A case-control association study between the CYP3A4 and CYP3A5 genes and schizophrenia in the Chinese Han population

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 33, Issue 7, 2009, Pages 1200-1204

  Du, Jing ^a,b   Xu, Yifeng ^c   Duan, Shiwei ^a,d   Zhang, Aiping ^a,d   Xuan, Jiekun ^a,d   Wang, Lei ^a,d   Yu, Lan ^a,d   Wang, Hongsheng ^a,d   Li, Xingwang ^a,d   Feng, Guoyin ^c   He, Lin ^a,d,e   Xing, Qinghe ^a,d  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF PLANNED PARENTHOOD RESEARCH   (China)

^c SHANGHAI MENTAL HEALTH CENTER   (China)

^d FUDAN UNIVERSITY   (China)

^e Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

CYP3A4; CYP3A5; Schizophrenia

Indexed keywords

CYTOCHROME P450 3A4; CYTOCHROME P450 3A5;

ADULT; ARTICLE; BEHAVIOR GENETICS; CHINESE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION BASED CASE CONTROL STUDY; SCHIZOPHRENIA;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CYTOCHROME P-450 CYP3A; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA;

EID: 69349100319     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2009.06.023     Document Type: Article

References (46)

1. Ahmadi K.R., Weale M.E., Xue Z.Y., Soranzo N., Yarnall D.P., Briley J.D., et al. A single-nucleotide polymorphism tagging set for human drug metabolism and transport. Nat Genet 37 (2005) 84-89
2. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
3. Chen W., Duan S., Zhou J., Sun Y., Zheng Y., Gu N., et al. A case-control study provides evidence of association for a functional polymorphism - 197C/G in XBP1 to schizophrenia and suggests a sex-dependent effect. Biochem Biophys Res Commun 319 (2004) 866-870
4. Chen W., Gu N., Duan S., Sun Y., Zheng Y., Li C., et al. No association between the genetic polymorphisms within RTN4 and schizophrenia in the Chinese population. Neurosci Lett 365 (2004) 23-27
5. Chen W.Y., Shi Y.Y., Zheng Y.L., Zhao X.Z., Zhang G.J., Chen S.Q., et al. Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8. Hum Mol Genet 13 (2004) 2991-2995
6. Chen Q., He G., Chen Q., Wu S., Xu Y., Feng G., et al. A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population. Schizophr Res 73 (2005) 21-26
7. Collier D.A., and Li T. The genetics of schizophrenia: glutamate not dopamine?. Eur J Pharmacol 480 (2003) 177-184
8. Daly A.K. Significance of the minor cytochrome P450 3A isoforms. Clin Pharmacokinet 45 (2006) 13-31
9. Dorado P., Penas-Lledo E.M., and Llerena A. CYP2D6 polymorphism: implications for antipsychotic drug response, schizophrenia and personality traits. Pharmacogenomics 8 (2007) 1597-1608
10. Du J., Xing Q., Xu L., Xu M., Shu A., Shi Y., et al. Systematic screening for polymorphisms in the CYP3A4 gene in the Chinese population. Pharmacogenomics 7 (2006) 831-841
11. Duan S., Xu Y., Chen W., Liu Z., Guo T., Gao J., et al. No association between the promoter variants of tumor necrosis factor alpha (TNF-alpha) and schizophrenia in Chinese Han population. Neurosci Lett 366 (2004) 139-143
12. Duan S., Yin H., Chen W., Xing Q., chen Q., Guo T., et al. No association between the serotonin 1B receptor gene and schizophrenia in a case-control and family-based association study. Neurosci Lett 376 (2005) 93-97
13. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25 (2003) 115-121
14. Dutheil F., Beaune P., and Loriot M.A. Xenobiotic metabolizing enzymes in the central nervous system: contribution of cytochrome P450 enzymes in normal and pathological human brain. Biochimie 90 (2008) 426-436
15. Ekelund J., Lichtermann D., Hovatta I., Ellonen P., Suvisaari J., Terwilliger J.D., et al. Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22. Hum Mol Genet 9 (2000) 1049-1057
16. Fan J.B., Tang J.X., Gu N.F., Feng G.Y., Zou F.G., Xing Y.L., et al. A family-based and case-control association study of the NOTCH4 gene and schizophrenia. Mol Psychiatry 7 (2002) 100-103
17. Fan R., and Knapp M. Genome association studies of complex diseases by case-control designs. Am J Hum Genet 72 (2003) 850-868
18. Fukushima-Uesaka H., Saito Y., Watanabe H., Shiseki K., Saeki M., Nakamura T., et al. Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population. Human Mutat 23 (2004) 100
19. Guo S., Tang W., Shi Y., Huang K., Xi Z., Xu Y., et al. RGS4 polymorphisms and risk of schizophrenia: an association study in Han Chinese plus meta-analysis. Neurosci Lett 406 (2006) 122-127
20. He P., Court M.H., Greenblatt D.J., and Von Moltke L.L. Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo. Clin Pharmacol Ther 77 (2005) 373-387
21. Hu J.X., Yu L., Shi Y.Y., Zhao X.Z., Meng J.W., He G., et al. An association study between PPP1R1B gene and schizophrenia in the Chinese population. Prog Neuropsychopharmacol Biol Psychiatry 31 (2007) 1303-1306
22. Jia Y., Yu X., Zhang B., Yuan Y., Xu Q., Shen Y., et al. No association between polymorphisms in three genes of cytochrome p450 family and paranoid schizophrenia in northern Chinese Han population. Eur Psychiatry 19 (2004) 374-376
23. KEGG is a database of biological systems, consisting of genetic building blocks of genes and proteins (KEGG GENES), chemical building blocks of both endogenous and exogenous substances (KEGG LIGAND), molecular wiring diagrams of interaction and reaction networks (KEGG PATHWAY), and hierarchies and relationships of various biological objects (KEGG BRITE). KEGG provides a reference knowledge base for linking genomes to biological systems and also to environments by the processes of PATHWAY mapping and BRITE mapping. http://www.genome.jp/en/about_kegg.html. 2007. Ref Type: Generic.
24. Knable M.B., and Weinberger D.R. Dopamine, the prefrontal cortex and schizophrenia. J Psychopharmacol 11 (1997) 123-131
25. Kuehl P., Zhang J., Lin Y., Lamba J., Assem M., Schuetz J., et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 27 (2001) 383-391
26. Lieberman J.A., Mailman R.B., Duncan G., Sikich L., Chakos M., Nichols D.E., et al. Serotonergic basis of antipsychotic drug effects in schizophrenia. Biol Psychiatry 44 (1998) 1099-1117
27. Llerena A., Dorado P., Penas-Lledo E.M., Caceres M.C., and De la R.A. Low frequency of CYP2D6 poor metabolizers among schizophrenia patients. Pharmacogenomics J 7 (2007) 408-410
28. Lucki I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry 44 (1998) 151-162
29. Ma G., Shi Y., Tang W., He Z., Huang K., Li Z., et al. An association study between the genetic polymorphisms within TBX1 and schizophrenia in the Chinese population. Neurosci Lett 425 (2007) 146-150
30. Meng J., Shi Y., Zhao X., Zhou J., Zheng Y., Tang R., et al. No significant association between the genetic polymorphisms in the GSK-3beta gene and schizophrenia in the Chinese population. J Psychiatr Res (2007)
31. Miyamoto S., LaMantia A.S., Duncan G.E., Sullivan P., Gilmore J.H., and Lieberman J.A. Recent advances in the neurobiology of schizophrenia. Mol Interv 3 (2003) 27-39
32. Shi Y.Y., and He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15 (2005) 97-98
33. Stefansson H., Rujescu D., Cichon S., Pietilainen O.P., Ingason A., Steinberg S., et al. Large recurrent microdeletions associated with schizophrenia. Nature 455 (2008) 232-236
34. Tao R., Li C., Zheng Y., Qin W., Zhang J., Li X., et al. Positive association between SIAT8B and schizophrenia in the Chinese Han population. Schizophr Res 90 (2007) 108-114
35. Tiwari A.K., Deshpande S.N., Rao A.R., Bhatia T., Lerer B., Nimgaonkar V.L., et al. Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms. Schizophr Res 75 (2005) 21-26
36. Veenstra-VanderWeele J., Anderson G.M., and Cook Jr. E.H. Pharmacogenetics and the serotonin system: initial studies and future directions. Eur J Pharmacol 410 (2000) 165-181
37. Wang X., He G., Gu N., Yang J., Tang J., Chen Q., et al. Association of G72/G30 with schizophrenia in the Chinese population. Biochem Biophys Res Commun 319 (2004) 1281-1286
38. Xing Q.H., Wu S.N., Lin Z.G., Li H.F., Yang J.D., Feng G.Y., et al. Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene in schizophrenia. Schizophr Res 65 (2003) 9-14
39. Xu M.Q., St Clair D., Ott J., Feng G.Y., and He L. Brain-derived neurotrophic factor gene C-270T and Val66Met functional polymorphisms and risk of schizophrenia: a moderate-scale population-based study and meta-analysis. Schizophr Res 91 (2007) 6-13
40. Yang M.S., Yu L., Guo T.W., Zhu S.M., Liu H.J., Shi Y.Y., et al. Evidence for association between single nucleotide polymorphisms in T complex protein 1 gene and schizophrenia in the Chinese Han population. J Med Genet 41 (2004) e63
41. Yu L., Yang M.S., Zhao J., Shi Y.Y., Zhao X.Z., Yang J.D., et al. An association between polymorphisms of the interleukin-10 gene promoter and schizophrenia in the Chinese population. Schizophr Res 71 (2004) 179-183
42. Zeigler-Johnson C., Friebel T., Walker A.H., Wang Y., Spangler E., Panossian S., et al. CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer. Cancer Res 64 (2004) 8461-8467
43. Zhang B., Tan Z., Zhang C., Shi Y., Lin Z., Gu N., et al. Polymorphisms of chromogranin B gene associated with schizophrenia in Chinese Han population. Neurosci Lett 323 (2002) 229-233
44. Zhang C.S., Tan Z., Lu L., Wu S.N., He Y., Gu N.F., et al. Polymorphism of prodynorphin promoter is associated with schizophrenia in Chinese population. Acta Pharmacol Sin 25 (2004) 1022-1026
45. Zhang X., Li D., Duan S., Duan Y., Chen Q., Li X., et al. Analysis of the association between apolipoprotein D and schizophrenia. Neuropsychobiology 54 (2006) 40-44
46. Zheng Y., Li H., Qin W., Chen W., Duan Y., Xiao Y., et al. Association of the carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase gene with schizophrenia in the Chinese Han population. Biochem Biophys Res Commun 328 (2005) 809-815