Polymorphisms in thrombophilia and renin-angiotensin system pathways, preterm delivery, and evidence of placental hemorrhage

American Journal of Obstetrics and Gynecology

Volumn 201, Issue 3, 2009, Pages 317.e1-317.e9

  Gargano, Julia Warner ^a   Holzman, Claudia B ^a   Senagore, Patricia K ^c   Reuss, M Lynne ^d   Pathak, Dorothy R ^a   Friderici, Karen H ^a,b   Jernigan, Katherine ^b   Fisher, Rachel ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Southwest Women's Sonography ^*  (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d Southwest Women's Sonography   (United States)

Author keywords

gene polymorphism; placental abruption; placental pathologic finding; preterm delivery; thrombophilia

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALPHA FETOPROTEIN; ANGIOTENSIN; ANGIOTENSINOGEN; BIOLOGICAL MARKER; BLOOD CLOTTING FACTOR 5 LEIDEN; DNA; RENIN; VITAMIN;

ADULT; ANGIOTENSINOGEN GENE; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DNA POLYMORPHISM; FACTOR V LEIDEN GENE; FEMALE; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; PATHOPHYSIOLOGY; PREMATURITY; PRIORITY JOURNAL; RACE DIFFERENCE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SECOND TRIMESTER PREGNANCY; SOLUTIO PLACENTAE; THROMBOPHILIA;

EID: 69349104050     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2009.05.060     Document Type: Article

References (40)

1. Green N.S., Damus K., Simpson J.L., et al. Research agenda for preterm birth: recommendations from the March of Dimes. Am J Obstet Gynecol 193 (2005) 626-635
2. Ananth C.V., Berkowitz G.S., Savitz D.A., and Lapinski R.H. Placental abruption and adverse perinatal outcomes. JAMA 282 (1999) 1646-1651
3. Salafia C.M., Lopez-Zeno J.A., Sherer D.M., Whittington S.S., Minior V.K., and Vintzileos A.M. Histologic evidence of old intrauterine bleeding is more frequent in prematurity. Am J Obstet Gynecol 173 (1995) 1065-1070
4. Ananth C.V., Peltier M.R., Chavez M.R., Kirby R.S., Getahun D., and Vintzileos A.M. Recurrence of ischemic placental disease. Obstet Gynecol 110 (2007) 128-133
5. Misra D.P., and Ananth C.V. Risk factor profiles of placental abruption in first and second pregnancies: heterogeneous etiologies. J Clin Epidemiol 52 (1999) 453-461
6. Zdoukopoulos N., and Zintzaras E. Genetic risk factors for placental abruption: a HuGE review and meta-analysis. Epidemiology 19 (2008) 309-323
7. Engel S.M., Olshan A.F., Siega-Riz A.M., Savitz D.A., and Chanock S.J. Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth. Am J Obstet Gynecol 195 (2006) 1231.e1-1231.e11
8. Kocher O., Cirovic C., Malynn E., et al. Obstetric complications in patients with hereditary thrombophilia identified using the LCx microparticle enzyme immunoassay: a controlled study of 5,000 patients. Am J Clin Pathol 127 (2007) 68-75
9. Resch B., Gallistl S., Kutschera J., Mannhalter C., Muntean W., and Mueller W.D. Thrombophilic polymorphisms-factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations-and preterm birth. Wien Klin Wochenschr 116 (2004) 622-626
10. Stonek F., Hafner E., Philipp K., Hefler L.A., Bentz E.K., and Tempfer C.B. Methylenetetrahydrofolate reductase C677T polymorphism and pregnancy complications. Obstet Gynecol 110 (2007) 363-368
11. Valdez L.L., Quintero A., Garcia E., et al. Thrombophilic polymorphisms in preterm delivery. Blood Cells Mol Dis 33 (2004) 51-56
12. Valdez-Velazquez L.L., Quintero-Ramos A., Perez S.A., et al. Genetic polymorphisms of the renin-angiotensin system in preterm delivery and premature rupture of membranes. J Renin Angiotensin Aldosterone Syst 8 (2007) 160-168
13. Ariel I., Anteby E., Hamani Y., and Redline R.W. Placental pathology in fetal thrombophilia. Hum Pathol 35 (2004) 729-733
14. Many A., Schreiber L., Rosner S., Lessing J.B., Eldor A., and Kupferminc M.J. Pathologic features of the placenta in women with severe pregnancy complications and thrombophilia. Obstet Gynecol 98 (2001) 1041-1044
15. Mousa H.A., and Alfirevic Z. Do placental lesions reflect thrombophilia state in women with adverse pregnancy outcome?. Hum Reprod 15 (2000) 1830-1833
16. Holzman C., Lin X., Senagore P., and Chung H. Histologic chorioamnionitis and preterm delivery. Am J Epidemiol 166 (2007) 786-794
17. Kelly R., Holzman C., Senagore P., et al. Placental vascular findings and pathways to preterm delivery. Am J Epidemiol 170 (2009) 148-158
18. Molina-Molina M., Xaubet A., Li X., et al. Angiotensinogen gene G-6A polymorphism influences idiopathic pulmonary fibrosis disease progression. Eur Respir J 32 (2008) 1004-1008
19. Ridker P.M., Hennekens C.H., Lindpaintner K., Stampfer M.J., Eisenberg P.R., and Miletich J.P. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 332 (1995) 912-917
20. Brenner B. Haemostatic changes in pregnancy. Thromb Res 114 (2004) 409-414
21. Krikun G., Huang S.T., Schatz F., Salafia C., Stocco C., and Lockwood C.J. Thrombin activation of endometrial endothelial cells: a possible role in intrauterine growth restriction. Thromb Haemost 97 (2007) 245-253
22. Lockwood C.J., Toti P., Arcuri F., et al. Mechanisms of abruption-induced premature rupture of the fetal membranes: thrombin-enhanced interleukin-8 expression in term decidua. Am J Pathol 167 (2005) 1443-1449
23. Jeunemaitre X., Inoue I., Williams C., et al. Haplotypes of angiotensinogen in essential hypertension. Am J Hum Genet 60 (1997) 1448-1460
24. Hillermann R., Carelse K., and Gebhardt G.S. The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia. J Hum Genet 50 (2005) 415-419
25. Zhang X.Q., Craven C., Nelson L., Varner M.W., and Ward K.J. Placental abruption is more frequent in women with the angiotensinogen Thr235 mutation. Placenta 28 (2007) 616-619
26. Medica I., Kastrin A., and Peterlin B. Genetic polymorphisms in vasoactive genes and preeclampsia: a meta-analysis. Eur J Obstet Gynecol Reprod Biol 131 (2007) 115-126
27. Sethi A.A., Nordestgaard B.G., and Tybjaerg-Hansen A. Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis. Arterioscler Thromb Vasc Biol 23 (2003) 1269-1275
28. Ananth C.V., Savitz D.A., and Williams M.A. Placental abruption and its association with hypertension and prolonged rupture of membranes: a methodologic review and meta-analysis. Obstet Gynecol 88 (1996) 309-318
29. Hogberg V., Rasmussen S., and Irgens L.M. The effect of smoking and hypertensive disorders on abruptio placentae in Norway 1999-2002. Acta Obstet Gynecol Scand 86 (2007) 304-309
30. Zetterstrom K., Lindeberg S.N., Haglund B., and Hanson U. Maternal complications in women with chronic hypertension: a population-based cohort study. Acta Obstet Gynecol Scand 84 (2005) 419-424
31. Williams M.A., Mittendorf R., and Monson R.R. Chronic hypertension, cigarette smoking, and abruptio placentae. Epidemiology 2 (1991) 450-453
32. Morgan T., Craven C., Nelson L., Lalouel J.M., and Ward K. Angiotensinogen T235 expression is elevated in decidual spiral arteries. J Clin Invest 100 (1997) 1406-1415
33. Ananth C.V., Peltier M.R., De Marco C., et al. Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption. Am J Obstet Gynecol 197 (2007) 385.e1-385.e7
34. Jaaskelainen E., Keski-Nisula L., Toivonen S., et al. MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women. Hypertens Pregnancy 25 (2006) 73-80
35. Karakantza M., Androutsopoulos G., Mougiou A., Sakellaropoulos G., Kourounis G., and Decavalas G. Inheritance and perinatal consequences of inherited thrombophilia in Greece. Int J Gynaecol Obstet 100 (2008) 124-129
36. Parle-McDermott A., Mills J.L., Kirke P.N., et al. MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae. Am J Med Genet A 132 (2005) 365-368
37. Prochazka M., Lubusky M., Slavik L., et al. Frequency of selected thrombophilias in women with placental abruption. Aust N Z J Obstet Gynaecol 47 (2007) 297-301
38. Nurk E., Tell G.S., Refsum H., Ueland P.M., and Vollset S.E. Associations between maternal methylenetetrahydrofolate reductase polymorphisms and adverse outcomes of pregnancy: the Hordaland Homocysteine study. Am J Med 117 (2004) 26-31
39. Ioannidis J.P. Why most discovered true associations are inflated. Epidemiology 19 (2008) 640-648
40. Rothman K.J. No adjustments are needed for multiple comparisons. Epidemiology 1 (1990) 43-46