Protective effects of Quercetin on spermatogenesis in streptozotocin- induced diabetic rat

Journal of Medicinal Plants

Volumn 8, Issue SUPPL. 5, 2009, Pages 57-64

  Khaki, A ^a,g   Nouri, M ^b   Fathiazad, F ^b   Ahmadi Ashtiani, H R ^c,d   Rastgar, H ^e   Rezazadeh, Sh ^f  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TARBIAT MODARES UNIVERSITY   (Iran)

^d ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e MINISTRY OF HEALTH AND MEDICAL EDUCATION   (Iran)

^f AVICENNA RESEARCH INSTITUTE   (Iran)

^g NONE   (Iran)

Author keywords

Quercetin; Rat; Spermatogenesis; Streptozotocin

Indexed keywords

ANTIOXIDANT; GLUCOSE; MALONALDEHYDE; OXIDIZED LOW DENSITY LIPOPROTEIN; QUERCETIN; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; EPIDIDYMIS; GLUCOSE BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; SPERMATOGENESIS; SPERMATOZOON; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; STREPTOZOCIN DIABETES; TESTIS; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION;

ANIMALIA; RATTUS;

EID: 69249162710     PISSN: 2717204X     EISSN: 27172058     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Jiang GY. Practical Diabetes. 1st Edition. Beijing: People's Health Publishing House. 1996: 295.
2. Shi-Liang FENG, Shu-Hua LI, Yan WANG, Chang-Chun CHEN, Bin GAO. Effect of ligustrum fruit extract on reproduction in experimental diabetic rats. Asian J. Androl. 2001; 3: 71-73
3. Davis SN.Insulin, Oral Hypoglycemic Agents and the Pharmacology of the Endocrine Pancreas. In: Goodman and Gilmans the Pharmacological Basis of Therapeutics. Brunton, L. L. (Ed.). McGraw-Hill, New York. 2006; 1613-1645
4. Baynes JW, Thorpe SR.Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. J. of Diabetes. 1999; 48: 1-9.
5. Wolff SP, Jiang ZY, Hunt JV.Protein glycation and oxidative stress in diabetes mellitus and ageing. J. Free Radic Biol. Med. 1991; 10: 339-352
6. Palmeira CM, Santos DL, Seica R, Moreno AJ, Santos MS.Enhanced mitochondrial testicular antioxidant capacity in Goto-Kakizaki diabetic rats: role of coenzyme Q. Am. J. Physiol. J. Cell Physiol. 2001; 281: C1023-8.
7. Sexton WJ, Jarow JP.Effect of diabetes mellitus upon male reproductive function. J. of Urology 1997; 49: 508-513 (Pubitemid 27161407)
8. Peluso MR.Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver. J. of Exp. Biol. Med. (Maywood). 2006; 231 (8): 1287-1299
9. Mahesh T, Menon VP.Quercetin alleviates oxidative stress in streptozotocin-induced diabetic rats. J. of Phytother. Res. 2004; 18: 123-127 (Pubitemid 38380605)
10. Shrilatha B, Muralidhara. Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: its progression and genotoxic consequences. J. of Reprod. Toxicol. 2007; 23 (4): 578-587 (Pubitemid 46754745)
11. Khaki A, Fathiazad F, Nouri M, Khaki AA, Jabarikh H, Hammadeh M. Evaluation of Androgenic Activity of Allium cepa on Spermatogenesis in Rat. J. of Folia Morphol. (Warsz). 2009; 68: 45-51.
12. Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. J. of Pharmacol. Res. 2005; 51 (2): 117-123
13. Khaki A, Novin MG, Khaki AA, Nouri M, Sanati E, Nikmanesh M.Comparative study of the effects of gentamicin, neomycin, streptomycin and ofloxacin antibiotics on sperm parameters and testis apoptosis in rats. Pak J. Biol. Sci. 2008; 11 (13): 1683-1689
14. Feng R, He W, Ochi H. A new murine oxidative stress model associated with senescence. J. of Mech Ageing Dev. 2001; 122: 547-559 (Pubitemid 32284936)
15. Quintanilha AT, Packer L, Davies JM, Racanelli TL, Davies KJ. Membrane effects of vitamin E deficiency: bioenergetics and surface charge density studies of skeletal muscle and liver mitochondria. J. of Ann. NY Acad Sci. 1982; 393: 32-47.
16. Huang HFS, Linsenmeyer TA, Li MT, Giglio W, Anesetti R, von Hagen J, Ottenweller JE, Pogach L.Acute effects of spinal cord injury on the pituitary-testicular hormone axis and Sertoli cell functions: a time course study. J. of Androl. 1995; 16: 148-157
17. Foglia VG, Rosner JM, Ramos M, Lema BE. Sexual disturbances in the male diabetic rat. Horm Metab Res. 1969; 1: 72-77
18. Oksanen A.Testicular lesions of streptozotocin diabetic rats. J. of Horm Res. 1975; 6: 138-144
19. Tesone M, Oliveira-Filho RM, Biella de Souza Valle L, Calvo JC, Baraño JLS, Foglia VG, Charreau EH.Androgen receptor in the diabetic rat. J. of Diabetologia. 1980; 18: 385-90.
20. Lin T, Haskell J, Vinson N, Terracio L. Characterization of insulin-like growth factor I receptors of purified Leydig cells and their role in steroidogenesis in primary culture: a comparative study. J. of Endocrinol. 1986; 119: 1641-1647 (Pubitemid 17170531)
21. Feng HL, Jay PD, Sandlow JI, Sparks AET, Sandra A, Zheng LJ. Decreased expression of the c-kit receptor is associated with increased apoptosis in subfertile human testes. J. of Fertil Steril. 1999; 71: 85-89 (Pubitemid 29042348)
22. Steger RW, Rabe MB. The effect of diabetes mellitus on endocrine and reproductive function. J. of Proc Soc. Exp. Biol. Med. 1997; 214: 1-11. (Pubitemid 27051916)
23. Benítez A, Pérez Díaz J.Effect of streptozotocin-diabetes and insulin treatment on regulation of Leydig cell function in the rat. J. of Horm. Metab. Res. 1985; 17: 5-7. (Pubitemid 15150448)
24. Altay B, Cetinkalp S, Doganavsargil B, Hekimgil M, Semerci B. Streptozotocin-induced diabetic effects on spermatogenesis with proliferative cell nuclear antigen immunostaining of adult rat testis. J. of Fertil Steril. 2003; 80 (Suppl 2): 828-831 (Pubitemid 37152400)
25. Seethalakshmi L, Menon M, Diamond D. The effect of streptozotocin-induced diabetes on the neuroendocrine-male reproductive tract axis of the adult rat. J. of Urol. 1987; 138: 190-4. (Pubitemid 17094484)
26. Cameron DF, Murray FT, Drylie DD. Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men. J. of Anat. Rec. 1985; 213: 53-62.
27. Ballester J, Domínguez J, Muñoz MC, Sensat M, Rigau T, Guinovart JJ, Rodríguez-Gil JE. Tungstate treatment improves Leydig cell function in streptozotocin-diabetic rats. J. of Androl. 2005; 26 (6): 706-715 (Pubitemid 41476629)
28. Tang XY, Zhang Q, Dai DZ, Ying HJ, Wang QJ, Dai Y. Effects of strontium fructose 1,6-diphosphate on expression of apoptosis-related genes and oxidative stress in testes of diabetic rats. Int. J. Urol. 2008; 15 (3): 251-256
29. Skibola CF, Smith MT. Potential health impacts of excessive flavonoid intake. J. of Free Radic. Biol. Med. 2000; 29: 375-383
30. Manach C, Morand C, Crespy V, Demigne C, Texier O, Regerat F, Remesy C. Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. J. of FEBS Lett. 1998; 426: 331-336 (Pubitemid 28218374)
31. Bors W, Michel C, Stettmaier K. Antioxidant effects of flavonoids. J. of Biofactors. 1997; 6: 399-402.
32. Naziroǧlu M .Enhanced testicular antioxidant capacity in streptozotocin-induced diabetic rats: protective role of vitamins C and E and selenium. J. of Biol. Trace Elem. Res. 2003; 94(1): 61-72.