Arginine methylation of the ICP27 RGG box regulates the functional interactions of ICP27 with SRPK1 and Aly/REF during herpes simplex virus 1 infection

Journal of Virology

Volumn 83, Issue 17, 2009, Pages 8970-8975

  Souki, Stuart K ^a   Sandri Goldin, Rozanne M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIALDEHYDE; ARGININE; ARGINYLGLYCYLGLYCINE; GLYCINE; INFECTED CELL PROTEIN 27; LYSINE; PROTEIN ALY; PROTEIN SERINE KINASE 1; TRIPEPTIDE; UNCLASSIFIED DRUG; VIRUS PROTEIN; ICP27 PROTEIN, HUMAN HERPESVIRUS 1; IMMEDIATE EARLY PROTEIN; MUTANT PROTEIN; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; RNA BINDING PROTEIN; SRPK1 PROTEIN, HUMAN; THOC4 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN METHYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; VIRUS MUTANT; CONFOCAL MICROSCOPY; GENETICS; HELA CELL; METABOLISM; METHODOLOGY; METHYLATION; PHYSIOLOGY; PROTEIN ANALYSIS; SITE DIRECTED MUTAGENESIS; VIRUS REPLICATION;

HUMAN HERPESVIRUS 1;

AMINO ACID SUBSTITUTION; ARGININE; HELA CELLS; HERPESVIRUS 1, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; IMMUNOPRECIPITATION; METHYLATION; MICROSCOPY, CONFOCAL; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN-SERINE-THREONINE KINASES; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS; VIRUS REPLICATION;

EID: 69249214146     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00801-09     Document Type: Article

References (18)

1. Bedford, M. T., and S. G. Clarke. 2009. Protein arginine methylation in mammals: who, what and why. Mol. Cell 33:1-13.
2. Bedford, M. T., and S. Richard. 2005. Arginine methylation: an emerging regulator of protein function. Mol. Cell 18:263-272. (Pubitemid 41350532)
3. Bryant, H. E., S. Wadd, A. I. Lamond, S. J. Silverstein, and J. B. Clements. 2001. Herpes simplex virus IE63 (ICP27) protein interacts with spliceosome-associated protein 145 and inhibits splicing prior to the first catalytic step. J. Virol. 75:4376-4385.
4. Chen, I. B., L. Li, L. Silva, and R. M. Sandri-Goldin. 2005. ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export. J. Virol. 79:3949-3961.
5. Chen, I. B., K. S. Sciabica, and R. M. Sandri-Goldin. 2002. ICP27 interacts with the export factor Aly/REF to direct herpes simplex virus 1 intronless RNAs to the TAP export pathway. J. Virol. 76:12877-12889.
6. Johnson, L. A., L. Li, and R. M. Sandri-Goldin. 2009. The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable. J. Virol. 83:6335-6346.
7. Koffa, M. D., J. B. Clements, E. Izaurralde, S. Wadd, S. A. Wilson, I. W. Mattaj, and S. Kuersten. 2001. Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. EMBO J. 20:5769-5778.
8. Lukong, K. E., and S. Richard. 2004. Arginine methylation signals mRNA export. Nat. Struct. Mol. Biol. 11:914-915.
9. Masuda, S., R. Das, H. Cheng, E. Hurt, N. Dorman, and R. Reed. 2005. Recruitment of the human TREX complex to mRNA during splicing. Genes Dev. 19:1512-1517.
10. Mears, W. E., and S. A. Rice. 1996. The RGG box motif of the herpes simplex virus ICP27 protein mediates an RNA-binding activity and determines in vivo methylation. J. Virol. 70:7445-7453.
11. Pahlich, S., R. Zakaryan, and H. Gehring. 2006. Protein arginine methylation: cellular functions and methods of analysis. Biochim. Biophys. Acta 1764:1890-1903.
12. Sandri-Goldin, R. M. 1998. ICP27 mediates herpes simplex virus RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif. Genes Dev. 12:868-879.
13. Sciabica, K. S., Q. J. Dai, and R. M. Sandri-Goldin. 2003. ICP27 interacts with SRPK1 to mediate HSV-1 inhibition of pre-mRNA splicing by altering SR protein phosphorylation. EMBO J. 22:1608-1619.
14. Smith, I. L., M. A. Hardwicke, and R. M. Sandri-Goldin. 1992. Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression. Virology 186:74-86.
15. Soliman, T. M., R. M. Sandri-Goldin, and S. J. Silverstein. 1997. Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins. J. Virol. 71:9188-9197.
16. Souki, S. K., P. D. Gerson, and R. M. Sandri-Goldin. 2009. Arginine methylation of the ICP27 RGG box regulates ICP27 export and is required for efficient herpes simplex virus 1 replication. J. Virol. 83:5309-5320.
17. Stutz, F., A. Bachi, T. Doerks, I. C. Braun, B. Seraphin, M. Wilm, P. Bork, and E. Izaurralde. 2000. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA 6:638-650. (Pubitemid 30212241)
18. Zhou, Z., M. J. Luo, K. Straesser, J. Katahira, E. Hurt, and R. Reed. 2000. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature 407:401-405.