Interleukin-21 regulates expression of the immediate-early lytic cycle genes and proteins in Epstein-Barr Virus infected B cells

Virus Research

Volumn 144, Issue 1-2, 2009, Pages 339-343

  Konforte, Danijela ^a   Paige, Christopher J ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

EBV; Gene expression; IL 21; Lytic cycle

Indexed keywords

IMMEDIATE EARLY PROTEIN; IMMEDIATE EARLY PROTEIN BZLF1; IMMEDIATE EARLY PROTEIN RTA; INTERLEUKIN 21; JANUS KINASE; PROTEIN EA D; STAT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BURKITT LYMPHOMA; CELL CULTURE; CONTROLLED STUDY; CYTOLYSIS; EPSTEIN BARR VIRUS; GENE EXPRESSION REGULATION; LYMPHOBLASTOID CELL LINE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VIRUS CELL INTERACTION;

B-LYMPHOCYTES; CELL LINE; GENE EXPRESSION REGULATION, VIRAL; GENES, IMMEDIATE-EARLY; HERPESVIRUS 4, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERLEUKINS; TRANS-ACTIVATORS;

HUMAN HERPESVIRUS 4;

EID: 69249221314     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virusres.2009.05.003     Document Type: Article

References (35)

1. Altmeyer A., Simmons R.C., Krajewski S., Reed J.C., Bornkamm G.W., and Chen-Kiang S. Reversal of EBV immortalization precedes apoptosis in IL-6-induced human B cell terminal differentiation. Immunity 7 5 (1997) 667-677
2. Anisimova E., Prachova K., Roubal J., and Vonka V. Effects of n-butyrate and phorbol ester (TPA) on induction of Epstein-Barr virus antigens and cell differentiation. Arch. Virol. 81 3-4 (1984) 223-237
3. Bhende P.M., Dickerson S.J., Sun X., Feng W.H., and Kenney S.C. X-box-binding protein 1 activates lytic Epstein-Barr virus gene expression in combination with protein kinase D. J. Virol. 81 14 (2007) 7363-7370
4. Brewer J.W., and Hendershot L.M. Building an antibody factory: a job for the unfolded protein response. Nat. Immunol. 6 1 (2005) 23-29
5. Calfon M., Zeng H., Urano F., Till J.H., Hubbard S.R., Harding H.P., Clark S.G., and Ron D. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415 6867 (2002) 92-96
6. Chasserot-Golaz S., Schuster C., Dietrich J.B., Beck G., and Lawrence D.A. Antagonistic action of RU38486 on the activity of transforming growth factor-beta in fibroblasts and lymphoma cells. J. Steroid Biochem. 30 1-6 (1988) 381-385
7. Ettinger R., Kuchen S., and Lipsky P.E. The role of IL-21 in regulating B-cell function in health and disease. Immunol. Rev. 223 (2008) 60-86
8. Ettinger R., Sims G.P., Fairhurst A.M., Robbins R., da Silva Y.S., Spolski R., Leonard W.J., and Lipsky P.E. IL-21 induces differentiation of human naive and memory B Cells into antibody-secreting plasma cells. J. Immunol. 175 12 (2005) 7867-7879
9. Faggioni A., Zompetta C., Grimaldi S., Barile G., Frati L., and Lazdins J. Calcium modulation activates Epstein-Barr virus genome in latently infected cells. Science 232 4757 (1986) 1554-1556
10. Fahmi H., Cochet C., Hmama Z., Opolon P., and Joab I. Transforming growth factor beta 1 stimulates expression of the Epstein-Barr virus BZLF1 immediate-early gene product ZEBRA by an indirect mechanism which requires the MAPK kinase pathway. J. Virol. 74 13 (2000) 5810-5818
11. Flamand L., Stefanescu I., Ablashi D.V., and Menezes J. Activation of the Epstein-Barr virus replicative cycle by human herpesvirus 6. J. Virol. 67 11 (1993) 6768-6777
12. Fu D.X., Tanhehco Y.C., Chen J., Foss C.A., Fox J.J., Lemas V., Chong J.M., Ambinder R.F., and Pomper M.G. Virus-associated tumor imaging by induction of viral gene expression. Clin. Cancer Res. 13 5 (2007) 1453-1458
13. Good K.L., Bryant V.L., and Tangye S.G. Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J. Immunol. 177 8 (2006) 5236-5247
14. Holley-Guthrie E.A., Seaman W.T., Bhende P., Merchant J.L., and Kenney S.C. The Epstein-Barr virus protein BMRF1 activates gastrin transcription. J. Virol. 79 2 (2005) 745-755
15. Hong G.K., Gulley M.L., Feng W.H., Delecluse H.J., Holley-Guthrie E., and Kenney S.C. Epstein-Barr virus lytic infection contributes to lymphoproliferative disease in a SCID mouse model. J. Virol. 79 22 (2005) 13993-14003
16. Iwakoshi N.N., Lee A.H., Vallabhajosyula P., Otipoby K.L., Rajewsky K., and Glimcher L.H. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat. Immunol. 4 4 (2003) 321-329
17. Johnson K., Shapiro-Shelef M., Tunyaplin C., and Calame K. Regulatory events in early and late B-cell differentiation. Mol. Immunol. 42 7 (2005) 749-761
18. Kiehl A., and Dorsky D.I. Bipartite DNA-binding region of the Epstein-Barr virus BMRF1 product essential for DNA polymerase accessory function. J. Virol. 69 3 (1995) 1669-1677
19. Klein B., Tarte K., Jourdan M., Mathouk K., Moreaux J., Jourdan E., Legouffe E., De Vos J., and Rossi J.F. Survival and proliferation factors of normal and malignant plasma cells. Int. J. Hematol. 78 2 (2003) 106-113
20. Konforte D., and Paige C.J. Identification of cellular intermediates and molecular pathways induced by IL-21 in human B cells. J. Immunol. 177 12 (2006) 8381-8392
21. Konforte D., Simard N., and Paige C.J. Interleukin-21 regulates expression of key Epstein-Barr virus oncoproteins, EBNA2 and LMP1, in infected human B cells. Virology 374 1 (2008) 100-113
22. Laichalk L.L., and Thorley-Lawson D.A. Terminal differentiation into plasma cells initiates the replicative cycle of Epstein-Barr virus in vivo. J. Virol. 79 2 (2005) 1296-1307
23. Leonard W.J., and Spolski R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat. Rev. Immunol. 5 9 (2005) 688-698
24. McIntosh R.V., Cohen B.B., Steel C.M., Read H., Moxley M., and Evans H.J. Evidence for involvement of the immunoglobulin heavy-chain gene locus in the 8:14 translocation of human B lymphomas. Int. J. Cancer 31 3 (1983) 275-279
25. Niedobitek G., Agathanggelou A., Steven N., and Young L.S. Epstein-Barr virus (EBV) in infectious mononucleosis: detection of the virus in tonsillar B lymphocytes but not in desquamated oropharyngeal epithelial cells. Mol. Pathol. 53 1 (2000) 37-42
26. Ozaki K., Spolski R., Feng C.G., Qi C.F., Cheng J., Sher A., Morse III H.C., Liu C., Schwartzberg P.L., and Leonard W.J. A critical role for IL-21 in regulating immunoglobulin production. Science 298 5598 (2002) 1630-1634
27. Shaffer A.L., Shapiro-Shelef M., Iwakoshi N.N., Lee A.H., Qian S.B., Zhao H., Yu X., Yang L., Tan B.K., Rosenwald A., Hurt E.M., Petroulakis E., Sonenberg N., Yewdell J.W., Calame K., Glimcher L.H., and Staudt L.M. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 21 1 (2004) 81-93
28. Sun C.C., and Thorley-Lawson D.A. Plasma cell-specific transcription factor XBP-1 s binds to and transactivates the Epstein-Barr virus BZLF1 promoter. J. Virol. 81 24 (2007) 13566-13577
29. Thorley-Lawson D.A. Epstein-Barr virus: exploiting the immune system. Nat. Rev. Immunol. 1 1 (2001) 75-82
30. Thorley-Lawson D.A. EBV the prototypical human tumor virus--just how bad is it?. J. Allergy Clin. Immunol. 116 2 (2005) 251-261 (quiz 262)
31. Tovey M.G., Lenoir G., and Begon-Lours J. Activation of latent Epstein-Barr virus by antibody to human IgM. Nature 276 5685 (1978) 270-272
32. Yoshida H., Matsui T., Yamamoto A., Okada T., and Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107 7 (2001) 881-891
33. Young L.S., and Rickinson A.B. Epstein-Barr virus: 40 years on. Nat. Rev. Cancer 4 10 (2004) 757-768
34. Yuan J., Cahir-McFarland E., Zhao B., and Kieff E. Virus and cell RNAs expressed during Epstein-Barr virus replication. J. Virol. 80 5 (2006) 2548-2565
35. zur Hausen H., O'Neill F.J., Freese U.K., and Hecker E. Persisting oncogenic herpesvirus induced by the tumour promotor TPA. Nature 272 5651 (1978) 373-375