Elevated Testosterone and Hypergonadotropism in Active Adolescents of Normal Weight with Oligomenorrhea

Journal of Pediatric and Adolescent Gynecology

Volumn 22, Issue 5, 2009, Pages 323-327

  Singer, K ^a   Rosenthal, A ^a   Kasa Vubu, J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ESTRADIOL; ESTROGEN; FOLLITROPIN; LUTEINIZING HORMONE; PROGESTERONE; TESTOSTERONE;

ADOLESCENT; ADULT; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; BODY WEIGHT; BONE DENSITY; CLINICAL ARTICLE; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; ESTRADIOL BLOOD LEVEL; EXERCISE; FEMALE; FITNESS; FOLLITROPIN BLOOD LEVEL; HUMAN; HYPERGONADOTROPIC HYPOGONADISM; HYPOESTROGENISM; HYPOGONADISM; LUTEINIZING HORMONE BLOOD LEVEL; MENSTRUAL IRREGULARITY; OLIGOMENORRHEA; OVARY INSUFFICIENCY; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; TESTOSTERONE BLOOD LEVEL;

ADOLESCENT; BODY COMPOSITION; BONE DENSITY; ESTROGENS; FEMALE; HUMANS; HYPOGONADISM; OLIGOMENORRHEA; PHYSICAL FITNESS; TESTOSTERONE;

EID: 69349105739     PISSN: 10833188     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpag.2008.12.010     Document Type: Article

References (25)

1. Ramos R.H., and Warren M.P. The interrelationships of body fat, exercise, and hormonal status and their impact on reproduction and bone health. Sem Perinatol 19 (1995) 163
2. Goodman L.R., and Warren M.P. The female athlete and menstrual function. Curr Opin Obstet Gynecol 17 (2005) 466
3. Warren M.P., and Perlroth N.E. The effects of intense exercise on the female reproductive system. J Endocrinol 170 (2001) 3
4. Azziz R., Sanchez L.A., Knochenhauer E.S., et al. Androgen excess in women: Experience with over 1000 consecutive patients. J Clin Endocrinol Metabol 89 (2004) 453
5. Rickenlund A., Carlstrom K., Ekblom B., et al. Effects of oral contraceptives on body composition and physical performance in female athletes. J Clin Endocrinol Metabol 89 (2004) 4364
6. van Hooff M.H., Voorhorst F.J., Kaptein M.B., et al. Insulin, androgen, and gonadotropin concentrations, body mass index, and waist to hip ratio in the first years after menarche in girls with regular menstrual cycles, irregular menstrual cycles, or oligomenorrhea. J Clin Endocrinol Metabol 85 (2000) 1394
7. van Hooff M.H., Voorhorst F.J., Kaptein M.B., et al. Predictive value of menstrual cycle pattern, body mass index, hormone levels and polycystic ovaries at age 15 years for oligo-amenorrhoea at age 18 years. Hum Reprod (Oxford) 19 (2004) 383
8. Apter D., Butzow T., Laughlin G.A., et al. Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism. J Clin Endocrinol Metabol 80 (1995) 2966
9. Laughlin G.A., and Yen S.S. Nutritional and endocrine-metabolic aberrations in amenorrheic athletes. J Clin Endocrinol Metabol 81 (1996) 4301
10. Chen E.C., and Brzyski R.G. Exercise and reproductive dysfunction. Fertil Steril 71 (1999) 1
11. Castelo-Branco C., Vicente J.J., Pons F., et al. Bone mineral density in young, hypothalamic oligoamenorrheic women treated with oral contraceptives. J Reprod Med 46 (2001) 875
12. Siegberg R., Nilsson C.G., Stenman U.H., et al. The effect of oral contraceptives on hormone profiles of oligomenorrheic adolescent cycles. Contraception 35 (1987) 29
13. Azziz R., Carmina E., and Sawaya M.E. Idiopathic hirsutism. Endocr Rev 21 (2000) 347
14. Kasa-Vubu J.Z., Rosenthal A., Murdock E.G., et al. Impact of fatness, fitness, and ethnicity on the relationship of nocturnal ghrelin to 24-hour luteinizing hormone concentrations in adolescent girls. J Clin Endocrinol Metabol 92 (2007) 3246
15. Ahmad F., Kavey R.E., Kveselis D.A., et al. Responses of non-obese white children to treadmill exercise. J Pediatr 139 (2001) 284
16. Kasa-Vubu J.Z., Lee C.C., Rosenthal A., et al. Cardiovascular fitness and exercise as determinants of insulin resistance in postpubertal adolescent females. J Clin Endocrinol Metabol 90 (2005) 849
17. Committee of Physical Activity Guidelines for Americans. In: Office of Disease Prevention & Health Promotion. Edited by US Department of Health and Human Services, 2008
18. Arroyo A., Laughlin G.A., Morales A.J., et al. Inappropriate gonadotropin secretion in polycystic ovary syndrome: influence of adiposity. J Clin Edocrinol Metabol 82 (1997) 3728
19. Cupisti S., Dittrich R., Binder H., et al. Evaluation of biochemical hyperandrogenemia and body mass index in women presenting with amenorrhea. Exp Clin Endocrinol Diabetes 115 (2007) 298
20. Hillier S.G., and Tetsuka M. Role of androgens in follicle maturation and atresia. Baillieres Clin Obstet Gynaecol 11 (1997) 249
21. Hsu M.I., Liou T.H., Liang S.J., et al. Inappropriate gonadotropin secretion in polycystic ovary syndrome. Fertil Steril (2009)
22. Rickenlund A., Carlstrom K., Ekblom B., et al. Hyperandrogenicity is an alternative mechanism underlying oligomenorrhea or amenorrhea in female athletes and may improve physical performance. Fertil Steril 79 (2003) 947
23. Coviello A.D., Legro R.S., and Dunaif A. Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance. J Clin Endocrinol Metabol 91 (2006) 492
24. Miller K.K., Lawson E.A., Mathur V., et al. Androgens in women with anorexia nervosa and normal-weight women with hypothalamic amenorrhea. J Clin Endocrinol Metabol 92 (2007) 1334
25. Constantini N.W., and Warren M.P. Menstrual dysfunction in swimmers: A distinct entity. J Clin Endocrinol Metabol 80 (1995) 2740