Outdoor air pollution is associated with disease severity in α1-antitrypsin deficiency

European Respiratory Journal

Volumn 34, Issue 2, 2008, Pages 346-353

  Wood, A M ^a   Harrison, R M ^b   Semple, S ^b   Ayres, J G ^b   Stockley, R A ^c  

^a Division of Medical Sciences   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

1 Antitrypsin deficiency; Air pollution; Emphysema; Ozone

Indexed keywords

NITROGEN DIOXIDE; OZONE; SULFUR DIOXIDE;

ADULT; AIR POLLUTION; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; CLINICAL FEATURE; CONCENTRATION (PARAMETERS); CORRELATION ANALYSIS; DISEASE SEVERITY; ENVIRONMENTAL EXPOSURE; FEMALE; GENETIC SUSCEPTIBILITY; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HIGH RISK POPULATION; HUMAN; INDOOR AIR POLLUTION; LONG TERM EXPOSURE; LUNG DIFFUSION; LUNG EMPHYSEMA; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; REGRESSION ANALYSIS; RISK ASSESSMENT; STATISTICAL MODEL;

ADULT; AIR POLLUTANTS; AIR POLLUTION; ALPHA 1-ANTITRYPSIN DEFICIENCY; CROSS-SECTIONAL STUDIES; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; MALE; MIDDLE AGED; NITROGEN DIOXIDE; OZONE; PHENOTYPE; REGRESSION ANALYSIS; SULFUR DIOXIDE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 69249117042     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00087908     Document Type: Article

References (30)

1. Dockery DW, Pope CA 3rd, Xu X, et al. An association between air pollution and mortality in six U.S. cities. N Engl J Med 1993; 329: 1753-1759.
2. Pope CA 3rd, Burnett RT, Thun MJ, et al. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA 2002; 287: 1132-1141.
3. Committee on the Medical Effects of Air Pollution (COMEAP). Report: The quantification of the effects of air pollution on health in the United Kingdom. Department of Health, 1998. www.advisorybodies.doh.gov.uk/COMEAP/ statementsreports/airpol7.htm Date last accessed: October 2008. Date last updated: July 16, 2007.
4. Committee on the Medical Effects of Air Pollution (COMEAP). Long-Term Exposure to Air Pollution: Effect on Mortality. Department of Health, 2007. www.advisorybodies.doh.gov.uk/comeap/statementsreports/longtermeffectsmort2007. htm Date last accessed: October 2008. Date last updated: July 16, 2007.
5. World Health Organization. WHO air quality guidelines: global update 2005. www.cepis.ops-oms.org/bvsea/fulltext/guidelines05.pdf Date last accessed: October 2008. Date last updated: December 29, 2008.
6. American Thoracic Society. What constitutes an adverse health effect of air pollution? Official statement of the American Thoracic Society. Am J Respir Crit Care Med 2000; 161: 665-673.
7. Needham M, Stockley RA. Alpha 1-antitrypsin deficiency. 3: Clinical manifestations and natural history. Thorax 2004; 59: 441-445.
8. Stockley RA, Luisetti M. Alpha-1-Antirypsin Deficiency: The Biochemical Basis of Pulmonary Emphysema. Pavia, IRCCS, 1999. 9 Piitulainen E, Tornling G, Eriksson S. Environmental correlates of impaired lung function in non-smokers with severe alpha 1-antitrypsin deficiency (PiZZ). Thorax 1998; 53: 939-943.
9. 1- Antitrypsin deficiency and lung disease: risk modification by occupational and environmental inhalants. Eur Respir J 2005; 26: 909-917.
10. Li XY, Gilmour PS, Donaldson K, et al. Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro. Thorax 1996; 51: 1216-1222.
11. 1-antitrypsin deficiency: relationship to lung function and health status. Eur Respir J 2001; 17: 1097-1104.
12. Muller NL, Staples CA, Miller RR, et al. "Density mask". An objective method to quantitate emphysema using computed tomography. Chest 1988; 94: 782-787.
13. Holme J, Stockley RA. Radiologic and clinical features of COPD patients with discordant pulmonary physiology: lessons from alpha1-antitrypsin deficiency. Chest 2007; 132: 909-915.
14. Semple SE, Dick F, Cherrie JW. Exposure assessment for a population-based case-control study combining a job-exposure matrix with interview data. Scand J Work Environment Health 2004; 30: 241-248.
15. CASCOT: computer assisted structured coding tool. Warwick Institute for Employment Research. www2.warwick.ac.uk/fac/soc/ier/publications/software/ cascot/
16. EH40/2005 Workplace exposure limits. Table 1: List of approved workplace exposure limits (as consolidated with amendments October 2007). www.hse.gov.uk/coshh/table1.pdf Date last accessed: October 2008.
17. Office for National Statistics. National Statistics Postcode Directory (NSPD). 2006. www.statistics.gov.uk/geography/nspd.asp Date last accessed: October 2008. Date last updated: October 10, 2008.
18. Stedman JR, Kent AJ. An analysis of the spatial patterns of human health related ozone metrics across the UK in 1995, 2003 and 2005. Atmos Environ 2008; 42: 1702-1716.
19. Kent AJ, Grice S, Stedman JR, et al., UK Air Quality modelling for annual reporting 2005 on ambient air quality assessment under Council Directives 96/62/EC, 1999/30/EC and 2000/69/EC. ED48208 - Issue 1. AEA Energy and Environment, 2005.
20. Bower J, Lampert J, Broughton G, et al., Air pollution in the UK: 2005. National Environmental Technology Centre. www.airquality. co.uk/reports/cat05/0612111534-421-AirPollutionUK2005text.pdf Date last accessed: October 2008. Date last updated: August 2006.
21. Elliott P, Shaddick G,Wakefield JC, et al. Long-term associations of outdoor air pollution with mortality in Great Britain. Thorax 2007; 62: 1088-1094.
22. Wallace L. Indoor particles: a review. J Air Waste Manag Assoc 1996; 46: 98-126.
23. Hollingsworth JW, Kleeberger SR, Foster WM. Ozone and pulmonary innate immunity. Proc Am Thorac Soc 2007; 4: 240-246.
24. Devlin RB, McDonnell WF, Becker S, et al. Time-dependent changes of inflammatory mediators in the lungs of humans exposed to 0.4 ppm ozone for 2 hr: a comparison of mediators found in bronchoalveolar lavage fluid 1 and 18 hr after exposure. Toxicol Appl Pharmacol 1996; 138: 176-185.
25. Nadziejko C, Finkelstein I, Balmes JR. Contribution of secretory leukocyte proteinase inhibitor to the antiprotease defense system of the peripheral lung: effect of ozone-induced acute inflammation. Am J Respir Crit Care Med 1995; 152: 1592-1598.
26. Health effects of climate change in the UK 2008: an update of the Department of Health Report 2001/2002. Department of Health/Health Protection Agency, 2008. www.dh.gov.uk/en/Publicationsandstatistics/Publications/ PublicationsPolicyAndGuidance/DH-080702Date last accessed: October 2008. Date last updated: February 12, 2008.
27. Ground level ozone in the 21st century: future trends, impacts and policy implications. Science Policy Report 15/08. The Royal Society, 2008. http://royalsociety.org/displaypagedoc.asp?id531506.
28. Holme J, Stockley JA, Stockley RA. When should we start monitoring alpha 1 antitrypsin deficient subjects? Thorax 2007; 62: A140.
29. Kromhout H, Symanski E, Rappaport SM. A comprehensive evaluation of within- and between-worker components of occupational exposure to chemical agents. Ann Occup Hyg 1993; 37: 253-270.
30. Power C, Elliott J. Cohort profile: 1958 British birth cohort (National Child Development Study). Int J Epidemiol 2006; 35: 34-41.