Gauld M et al. (1999), The treatment of attention-deficit hyperactivity disorder: an annotated bibliography and critical appraisal of published systematic reviews and metaanalyses. Can J Psychiatry 44:1025-1035
5. Lim HK, Hubbard JW, Midha KK (1986), Development of enantioselective gas chromatographic quantitation assay for dl-threo-methylphenidate in biological fluids. J Chromatogr 378:109-123
6. MTA Cooperative Group (1999), A 14-month randomized clinical trial of treatment strategies for attention deficit hyperactivity disorder. Arch Gen Psychiatry 56:1073-1086
7. Patrick KS, Caldwell RW, Ferris RM, Breese GR (1987), Pharmacology of the enantiomers of threo-methylphenidate. J Pharmacol Exp Ther 241:152-158
8. Shaffer D, Fisher P, Lucas C, Dulcan M, Schwab-Stone ME (2000), NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences, from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry 39:28-38
9. Srivinas NR, Hubbard JW, Quinn D, Midha KK (1992), Enantioselective pharmacokinetics and pharmacodynamics of dl-threo-methylphenidate in children with attention deficit hyperactivity disorder. Clin Pharmacol Ther 52:561-568
10. Srinivas NR, Quinn D, Hubbard JW, Midha KK (1987), Stereoselective disposition of methylphenidate in children with attention-deficit disorder. J Pharmacol Exp Ther 241:300-306
11. Swanson J, Lerner M, Wigal T et al. (2002), The use of a laboratory school protocol to evaluate concepts about efficacy and side effects of new formulations of stimulant medications. J Atten Disord 6:S73-S88
12. Swanson JM (1992), School Based Assessments and Interventions for ADHD Students. Irvine, CA: KC Publishing
13. Swanson JM, Agler D, Fineberg E et al. (1999), University of California, Irvine. Laboratory School Protocol for Pharmacokinetic and Pharmacodynamic Studies. In: Ritalin: Theory and Practice, 2nd ed., Greenhill L, Osman B, eds. New York: Mary Ann Liebert, Inc. Publishers, pp 405-430
14. Swanson JM, Kraemer HC, Hinshaw SP et al. (2001), Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment. J Am Acad Child Adolesc Psychiatry 40:168-179
15. Swanson JM, Wigal S, Greenhill LL et al. (1998), Analog classroom assessment of Adderall in children with ADHD. J Am Acad Child Adolesc Psychiatry 37:519-526
16. Swanson JM, Wigal SB, Wigal T et al., the COMACS Study Group (2004), A comparison of once-daily extended-release methylphenidate formulations in children with attention-deficit/hyperactivity disorder in the laboratory school (the COMACS study). Pediatrics 113:206-216
17. Wigal SB, Gupta S, Guinta D, Swanson JM (1998), Reliability and validity of the SKAMP rating scale in a laboratory school setting. Psychopharmacol Bull 34:47-53
18. Wigal S, Swanson JM, Feifel D et al. (2004), A double-blind, placebo-controlled trial of dexmethylphenidate hydrochloride and d,l-threo-methylphenidate hydrochloride in children with attention-deficit/ hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 43:1406-1414.
19. Wilens TE, Biederman J (1992), The stimulants. Psychiatr Clin North Am 15:191-222