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247025 Indole inhibitors of human nonpancreatic secretory phospholipase A2. 2. indole-3-acetamides with additional functionality. Dillard RD, Bach NJ, Draheim SE, Berry DR, Carlson DG, Chirgadze NY, Clawson DK, Hartley LW, Johnson LM, Jones ND, McKinney ER et al J MED CHEM 1996 39 26 5137-5158
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247026 Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. indole-3-glyoxamides. Draheim SE, Bach NJ, Dillard RD, Berry DR, Carlson DG, Chirgadze NY, Clawson DK, Hartley LW, Johnson LM, Jones ND, McKinney ER et al J MED CHEM 1996 39 26 5159-5175
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2 inhibitor S-5920-/LY-315920Na Kenji K, Kazushige T, Shingo F, Takashi O, Yozo H INFLAMM RES 1997 46 Suppl 3 S-238
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437753 Safety and efficacy of an sPLA2 inhibitor in treating ulcerative colitis. Lashner B, Korzenik J, Dmitrienko A, Hunt R, Myers S, Krueger K AM J GASTROENTEROL 2001 96 9 S297
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437753 Safety and efficacy of an sPLA2 inhibitor in treating ulcerative colitis. Lashner B, Korzenik J, Dmitrienko A, Hunt R, Myers S, Krueger K AM J GASTROENTEROL 2001 96 9 S297
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456876 Phospholipase A2 in vascular disease. Hurt-Camejo E, Camejo G, Peilot H, Oori K, Kovanen P CIRC RES 2001 89 4 298-304 *Discusses the possible actions of PLA2 enzymes in the arterial wall during atherogenesis
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2 enzymes in the arterial wall during atherogenesis.
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488178 Annual report 2002: Shionogi & Co Ltd. Shionogi & Co Ltd ANNUAL REPORT 2002 March 31
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488178 Annual report 2002: Shionogi & Co Ltd. Shionogi & Co Ltd ANNUAL REPORT 2002 March 31
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593986 Form 10-K 2004 Eli Lilly & Co. Eli Lilly & Co FORM 10-K 2005 March 01
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593986 Form 10-K 2004 Eli Lilly & Co. Eli Lilly & Co FORM 10-K 2005 March 01
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595207 Company website: Shionogi. Shionogi & Co Ltd COMPANY WORLD WIDE WEB SITE 2005 January 31
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595207 Company website: Shionogi. Shionogi & Co Ltd COMPANY WORLD WIDE WEB SITE 2005 January 31
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688686 Anthera licenses portfolio of anti-inflammatory products from Eli Lilly and Company and Shionogi & Co, Ltd. Anthera Pharmaceuticals Inc PRESS RELEASE 2006 September 06
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688686 Anthera licenses portfolio of anti-inflammatory products from Eli Lilly and Company and Shionogi & Co, Ltd. Anthera Pharmaceuticals Inc PRESS RELEASE 2006 September 06
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783686 First patient enrolled in phase 2 'PLASMA' trial with A-002 for patients with coronary atherosclerosis. Anthera Pharmaceuticals Inc PRESS RELEASE 2007 April 13
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783686 First patient enrolled in phase 2 'PLASMA' trial with A-002 for patients with coronary atherosclerosis. Anthera Pharmaceuticals Inc PRESS RELEASE 2007 April 13
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805618 Prevention of atherosclerosis by sPLA2 inhibitor in a mouse model. Trias J, Fraser H, Hislop C WORLD CONGR INFLAMM 2007 8 June 19 Abs FG05.6
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805618 Prevention of atherosclerosis by sPLA2 inhibitor in a mouse model. Trias J, Fraser H, Hislop C WORLD CONGR INFLAMM 2007 8 June 19 Abs FG05.6
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812018 Role of group IIA phospholipase A2 in rat colitis induced by dextran sulfate sodium. Tomita Y, Jyoyama H, Kobayashi M, Kuwabara K, Furue S, Ueno M, Yamada K, Ono T, Teshirogi I, Nomura K, Arita H et al EUR J PHARMACOL 2003 472 1-2 147-158
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812018 Role of group IIA phospholipase A2 in rat colitis induced by dextran sulfate sodium. Tomita Y, Jyoyama H, Kobayashi M, Kuwabara K, Furue S, Ueno M, Yamada K, Ono T, Teshirogi I, Nomura K, Arita H et al EUR J PHARMACOL 2003 472 1-2 147-158
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872442 Anthera enters into manufacturing agreements for varespladib in preparation for pivotal phase III trials. Anthera Pharmaceuticals Inc PRESS RELEASE 2008 January 31
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872442 Anthera enters into manufacturing agreements for varespladib in preparation for pivotal phase III trials. Anthera Pharmaceuticals Inc PRESS RELEASE 2008 January 31
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874396 Anthera enters into manufacturing agreements for varespladib in preparation for pivotal phase III trials. Anthera Pharmaceuticals Inc PRESS RELEAASE 2008 February 05
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874396 Anthera enters into manufacturing agreements for varespladib in preparation for pivotal phase III trials. Anthera Pharmaceuticals Inc PRESS RELEAASE 2008 February 05
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914176 The synergistic inhibition of atherogenesis in ApoE, mice between pravastatin and the sPLA2 inhibitor varespladib A-002, Shaposhnik Z, Wang XP, Trias J, Fraser H, Lusis A ARTERIOSCLER THROMB VASC BIOL 2008 28 6 E53
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2 inhibitor varespladib (A-002). Shaposhnik Z, Wang XP, Trias J, Fraser H, Lusis A ARTERIOSCLER THROMB VASC BIOL 2008 28 6 E53
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920391 Anthera Pharmaceuticals website Anthera Pharmaceuticals Inc COMPANY WORLD WIDE WEB SITE 2008 June 26
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920391 Anthera Pharmaceuticals website Anthera Pharmaceuticals Inc COMPANY WORLD WIDE WEB SITE 2008 June 26
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945755 Anthera completes special protocol assessment with FDA and receives EMEA scientific advice on development path toward varespladib approval. Anthera Pharmaceuticals Inc PRESS RELEASE 2008 September 24
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945755 Anthera completes special protocol assessment with FDA and receives EMEA scientific advice on development path toward varespladib approval. Anthera Pharmaceuticals Inc PRESS RELEASE 2008 September 24
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957673 Effects of a selective inhibitor of secretory phospholipase A2 on low density and very low density lipoprotein subclasses in stable coronary heart disease patients. Rosenson RS, Hislop C, Elliott M, Stasiv Y AM HEART ASSOC SCIENTIFIC SESSIONS 2008 S406-S407 Abs 1928
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2 on low density and very low density lipoprotein subclasses in stable coronary heart disease patients. Rosenson RS, Hislop C, Elliott M, Stasiv Y AM HEART ASSOC SCIENTIFIC SESSIONS 2008 S406-S407 Abs 1928
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975755 Anthera completes enrollment and dosing of varespladib cardiovascular trial. Anthera Pharmaceuticals Inc PRESS RELEASE 2009 January 12
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975755 Anthera completes enrollment and dosing of varespladib cardiovascular trial. Anthera Pharmaceuticals Inc PRESS RELEASE 2009 January 12
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987737 Varespladib A-002, a secretory phospholipase A2 inhibitor, reduces atherosclerosis and aneurysm formation in apoE, mice. Fraser H, Hislop C, Christie RM, Rick HL, Reidy CA, Chouinard ML, Eacho PI, Gould KE, Trias J J CARDIOVASC PHARMACOL 2009 53 1 60-65 *Varespladib methyl reduced aortic atherosclerosis in ApoE , mice fed a high-fat diet. Similarly, in an accelerated atherosclerosis model, varespladib methyl reduced aortic atherosclerosis and attenuated aneurysm formation
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-/- mice fed a high-fat diet. Similarly, in an accelerated atherosclerosis model, varespladib methyl reduced aortic atherosclerosis and attenuated aneurysm formation.
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987750 Effects of 1-H-indole-3-glyoxamide (A-002) on concentration of secretory phospholipase A2 (PLASMA study, A phase II double-blind, randomised, placebo-controlled trial. Rosenson RS, Hislop C, McConnell D, Elliott M, Stasiv Y, Wang N, Waters DD LANCET 2009 373 9664 649-658 **Reports data from a phase II clinical trial (NCT00455546; PLASMA) in patients with stable coronary heart disease who received either placebo or one of four doses of varespladib methyl. Mean sPLA2 IIA and LDL-cholesterol concentrations decreased significantly in the treatment groups compared with the placebo group
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2 IIA and LDL-cholesterol concentrations decreased significantly in the treatment groups compared with the placebo group.
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993311 Effects of a selective inhibitor of secretory phospholipase A2 on atherogenic lipoproteins in stable coronary heart disease patients with and without diabetes. Rosenson RS, Bittman RM, Hislop C J AM COLL CARDIOL 2009 53 10, Suppl 1 Abs 1021-70
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2 on atherogenic lipoproteins in stable coronary heart disease patients with and without diabetes. Rosenson RS, Bittman RM, Hislop C J AM COLL CARDIOL 2009 53 10, Suppl 1 Abs 1021-70
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994982 The synergistic inhibition of atherogenesis in apoE , mice between pravastatin and the sPLA2 inhibitor varespladib A-002, Shaposhnik Z, Wang X, Trias J, Fraser H, Lusis AJ J LIPID RES 2009 50 4 623-629 **Presents results from a study assessing varespladib methyl and pravastatin as monotherapies and in combination in ApoE, mice. Varespladib methyl significantly reduced atherosclerotic lesion formation, whereas pravastatin monotherapy had no effect on the size of atherosclerotic lesions. A synergetic decrease in lesion size was observed when pravastatin was combined with varespladib methyl
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2 inhibitor varespladib (A-002). Shaposhnik Z, Wang X, Trias J, Fraser H, Lusis AJ J LIPID RES 2009 50 4 623-629 **Presents results from a study assessing varespladib methyl and pravastatin as monotherapies and in combination in ApoE-/- mice. Varespladib methyl significantly reduced atherosclerotic lesion formation, whereas pravastatin monotherapy had no effect on the size of atherosclerotic lesions. A synergetic decrease in lesion size was observed when pravastatin was combined with varespladib methyl.
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998636 A-002 varespladib, a phospholipase A2 inhibitor, reduces atherosclerosis in guinea pigs. Leite JO, Vaishnav U, Puglisi M, Fraser H, Trias J, Fernandez ML BMC CARDIOVASC DISORD 2009 9 7 1-9
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2 inhibitor, reduces atherosclerosis in guinea pigs. Leite JO, Vaishnav U, Puglisi M, Fraser H, Trias J, Fernandez ML BMC CARDIOVASC DISORD 2009 9 7 1-9
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1006587 Anthera's varespladib meets primary endpoint in phase 2 FRANCIS trial for the treatment of acute coronary syndrome. Anthera Pharmaceuticals Inc PRESS RELEASE 2009 May 06
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1006587 Anthera's varespladib meets primary endpoint in phase 2 FRANCIS trial for the treatment of acute coronary syndrome. Anthera Pharmaceuticals Inc PRESS RELEASE 2009 May 06
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2. Andreani M, Olivier JL, Berenbaum F, Raymondjean M, Bereziat G BIOCHIM BIOPHYS ACTA MOL CELL BIOL LIPIDS 2000 1488 1-2 149-158
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1019531 Lipoprotein-associated and secretory phospholipase A 2 in cardiovascular disease: The epidemiological evidence. Koenig W, Khuseyinova N Cardiovasc Drugs Ther 2009 23 1 85-92. **Summarizes the current epidemiological evidence on the association between lipoprotein-associated and secretory phospholipase A 2, and the risk of coronary heart disease
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1019532 Interferon-γ induces secretory group IIA phospholipase A2 in human arterial smooth muscle cells Involvement of cell differentiation, STAT-3 activation, and modulation by other cytokines. Peilot H, Rosengren B, Bondjers G, Hurt-Camejo E J BIOL CHEM 2000 275 30 22895-22904
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1019551 A randomized, double-blinded, placebo-controlled clinical trial of LY333013, a selective inhibitor of group II secretory phospholipase A2, in the treatment of rheumatoid arthritis. Bradley JD, Dmitrienko AA, Kivitz AJ, Gluck OS, Weaver AL, Wiesenhutter C, Myers SL, Sides GD J RHEUMATOL 2005 32 3 417-423
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1019556 Impact of a soluble phospholipase A2 inhibitor on inhaled allergen challenge in subjects with asthma. Bowton DL, Dmitrienko AA, Israel E, Zeiher BG, Sides GD J ASTHMA 2005 42 1 65-71
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