A Human Atrial Natriuretic Peptide Gene Mutation Reveals a Novel Peptide With Enhanced Blood Pressure-Lowering, Renal-Enhancing, and Aldosterone-Suppressing Actions

Journal of the American College of Cardiology

Volumn 54, Issue 11, 2009, Pages 1024-1032

  McKie, Paul M ^a   Cataliotti, Alessandro ^a   Huntley, Brenda K ^a   Martin, Fernando L ^a   Olson, Timothy M ^a   Burnett Jr , John C ^a  

^a MAYO CLINIC   (United States)

Author keywords

aldosterone; angiotensin; blood pressure; heart failure; kidney; natriuretic peptide

Indexed keywords

AMINO ACID; ATRIAL NATRIURETIC FACTOR; ATRIAL NATRIURETIC FACTOR ANTAGONIST; CYCLIC GMP; DIURETIC AGENT; NATRIURETIC PEPTIDE RECEPTOR A;

ANIMAL EXPERIMENT; ARTICLE; ATRIAL NATRIURETIC FACTOR GENE; BLOOD PRESSURE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; FIBROBLAST; GENE MUTATION; GENE SEQUENCE; GENETIC IDENTIFICATION; GENETIC VARIABILITY; GLOMERULUS FILTRATION RATE; HEMODYNAMICS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY BLOOD FLOW; LOW DRUG DOSE; MUTANT; NONHUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ANIMALS; ARRHYTHMIAS, CARDIAC; ATRIAL NATRIURETIC FACTOR; BLOOD PRESSURE; CELL CULTURE TECHNIQUES; CYCLIC GMP; DOGS; FIBROBLASTS; GLOMERULAR FILTRATION RATE; HUMANS; MUTANT PROTEINS; MUTATION; MYOCARDIUM; RENIN-ANGIOTENSIN SYSTEM;

EID: 69249185629     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2009.04.080     Document Type: Article

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