A rat model of epilepsy in women: A tool to study physiological interactions between endocrine systems and seizures

Endocrinology

Volumn 150, Issue 9, 2009, Pages 4437-4442

  Scharfman, Helen E ^a,b   Malthankar Phatak, Gauri H ^c   Friedman, Daniel ^a   Pearce, Patrice ^a,b   McCloskey, Daniel P ^d   Harden, Cynthia L ^e   MacLusky, Neil J ^f  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

^e UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DIAZEPAM; PENTOBARBITAL; PILOCARPINE; RALOXIFENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOCRINE FUNCTION; EPILEPTIC STATE; ESTRUS CYCLE; FEMALE; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECURRENT DISEASE;

ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; EPILEPSY; ESTROUS CYCLE; FEMALE; PENTOBARBITAL; PILOCARPINE; RALOXIFENE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; STATUS EPILEPTICUS;

EID: 69249133471     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0135     Document Type: Article

References (36)

1. Foldvary-Schaefer N, Falcone T 2003 Catamenial epilepsy: pathophysiology, diagnosis, and management. Neurology 61:6(Suppl 2):S2-S15
2. Herzog AG, Klein P, Ransil BJ 1997 Three patterns of catamenial epilepsy. Epilepsia 38:1082-1088
3. Rogawski MA 2003 Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsy. Ann Neurol 53:288-291
4. Scharfman HE, MacLusky NJ 2006 The influence of gonadal hormones on neuronal excitability, seizures and epilepsy in the female. Epilepsia 47:1423-1440
5. French JA 2005 Catamenial epilepsy: the elusive condition. Epilepsy Curr 5:113-114
6. Weatherford KJ 1999 Catamenial epilepsy: in search of a clinical entity and its prevalence. J Neurosci Nurs 31:328-331
7. Edwards HE, Burnham WM, Mendonca A, Bowlby DA, MacLusky NJ 1999 Steroid hormones affect limbic after discharge thresholds and kindling rates in adult female rats. Brain Res 838:136-150
8. Amado D, Verreschi IT, Berzaghi MP, Cavalheiro EA 1987 Effects of intrahippocampal injection of kainic acid on estrous cycle in rats. Braz J Med Biol Res 20:829-832
9. Amado D, Cavalheiro EA, Bentivoglio M 1993 Epilepsy and hormonal regulation: the patterns of GnRH and galanin immunoreactivity in the hypothalamus of epileptic female rats. Epilepsy Res 14:149-159
10. Amado D, Cavalheiro EA 1998 Hormonal and gestational parameters in female rats submitted to the pilocarpine model of epilepsy. Epilepsy Res 32:266-274
11. Pathak HR, Weissinger F, Terunuma M, Carlson GC, Hsu FC, Moss SJ, Coulter DA 2007 Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy. J Neurosci 27:14012-14022
12. Scharfman HE, Sollas AL, Goodman JH 2002 Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus. Neuroscience 111:71-81
13. Kumar SS, Jin X, Buckmaster PS, Huguenard JR 2007 Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy. J Neurosci 27:1239-1246
14. Raol YH, Lund IV, Bandyopadhyay S, Zhang G, Roberts DS, Wolfe JH, Russek SJ, Brooks-Kayal AR 2006 Enhancing GABA(A) receptor α1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. J Neurosci 26:11342-11346
15. Scharfman HE, Kim M, Hintz TM, Maclusky NJ 2008 Seizures and reproductive function: insights from an animal model of epilepsy. Ann Neurol 64:687-697
16. Ciriza I, Carrero P, Azcoitia I, Lundeen SG, Garcia-Segura LM 2004 Selective estrogen receptor modulators protect hippocampal neurons from kainic acid excitotoxicity: differences with the effect of estradiol. J Neurobiol 61:209-221
17. Whitten W 1956 Modification of the oestrus cycle of the mouse by external stimuli associated with the male. J Endocrinol 13:299-303
18. Scharfman HE, Mercurio TC, Goodman JH, Wilson MA, MacLusky NJ 2003 Hippocampal excitability increases during the estrous cycle in the rat: a potential role for brain-derived neurotrophic factor. J Neurosci 23:11641-11652
19. Singh KB 2005 Persistent estrus rat models of polycystic ovary disease: an update. Fertil Steril 84(Suppl 2):1228-1234
20. Cyr M, Thibault C, Morissette M, Landry M, Di Paolo T 2001 Estrogen-like activity of tamoxifen and raloxifene on NMDA receptor binding and expression of its subunits in rat brain. Neuropsychopharmacology 25:242-257
21. O'Neill K, Chen S, Brinton RD 2004 Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer's disease. Exp Neurol 185:63-80
22. Racine RJ 1972 Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32:281-294
23. Scharfman HE, Goodman JH, Rigoulot MA, Berger RE, Walling SG, Mercurio TC, Stormes KA, Maclusky NJ 2005 Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine. Exp Neurol 196:73-86
24. Rigoulot MA, Walling SG, Goodman JH, Makarenko N, Nehlig A, Scharfman HE 2004 Hippocampal preservation with extrahippocampal degeneration after pilocarpine-induced status epilepticus followed by pentobarbital anesthesia. Epilepsia 45:49
25. Reddy DS 2004 Role of neurosteroids in catamenial epilepsy. Epilepsy Res 62:99-118
26. Smith SS, Shen H, Gong QH, Zhou X 2007 Neurosteroid regulation of GABA(A) receptors: focus on the α4 and δ subunits. Pharmacol Ther 116:58-76
27. Velísek L, Velísková J 2008 New avenue of research: antiepileptic drug and estradiol neuroprotection in epilepsy. Recent Patents CNS Drug Discov 3:128-137
28. Scharfman HE, MacLusky NJ 2008 Estrogen-growth factor interactions and their contributions to neurological disorders. Headache S 2:S77-S89
29. Dhandapani KM, Brann DW 2002 Protective effects of estrogen and selective estrogen receptor modulators in the brain. Biol Reprod 67:1379-1385
30. Murphy S, McCullough L, Littleton-Kearney M, Hurn P 2003 Estrogen and selective estrogen receptor modulators: neuroprotection in the Women's Health Initiative era. Endocrine 21:17-26
31. Quigg M, Clayburn H, Straume M, Menaker M, Bertram III EH 1999 Hypothalamic neuronal loss and altered circadian rhythm of temperature in a rat model of mesial temporal lobe epilepsy. Epilepsia 40:1688-1696
32. Friedman MN, Geula C, Holmes GL, Herzog AG 2002 GnRH-immunoreactive fiber changes with unilateral amygdala-kindled seizures. Epilepsy Res 52:73-77
33. Oztaçs B, Kaya M 1998 Influence of orchidectomy and ovariectomy on the blood-brain barrier permeability during bicuculline-induced seizures. Horm Metab Res 30:500-503
34. Rainbow TC, Synder L, Berck DJ, McEwen BS 1984 Correlation of muscarinic receptor induction in the ventromedial hypothalamic nucleus with the activation of feminine sexual behavior by estradiol. Neuroendocrinology 39:476-480
35. Cranney A, Adachi JD 2005 Benefit-risk assessment of raloxifene in postmenopausal osteoporosis. Drug Saf 28:721-730
36. Clemett D, Spencer CM 2000 Raloxifene: a review of its use in postmenopausal osteoporosis. Drugs 60:379-411