The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner

Endocrinology

Volumn 150, Issue 9, 2009, Pages 4056-4064

  June, Chunqiu Hou ^a   Williams, Dumaine ^c   Vicogne, Jérôme ^b   Pessin, Jeffrey E ^c  

^a NORTH GENERAL HOSPITAL   (United States)

^b INSTITUT DE BIOLOGIE DE LILLE   (France)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GELDANAMYCIN; GLUCOSE TRANSPORTER 2; HEAT SHOCK PROTEIN 90 INHIBITOR; LACTACYSTIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENDOCYTOSIS; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

3T3-L1 CELLS; ACETYLCYSTEINE; ANIMALS; BENZOQUINONES; CELL MEMBRANE; CHLOROQUINE; ENDOCYTOSIS; EXOCYTOSIS; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE TRANSPORTER TYPE 2; GLUCOSE TRANSPORTER TYPE 4; LACTAMS, MACROCYCLIC; LYSOSOMES; MICE;

EID: 69249098989     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1685     Document Type: Article

References (41)

1. Bryant NJ, Govers R, James DE 2002 Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol 3:267-277
2. Ducluzeau PH, Fletcher LM, Vidal H, Laville M, Tavaré JM 2002 Molecular mechanisms of insulin-stimulated glucose uptake in adipocytes. Diabetes Metab 28:85-92
3. Watson RT, Kanzaki M, Pessin JE 2004 Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes. Endocr Rev 25:177-204
4. Ohtsubo K, Takamatsu S, Minowa MT, Yoshida A, Takeuchi M, Marth JD 2005 Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Cell 123:1307-1321
5. Orci L, Ravazzola M, Baetens D, Inman L, Amherdt M, Peterson RG, Newgard CB, Johnson JH, Unger RH 1990 Evidence that down-regulation of β-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia. Proc Natl Acad Sci USA 87:9953-9957
6. Del Prato S, Tiengo A 2001 The importance of first-phase insulin secretion: implications for the therapy of type 2 diabetes mellitus. Diabetes Metab Res Rev 17:164-174
7. Del Guerra S, Lupi R, Marselli L, Masini M, Bugliani M, Sbrana S, Torri S, Pollera M, Boggi U, Mosca F, Del Prato S, Marchetti P 2005 Functional and molecular defects of pancreatic islets in human type 2 diabetes. Diabetes 54:727-735
8. Prentki M, Matschinsky FM 1987 Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol Rev 67:1185-1248
9. Newgard CB, Lu D, Jensen MV, Schissler J, Boucher A, Burgess S, Sherry AD 2002 Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach. Diabetes 51(Suppl 3):S389-S393
10. Deeney JT, Prentki M, Corkey BE 2000 Metabolic control of β-cell function. Semin Cell Dev Biol 11:267-275
11. Kowluru A 2008 Emerging roles for protein histidine phosphorylation in cellular signal transduction: lessons from the islet β-cell. J Cell Mol Med 12:1885-1908
12. Berggren PO, Larsson O 1994 Ca2+ and pancreatic B-cell function. Biochem Soc Trans 22:12-18
13. Barg S 2003 Mechanisms of exocytosis in insulin-secreting B-cells and glucagon-secreting A-cells. Pharmacol Toxicol 92:3-13
14. Thorens B, Guillam MT, Beermann F, Burcelin R, Jaquet M 2000 Transgenic reexpression of GLUT1 or GLUT2 in pancreatic β cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion. J Biol Chem 275:23751-23758
15. Guillam MT, Hümmler E, Schaerer E, Yeh JI, Birnbaum MJ, Beermann F, Schmidt A, Deriaz N, Thorens B 1997 Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat Genet 17:327-330
16. Guillam MT, Dupraz P, Thorens B 2000 Glucose uptake, utilization, and signaling in GLUT2-null islets. Diabetes 49:1485-1491
17. Thorens B 2003 A gene knockout approach in mice to identify glucose sensors controlling glucose homeostasis. Pflugers Arch 445:482-490
18. Kim Y, Iwashita S, Tamura T, Tokuyama K, Suzuki M 1995 Effect of high-fat diet on the gene expression of pancreatic GLUT2 and glucokinase in rats. Biochem Biophys Res Commun 208:1092-1098
19. Reimer MK, Ahren B 2002 Altered β-cell distribution of pdx-1 and GLUT-2 after a short-term challenge with a high-fat diet in C57BL/6J mice. Diabetes 51(Suppl 1):S138-S143
20. Lilla V, Webb G, Rickenbach K, Maturana A, Steiner DF, Halban PA, Irminger JC 2003 Differential gene expression in well-regulated and dysregulated pancreatic β-cell (MIN6) sublines. Endocrinology 144:1368-1379
21. Capilla E, Suzuki N, Pessin JE, Hou JC 2007 The glucose transporter 4 FQQI motif is necessary for Akt substrate of 160-kilodalton- dependent plasma membrane translocation but not Golgi-localized γ-ear-containing Arf-binding protein-dependent entry into the insulin-responsive storage compartment. Mol Endocrinol 21:3087-3099
22. Khan AH, Capilla E, Hou JC, Watson RT, Smith JR, Pessin JE 2004 Entry of newly synthesized GLUT4 into the insulin-responsive storage compartment is dependent upon both the amino terminus and the large cytoplasmic loop. J Biol Chem 279:37505-37511
23. Brown GK 2000 Glucose transporters: structure, function and consequences of deficiency. J Inherit Metab Dis 23:237-246
24. Pedersen NM, Madshus IH, Haslekås C, Stang E 2008 Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent. Mol Cancer Res 6:491-500
25. Hou JC, Pessin JE 2007 Ins (endocytosis) and outs (exocytosis) of GLUT4 trafficking. Curr Opin Cell Biol 19:466-473
26. Moreno-Sánchez R 1985 Regulation of oxidative phosphorylation in mitochondria by external free Ca2+ concentrations. J Biol Chem 260:4028-4034
27. Aguilar-Bryan L, Bryan J, Nakazaki M 2001 Of mice and men: K(ATP) channels and insulin secretion. Recent Prog Horm Res 56:47-68
28. Henquin JC 2000 Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49:1751-1760
29. Newgard CB, McGarry JD 1995 Metabolic coupling factors in pancreatic β-cell signal transduction. Annu Rev Biochem 64:689-719
30. Iynedjian PB 1993 Mammalian glucokinase and its gene. Biochem J 293(Pt 1):1-13
31. De Vos A, Heimberg H, Quartier E, Huypens P, Bouwens L, Pipeleers D, Schuit F 1995 Human and rat β cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest 96:2489-2495
32. Magnuson MA 1990 Glucokinase gene structure. Functional implications of molecular genetic studies. Diabetes 39:523-527
33. Matschinsky FM 1990 Glucokinase as glucose sensor and metabolic signal generator in pancreatic β-cells and hepatocytes. Diabetes 39:647-652
34. Matschinsky F, Liang Y, Kesavan P, Wang L, Froguel P, Velho G, Cohen D, Permutt MA, Tanizawa Y, Jetton TL, Niswender, K, Magnuson MA 1993 Glucokinase as pancreatic β cell glucose sensor and diabetes gene. J Clin Invest 92:2092-2098
35. Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC 2002 Genetic regulation of metabolic pathways in β-cells disrupted by hyperglycemia. J Biol Chem 277:10912-10921
36. Sargeant RJ, Paquet MR 1993 Effect of insulin on the rates of synthesis and degradation of GLUT1 and GLUT4 glucose transporters in 3T3-L1 adipocytes. Biochem J 290(Pt 3):913-919
37. Watson RT, Pessin JE 2001 Subcellular compartmentalization and trafficking of the insulin-responsive glucose transporter, GLUT4. Exp Cell Res 271:75-83
38. Lalioti V, Vergarajauregui S, Sandoval IV 2001 Targeting motifs in GLUT4. Mol Membr Biol 18:257-264
39. Poitout V, Robertson RP 2008 Glucolipotoxicity: fuel excess and β-cell dysfunction. Endocr Rev 29:351-366
40. Fujimoto Y, Torres TP, Donahue EP, Shiota M 2006 Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats. Diabetes 55:2479-2490
41. Lindmark S, Buren J, Eriksson JW 2006 Insulin resistance, endocrine function and adipokines in type 2 diabetes patients at different glycaemic levels: potential impact for glucotoxicity in vivo. Clin Endocrinol (Oxf) 65:301-309