Nonalcoholic Fatty Liver Disease Liver Fat Score and Fat Equation to Predict and Quantitate Hepatic Steatosis: Promising But Not Prime Time!

Gastroenterology

Volumn 137, Issue 3, 2009, Pages 772-775

  Chalasani, Naga ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; FATTY ACID; GUANINE; MEMBRANE PROTEIN; METHIONINE; TRIACYLGLYCEROL LIPASE;

CLINICAL FEATURE; CLINICAL PRACTICE; DIET RESTRICTION; DISEASE COURSE; EDITORIAL; FATTY LIVER; HEALTH SURVEY; HUMAN; LIPID STORAGE; LIVER BIOPSY; MEDICAL DECISION MAKING; MEDICAL RESEARCH; NONALCOHOLIC FATTY LIVER; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUALITATIVE ANALYSIS; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 69249145689     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.07.032     Document Type: Editorial

References (17)

1. Vuppalanchi R., and Chalasani N. Nonalcoholic fatty liver disease and non-alcoholic steatohepatitis: selected practical issues in their management. Hepatology 49 (2009) 306-317
2. Cassidy F.H., Yokoo T., Aganovic L., et al. Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis. Radiographics 29 (2009) 231-260
3. Szczepaniak L.S., Babcock E.E., Schick F., et al. Measurement of intracellular triglyceride stores by 1H spectroscopy: validation in vivo. Am J Physiol Endocrinol Metab 276 (1999) 977-989
4. Kotronen A., Peltonen M., Hakkarainen A., et al. Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology 137 (2009) 865-872
5. Romeo S., Kozlitina J., Xing C., et al. Genetic variation in PNLPA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 40 (2008) 1461-1465
6. Longo R., Pollesello P., Ricci C., et al. Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis. J Magn Reson Imag 5 (1995) 281-285
7. Vuppalanchi R., Cummings O.W., Ulbright T., et al. Hepatic steatosis. Relationship among histological, radiological and biochemical assessments. J Clin Gastroenterol 41 (2007) 206-210
8. Prati D., Taioli E., Zanella A., et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 137 (2002) 1-10
9. Kotronen A., Juurinen L., Hakkarainen A., et al. Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects. Diabetes Care 31 (2008) 165-169
10. Chalasani N., Wilson L., Kleiner D.E., et al., NASH Clinical Research Network. Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with nonalcoholic fatty liver disease. J Hepatol 48 (2008) 829-834
11. Choi S.S., and Diehl A.M. Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr Opin Lipidol 19 (2008) 295-300
12. Sookoian S., Castano G.O., Burgueno A.L., et al. A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity. J Lipid Res (2009 May 20) [Epub ahead of print]
13. Kotronen A., Johansson L.E., Johansson L.M., et al. A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetolgia 52 (2009) 1056-1060
14. Steinberg G.R., Kem B.E., Watt M.J., et al. Adipocyte triglyceride lipase expression in human obesity. Am J Physiol Endocrinol Metab 293 (2007) E958-E964
15. Baulande S., Lasnier F., Lucas M., et al. Adiponutrin, a transmembrane protein corresponding to a novel dietary and obesity linked mRNA specifically expressed in the adipose lineage. J Biol Chem 276 (2001) 33336-33344
16. Browning J.D., Szczepaniak L.S., Dobbins R., et al. Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology 40 (2004) 1387-1395
17. Yuan X., Waterworth D., Perry J.R.B., et al. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Human Genetics 83 (2008) 520-528