Arabidopsis thaliana encodes a bacterial-type heterodimeric isopropylmalate isomerase involved in both Leu biosynthesis and the Met chain elongation pathway of glucosinolate formation

Plant Molecular Biology

Volumn 71, Issue 3, 2009, Pages 227-239

  Knill, Tanja ^a   Reichelt, Michael ^b   Paetz, Christian ^b   Gershenzon, Jonathan ^b   Binder, Stefan ^a  

^a UNIVERSITY OF ULM   (Germany)

^b MAX PLANCK INSTITUTE FOR CHEMICAL ECOLOGY   (Germany)

Author keywords

Glucosinolate biosynthesis; Isopropylmalate isomerase; Leucine metabolism; Methionine chain elongation pathway

Indexed keywords

2 ISOPROPYLMALIC ACID; 2-ISOPROPYLMALIC ACID; AMINO ACID; ARABIDOPSIS PROTEIN; GLUCOSINOLATE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; ISOMERASE; ISOPROPYLMALATE ISOMERASE; LEUCINE; MALIC ACID DERIVATIVE; METHIONINE; PROTEIN SUBUNIT;

ARABIDOPSIS; ARTICLE; BACTERIUM; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; CHLOROPLAST; CYTOLOGY; ENZYMOLOGY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; NORTHERN BLOTTING; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; PROTOPLAST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOBACCO;

AMINO ACIDS; ARABIDOPSIS; ARABIDOPSIS PROTEINS; BACTERIA; BIOSYNTHETIC PATHWAYS; BLOTTING, NORTHERN; CHLOROPLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, PLANT; GLUCOSINOLATES; GREEN FLUORESCENT PROTEINS; ISOMERASES; LEUCINE; MALATES; METHIONINE; MICROSCOPY, FLUORESCENCE; MOLECULAR STRUCTURE; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; PROTEIN TRANSPORT; PROTOPLASTS; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOBACCO;

ARABIDOPSIS; ARABIDOPSIS THALIANA; BACTERIA (MICROORGANISMS);

EID: 69249203547     PISSN: 01674412     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11103-009-9519-5     Document Type: Article

References (37)

1. JM Alonso AN Stepanova TJ Leisse, et al. 2003 Genome-wide insertional mutagenesis of Arabidopsis thaliana Science 301 653 657
2. S Binder T Knill J Schuster 2007 Branched-chain amino acid metabolism in higher plants Physiol Plant 129 68 78
3. PD Brown JG Tokuhisa M Reichelt J Gershenzon 2003 Variation of glucosinolate accumulation among different organs and developmental stages of Arabidopsis thaliana Phytochemistry 62 471 481
4. T Czechowski M Stitt T Altmann MK Udvardi WR Scheible 2005 Genome-wide identification and testing of superior reference genes for transcript normalization in Arabidopsis Plant Physiol 139 5 17
5. K Däschner I Couee S Binder 2001 The mitochondrial isovaleryl-coenzyme a dehydrogenase of Arabidopsis oxidizes intermediates of leucine and valine catabolism Plant Physiol 126 601 612
6. SJ Davis RD Vierstra 1998 Soluble, highly fluorescent variants of green fluorescent protein (GFP) for use in higher plants Plant Mol Biol 36 521 528
7. J-W de Kraker K Luck S Textor JG Tokuhisa J Gershenzon 2007 Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine Plant Physiol 143 970 986
8. R Diebold J Schuster K Däschner S Binder 2002 The branched-chain amino acid transaminase gene family in Arabidopsis encodes plastid and mitochondrial proteins Plant Physiol 129 540 550
9. KL Falk C Vogel S Textor S Bartram A Hick JA Pickett J Gershenzon 2004 Glucosinolate biosynthesis: demonstration and characterization of the condensing enzyme of the chain elongation cycle in Eruca sativa Phytochemistry 65 1073 1084
10. B Field G Cardon M Traka J Botterman G Vancanneyt R Mithen 2004 Glucosinolate and amino acid biosynthesis in Arabidopsis Plant Physiol 135 828 839
11. J Forner B Weber S Thuss S Wildum S Binder 2007 Mapping of mitochondrial mRNA termini in Arabidopsis thaliana: t-elements contribute to 5′ and 3′ end formation Nucleic Acids Res 35 3676 3692
12. T Gigolashvili R Yatusevich B Berger C Muller UI Flugge 2007 The R2R3-MYB transcription factor HAG1/MYB28 is a regulator of methionine-derived glucosinolate biosynthesis in Arabidopsis thaliana Plant J 51 247 2461
13. CD Grubb S Abel 2006 Glucosinolate metabolism and its control Trends Plant Sci 11 89 100
14. MJ Gruer PJ Artymiuk JR Guest 1997 The aconitase family: three structural variations on a common theme Trends Biochem Sci 22 3 6
15. BA Halkier J Gershenzon 2006 Biology and biochemistry of glucosinolates Annu Rev Plant Biol 57 303 333
16. MY Hirai K Sugiyama Y Sawada, et al. 2007 Omics-based identification of Arabidopsis Myb transcription factors regulating aliphatic glucosinolate biosynthesis Proc Natl Acad Sci USA 104 6478 6483
17. T Knill J Schuster H Reichelt J Gershenzon S Binder 2008 Arabidopsis branched-chain aminotransferase 3 functions in both amino acid and glucosinolate biosynthesis Plant Physiol 146 1028 1039
18. GB Kohlhaw 2003 Leucine biosynthesis in fungi: entering metabolism through the back door Microbiol Mol Biol Rev 67 1 15
19. HU Koop K Steinmuller H Wagner C Rossler C Eibl L Sacher 1996 Integration of foreign sequences into the tobacco plastome via polyethylene glycol-mediated protoplast transformation Planta 199 193 201
20. J Kroymann S Textor JG Tokuhisa KL Falk S Bartram J Gershenzon T Mitchell-Olds 2001 A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chain elongation pathway Plant Physiol 127 1077 1088
21. MG Rosso Y Li N Strizhov B Reiss K Dekker B Weisshaar 2003 An Arabidopsis thaliana T-DNA mutagenized population (GABI-Kat) for flanking sequence tag-based reverse genetics Plant Mol Biol 53 247 259 (Pubitemid 38105653)
22. M Roth 1971 Fluorescence reaction for amino acids Anal Chem 43 880 882
23. Sambrook J, Russel DW (2001) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
24. G Sarwar HG Botting 1993 Evaluation of liquid chromatographic analysis of nutritionally important amino acids in food and physiological samples J Chromatogr 615 1 22
25. J Schuster T Knill H Reichelt J Gershenzon S Binder 2006 BRANCHED-CHAIN AMINOTRANSFERASE 4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis Plant Cell 18 1 16
26. A Sessions E Burke G Presting, et al. 2002 A high-throughput Arabidopsis reverse genetics system Plant Cell 14 2985 2994
27. Singh BK (1999) Biosynthesis of valine, leucine and isoleucine. In: Singh BK (ed) Plant amino acids: biochemistry and biotechnology. Marcel Dekker, New York, pp 227-247
28. IE Sonderby BG Hansen N Bjarnholt C Ticconi BA Halkier DJ Kliebenstein 2007 A systems biology approach identifies a R2R3 MYB gene subfamily with distinct and overlapping functions in regulation of aliphatic glucosinolates PLoS ONE 2 e1322
29. M Strassman LN Ceci 1963 Enzymatic formation of alpha-isopropylmalic acid, an intermediate in leucine biosynthesis J Biol Chem 238 2445 2452
30. S Sureshkumar M Todesco K Schneeberger R Harilal S Balasubramanian D Weigel 2009 A genetic defect caused by a triplet repeat expansion in Arabidopsis thaliana Science 323 1060 1063
31. S Textor J-W de Kraker B Hause J Gershenzon JG Tokuhisa 2007 MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis Plant Physiol 144 60 71
32. The Arabidopsis Genome Initiative 2000 Analysis of the genome sequence of the flowering plant Arabidopsis thaliana Nature 408 796 815
33. EW Underhill LR Wetter MD Chisholm 1973 Biosynthesis of glucosinolates Biochem Soc Symp 38 303 326
34. U Wittstock BA Halkier 2002 Glucosinolate research in the Arabidopsis era Trends Plant Sci 7 263 270
35. RY Xing WB Whitman 1991 Characterization of enzymes of the branched-chain amino acid biosynthetic pathway in Methanococcus spp J Bacteriol 173 2086 2092
36. Y Yasutake M Yao N Sakai T Kirita I Tanaka 2004 Crystal structure of the Pyrococcus horikoshii isopropylmalate isomerase small subunit provides insight into the dual substrate specificity of the enzyme J Mol Biol 344 325 333
37. B Zybailov H Rutschow G Friso A Rudella O Emanuelsson Q Sun KJ van Wijk 2008 Sorting signals, N-terminal modifications and abundance of the chloroplast proteome PLoS ONE 3 e1994