Intestinal Lipid Absorption, GLP-2, and CD36: Still More Mysteries to Moving Fat

Gastroenterology

Volumn 137, Issue 3, 2009, Pages 775-778

  Newberry, Elizabeth P ^a   Davidson, Nicholas O ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B48; CD36 ANTIGEN; CHYLOMICRON; GLUCAGON LIKE PEPTIDE 2; LIPOPROTEIN; LONG CHAIN FATTY ACID; MESSENGER RNA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; MONOACYLGLYCEROL; SOMATOMEDIN C;

CELL METABOLISM; EDITORIAL; ENDOPLASMIC RETICULUM; GENE DELETION; GLYCOSYLATION; GOLGI COMPLEX; HUMAN; LIPID ABSORPTION; LIPID METABOLISM; LIPID TRANSPORT; NONHUMAN; NUTRITIONAL ASSESSMENT; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MODIFICATION; SIGNAL TRANSDUCTION;

EID: 69249139200     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.07.034     Document Type: Editorial

References (21)

1. Iqbal J., and Hussain M.M. Intestinal lipid absorption. Am J Physiol Endocrinol Metab 296 (2009) E1183-E1194
2. Siddiqi S.A., Siddiqi S., Mahan J., et al. The identification of a novel endoplasmic reticulum to Golgi SNARE complex used by the prechylomicron transport vesicle. J Biol Chem 281 (2006) 20974-20982
3. Drover V.A., Ajmal M., Nassir F., et al. CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood. J Clin Invest 115 (2005) 1290-1297
4. Hsieh J., Longuet C., Maida A., et al. Glucagon-like peptide-2 increases intestinal lipid absorption and chylomicron production via CD36. Gastroenterology 137 (2009) 997-1005
5. Baggio L.L., and Drucker D.J. Biology of incretins: GLP-1 and GIP. Gastroenterology 132 (2007) 2131-2157
6. Meier J.J., Nauck M.A., Pott A., et al. Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans. Gastroenterology 130 (2006) 44-54
7. Yusta B., Holland D., Koehler J.A., et al. ErbB signaling is required for the proliferative actions of GLP-2 in the murine gut. Gastroenterology 137 (2009) 986-996
8. Guan X., Stoll B., Lu X., et al. GLP-2-mediated up-regulation of intestinal blood flow and glucose uptake is nitric oxide-dependent in TPN-fed piglets 1. Gastroenterology 125 (2003) 136-147
9. Hoosdally S.J., Andress E.J., Wooding C., et al. The human scavenger receptor CD36: glycosylation status and its role in trafficking and function. J Biol Chem 284 (2009) 16277-16288
10. Drover V.A., Nguyen D.V., Bastie C.C., et al. CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice. J Biol Chem 283 (2008) 13108-13115
11. Nassir F., Wilson B., Han X., et al. CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine. J Biol Chem 282 (2007) 19493-19501
12. Nauli A.M., Nassir F., Zheng S., et al. CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine. Gastroenterology 131 (2006) 1197-1207
13. Xie Y., Newberry E.P., Young S.G., et al. Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency. J Biol Chem 281 (2006) 4075-4086
14. Luiken J.J., Coort S.L., Willems J., et al. Contraction-induced fatty acid translocase/CD36 translocation in rat cardiac myocytes is mediated through AMP-activated protein kinase signaling. Diabetes 52 (2003) 1627-1634
15. Bonen A., Luiken J.J., Arumugam Y., et al. Acute regulation of fatty acid uptake involves the cellular redistribution of fatty acid translocase. J Biol Chem 275 (2000) 14501-14508
16. Nguyen D.V., Drover V.A., Knopfel M., et al. Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption. J Lipid Res (2009 May 19) [Epub ahead of print]
17. Masuda D., Hirano K., Oku H., et al. Chylomicron remnants are increased in the postprandial state in CD36 deficiency. J Lipid Res 50 (2009) 999-1011
18. Laugerette F., Passilly-Degrace P., et al. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest 115 (2005) 3177-3184
19. Schwartz G.J., Fu J., Astarita G., et al. The lipid messenger OEA links dietary fat intake to satiety. Cell Metab 8 (2008) 281-288
20. Yamashita S., Hirano K., Kuwasako T., et al. Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients. Mol Cell Biochem 299 (2007) 19-22
21. Cohn J.S. Are we ready for a prospective study to investigate the role of chylomicrons in cardiovascular disease?. Atheroscler Suppl 9 (2008) 15-18