In vitro transdifferentiation of bone marrow stromal cells into GABAergic-like neurons

Iranian Biomedical Journal

Volumn 13, Issue 3, 2009, Pages 137-143

  Mohammad Gharibani, Payam ^a   Tiraihi, Taki ^a   Arabkheradmand, Jalil ^b  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b Khatam Al Anbia Hospital   (Iran)

Author keywords

Bone marrow stromal cells (BMSC); Cell therapy; GABAergic like neurons; Transdifferentiation

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; MERCAPTOETHANOL; POTASSIUM CHLORIDE; RETINOIC ACID;

ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL CULTURE; CELL THERAPY; CELL TRANSDIFFERENTIATION; CELL TRANSPLANTATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOWN REGULATION; HEMATOPOIETIC STEM CELL; IMMUNOCOMPETENT CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; NEUROBLAST; NEUROFILAMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN INDUCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROMA CELL;

ANIMALS; BONE MARROW CELLS; CELL CULTURE TECHNIQUES; CELL TRANSDIFFERENTIATION; FEMALE; GAMMA-AMINOBUTYRIC ACID; INTERMEDIATE FILAMENT PROTEINS; MERCAPTOETHANOL; NERVE TISSUE PROTEINS; NEUROGENESIS; NEURONS; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; STROMAL CELLS; TRETINOIN;

RATTUS;

EID: 69249129125     PISSN: 1028852X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Banks, GB., Kanjhan, R., Wiese, S., Kneussel, M., Wong, L.M., O'Sullivan, G., Sendtner, M., Bellingham, M.C., Betz, H. and Noakes, P.G. (2005) Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation. J. Neurosci. 25 (5): 1249-1259. (Pubitemid 40268968)
2. Calton, S.M. and Hayes, E.S. (1990) Light microscopic and ultrastructural analysis of GABAimmunoreactive profiles in spinal cord. J. Comp. Neurol. 300 (2): 162-182.
3. Marty, A. and Llano, I. (2005) Excitatory effects of GABA in established brain networks. Trends Neurosc. 28 (6): 284-289. (Pubitemid 40775772)
4. Lanctot, K.L., Herrmann, N., Mazzotta, P., Khan. L.R. and Ingber, N. (2004) GABAergic function in Alzheimer's disease: evidence for dysfunction and potential as a therapeutic target for the treatment of behavioural and psychological symptoms of dementia. Can. J. Psychiatry. 49 (7): 439-453. (Pubitemid 39071365)
5. Miquel, B., José, R. P., Cristina, S., Jordi, P. and Elena, C. (2004) Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease. Exp. Neurol . 190 (1): 42-58.
6. Sanches, R.J. and Song, S. (2000) Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol.164(7):247-256.
7. Woodburry, D., Schwarz, E.J., Prockop, D.J. and Black., I.B. (2000) Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. 61 (4): 364-370.
8. Ross, S.A., McCaffery, P.J., Drager, U.C. and De Luca, L.M. (2000) Retinoids in embryonal development. Physiol. Rev. 80 (3): 1021-1054.
9. Bain, G., Ray, W.J., Yao, M., and Gottlieb, D.I. (1996) Retinoic acid promotes neural and represses mesodermal gene expression in mouse embryonic stem cells in culture. Biochem. Biophys. Res. Commun. 223 (3): 691-694. (Pubitemid 26246135)
10. Suon, S., Yang, M. and Iacovitti, L. (2006) Adult human bone marrow spheres express neuronal traits in vitro and in a rat model of Parkinson's disease. Brain Res. 1106 (1): 46-51. (Pubitemid 44163325)
11. Muñoz-Elías, G., Woodbury, D. and Black, I.B. (2003) Marrow stromal cells, mitosis, and neuronal differentiation: stem cell and precursor functions. Stem Cells. 21 (4): 437-448. (Pubitemid 36793486)
12. Zhai, R.G., Vardinon-Friedman, H., Cases-Langhoff, C., Becker, B., Gundelfinger, E.D., Ziv, N.E. and Garner, C.C. (2001) Assembling the presynaptic active zone: a characterization of an active one precursor vesicle. Neuron. 29 (1): 131-43. (Pubitemid 32108727)
13. Auld, D.S., Mennicken, F., Day, J.C. and Quirion, R. (2001) Neurotrophins differentially enhanced acetyl choline release, acetyl choline content and choline acetyl transferase activity in basal forebrain neurons. J. Neurochem. 77(1): 253-262. (Pubitemid 32245099)
14. Aloe, L., Alleva, E., Böhm, A. and Levi-Montalcini, R. (1986) Aggressive behavior induces release of nerve growth factor from mouse salivary gland into the bloodstream. Proc. Natl. Acad. Sci. USA 83 (16): 6184-6187. (Pubitemid 16000677)
15. Roubelakis, M.G., Pappa, K.I., Bitsika, V., Zagoura, D., Vlahou, A., Papadaki, H.A., Antsaklis, A. and Anagnou, N.P. (2007) Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells. Stem Cells Dev. 16 (6): 931-951.
16. Ni, L., Wen, Y., Peng, X. and Jonakait, G.M. (2001) Antioxidants N-acetylcysteine (NAC) and 2- mercaptoethanol (2-ME) affect the survival and differentiative potential of cholinergic precursors from the embryonic septal nuclei and basal forebrain: involvement of ras signaling. Brain Res. Dev. Brain Res. 130 (2): 207-216. (Pubitemid 33000085)
17. Lu, P., Blesch, A. and Tuszynski, M.H. (2004) Induction of bone marrow stromal cells to neurons: differentiation, transdifferentiation or artifact? J. Neurosci. Res. 77 (2): 174-191. (Pubitemid 38859403)
18. Wagner, M., Han, B. and Jessell, T.M. (1992) Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay. Development 116 (1): 55-66.
19. McCaffery, P. and Drager, U.C. (1994) Hot spots of retinoic acid synthesis in the developing spinal cord. Proc. Natl. Acad. Sci. USA 91 (15): 7194-7197. (Pubitemid 24226829)
20. Maden, M., Sonneveld, E., van der Saag, P.T. and Gale, E. (1998) The distribution of endogenous retinoic acid in the chick embryo: implications for developmental mechanisms. Development 125 (21): 4133-4144. (Pubitemid 28528921)
21. Takahashi, J., Palmer, T.D. and Gage, F.H. (1999) Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult derived neural stem cell cultures. J. Neurobiol. 38 (1): 65-81. (Pubitemid 29016815)
22. Maden, M. (2001) Role and distribution of retinoic acidduring CNS development. Int. Rev. Cytol. 209: 1-77.
23. Kim, B.J., Seo, J.H., Bubien, J.K. and Oh, Y.S. (2002) Differentiation of adult bone marrow stem cells into neuroprogenitor cells in vitro. Neuroreport. 13 (9): 1185-1188.
24. Ishii, K., Katamaya, M., Hori, K., Yodoi, J. and Nakanishi, T. (1993) Effects of 2-mercaptoethanol on survival and differentiation of fetal mouse brain neurons cultured in vitro. Neurosci. Lett. 163 (2): 159-162. (Pubitemid 24005405)
25. Park, S., Lee, K.S., Lee, Y.J., Shin, H.A., Cho, H.Y., Wang, K.C., Kim, Y.S., Lee, H.T., Chung, K.S., Kim, E.Y. and Lim, J. (2004) Generation of dopaminergic neurons in vitro from human embryonic stem cells treated with neurotrophic factors. Neurosci. Lett. 359 (1-2): 99-103. (Pubitemid 38446648)
26. Gavalda, N., Perez-Navarro, E., Gratacos, E., Comella, J.X. and Alberch, J. (2004) Differential involvement of phosphatidylinositol 3-kinase and p42/p44 mitogen activated protein kinase pathways in brain-derived neurotrophic factor-induced trophic effects on cultured striatal neurons. Mol. Cell Neurosci. 25 (3): 460- 468. (Pubitemid 38366411)
27. Haydar, T.F., Wang, F., Schwartz, M.L. and Rakic, P. (2000) Differential modulation of proliferation in the neocortical ventricular and subventricular zones. J. Neurosci. 20 (15): 5764- 5774. (Pubitemid 30636905)
28. Lee, J., Kuroda, S., Shichinohe, H., Ikeda, J., Seki, T., Hida, K., Tada, M., Sawada, K. and Iwasaki, Y. (2003) Migration and differentiation of nuclear fluorescence-labeled bone marrow stromal cells after transplantation into cerebral infarct and spinal cord injury in mice. Neuropathology 23 (3): 169-180. (Pubitemid 37210130)
29. Hung, S.C. (2002) in vitro differentiation of sizesieved stem cells in vitro electrical active neural cells. Stem Cells. 20 (6):522-529.
30. Linyin, F., Chang-Yu, W., Hao Jiang, d., Chikara, O., Keiko Mizuno, a., Millicent, D. and Bai, Lu. (1999) Differential effects of GDNF and BDNF on cultured ventral mesencephalic neurons. Mol Brain Res. 66 (1-2):62-70.