Application of antimicrobial photodynamic therapy in periodontal and peri-implant diseases

Periodontology 2000

Volumn 51, Issue 1, 2009, Pages 109-140

  Takasaki, Aristeo A ^a   Aoki, Akira ^a   Mizutani, Koji ^a   Schwarz, Frank ^a   Sculean, Anton ^a   Wang, Chen Ying ^a   Koshy, Geena ^a   Romanos, George ^a   Ishikawa, Isao ^a   Izumi, Yuichi ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

PHOTOSENSITIZING AGENT;

ARTICLE; BACTERIAL INFECTION; BACTERIUM; CLASSIFICATION; DRUG EFFECT; HUMAN; LASER; METHODOLOGY; MICROBIOLOGY; MOUTH; PERIODONTAL DISEASE; PHOTOCHEMOTHERAPY; RADIATION EXPOSURE; TOOTH IMPLANTATION;

BACTERIA; BACTERIAL INFECTIONS; DENTAL IMPLANTS; HUMANS; LASERS; MOUTH; PERIODONTAL DISEASES; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 69149098998     PISSN: 09066713     EISSN: 16000757     Source Type: Journal    
DOI: 10.1111/j.1600-0757.2009.00302.x     Document Type: Article

References (145)

1. AAP. The Research, Science and Therapy Committee of the American Academy of Periodontology. Lasers in periodontics (Academy report), authored by Cohen RE and Ammons WF, revised by Rossman JA. J Periodontol 2002 : 73 : 1231 1239.
2. Adriaens PA, Adriaens LM. Effects of nonsurgical periodontal therapy on hard and soft tissues. Periodontol 2000 2004 : 36 : 121 145.
3. Aghahosseini F, Arbabi-Kalati F, Fashtami LA, Djavid GE, Fateh M, Beitollahi JM. Methylene blue-mediated photodynamic therapy: a possible alternative treatment for oral lichen planus. Lasers Surg Med 2006 : 38 : 33 38.
4. Allison RR, Bagnato VS, Cuenca R, Downie GH, Sibata CH. The future of photodynamic therapy in oncology. Future Oncol 2006 : 2 : 53 71.
5. Amano A. Disruption of epithelial barrier and impairment of cellular function by Porphyromonas gingivalis. Front Biosci 2007 : 12 : 3965 3974.
6. Andersen R, Loebel N, Hammond D, Wilson M. Treatment of periodontal disease by photodisinfection compared to scaling and root planing. J Clin Dent 2007 : 18 : 34 38.
7. Ando Y, Aoki A, Watanabe H, Ishikawa I. Bactericidal effect of erbium YAG laser on periodontopathic bacteria. Lasers Surg Med 1996 : 19 : 190 200.
8. Aoki A, Sasaki KM, Watanabe H, Ishikawa I. Lasers in nonsurgical periodontal therapy. Periodontol 2000 2004 : 36 : 59 97.
9. Aoki A, Takasaki AA, Pourzarandian A, Mizutani K, Ruwanpura SM, Iwasaki K, Noguchi K, Oda S, Watanabe H, Ishikawa I, Izumi Y. Photo-bio-modulation Laser Strategies in Periodontal Therapy. In : Waynant R, Tata DB editor. Proceedings of light-activated tissue regeneration and therapy II. Tomar, Portugal : Springer, 2007 : 181 190.
10. Aoki A, Mizutani K, Takasaki AA, Sasaki KM, Nagai S, Schwarz F, Yoshida I, Eguro T, Zeredo JL, Izumi Y. Current status of clinical laser applications in periodontal therapy. Gen Dent 2008 : 56 : 674 687.
11. Augthun M, Tinschert J, Huber A. In vitro studies on the effect of cleaning methods on different implant surfaces. J Periodontol 1998 : 69 : 857 864.
12. Bertoloni G, Lauro FM, Cortella G, Merchat M. Photosensitizing activity of hematoporphyrin on Staphylococcus aureus cells. Biochim Biophys Acta 2000 : 1475 : 169 174.
13. Bertoloni G, Rossi F, Valduga G, Jori G, van Lier J. Photosensitizing activity of water- and lipid-soluble phthalocyanines on Escherichia coli. FEMS Microbiol Lett 1990 : 59 : 149 155.
14. Bhatti M, MacRobert A, Meghji S, Henderson B, Wilson M. Effect of dosimetric and physiological factors on the lethal photosensitization of Porphyromonas gingivalis in vitro. Photochem Photobiol 1997 : 65 : 1026 1031.
15. Bhatti M, MacRobert A, Meghji S, Henderson B, Wilson M. A study of the uptake of toluidine blue O by Porphyromonas gingivalis and the mechanism of lethal photosensitization. Photochem Photobiol 1998 : 68 : 370 376.
16. Bhatti M, MacRobert A, Henderson B, Shepherd P, Cridland J, Wilson M. Antibody-targeted lethal photosensitization of Porphyromonas gingivalis. Antimicrob Agents Chemother 2000 : 44 : 2615 2618.
17. Bhatti M, MacRobert A, Henderson B, Wilson M. Exposure of Porphyromonas gingivalis to red light in the presence of the light-activated antimicrobial agent toluidine blue decreases membrane fluidity. Curr Microbiol 2002 : 45 : 118 122.
18. Bonsor S, Nichol R, Reid T, Pearson G. Microbiological evaluation of photo-activated disinfection in endodontics (an in vivo study). Br Dent J 2006 : 200 : 337 341, discussion 329.
19. Bonsor S, Pearson G. Current clinical applications of photo-activated disinfection in restorative dentistry. Dent Update 2006 : 150 : 153.
20. Braun A, Dehn C, Krause F, Jepsen S. Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial. J Clin Periodontol 2008 : 35 : 877 884.
21. Brink B, Romanos GE. Mikrobiologische Untersuchungen bei adjuvanten Laseranwendungen in der Parodontologie. Laser Zahnheilkunde 2007 : 2 : 37 42 (in German).
22. Brink B, Romanos GE. Laseranwendung in der Parodontaltherapie. Klinische Daten einer Untersuchung aus der freien Praxis. Laser Zahnheilkunde 2007 : 3 : 165 171 (in German).
23. Busetti A, Soncin M, Jori G, Kenney ME, Rodgers MA. Treatment of malignant melanoma by high-peak-power 1064 nm irradiation followed by photodynamic therapy. Photochem Photobiol 1998 : 68 : 377 381.
24. Buytaert E, Dewaele M, Agostinis P. Molecular effectors of multiple cell death pathways initiated by photodynamic therapy. Biochim Biophys Acta 2007 : 1776 : 86 107.
25. Chan Y, Lai CH. Bactericidal effects of different laser wavelengths on periodontopathic germs in photodynamic therapy. Lasers Med Sci 2003 : 18 : 51 55.
26. Chondros P, Nikolidakis D, Christodoulides N, Rossler R, Gutknecht N, Sculean A. Photodynamic therapy as adjunct to non-surgical periodontal treatment in patients on periodontal maintenance: a randomized controlled clinical trial. Lasers Med Sci 2009 (in press).
27. Christodoulides N, Nikolidakis D, Chondros P, Becker J, Schwarz F, Rossler R, Sculean A. Photodynamic therapy as an adjunct to non-surgical peridoontal treatment: a randomized controlled clinical trial. J Periodontol 2008 : 79 : 1638 1644.
28. Cobb CM, McCawley TK, Killoy WJ. A preliminary study on the effects of the Nd:YAG laser on root surfaces and subgingival microflora in vivo. J Periodontol 1992 : 63 : 701 707.
29. Cobb CM. Lasers in periodontics: a review of the literature. J Periodontol 2006 : 77 : 545 564.
30. Darveau RP, Tanner A, Page RC. The microbial challenge in periodontitis. Periodontol 2000 1997 : 14 : 12 32.
31. de Almeida JM, Theodoro LH, Bosco AF, Nagata MJ, Oshiiwa M, Garcia VG. Influence of photodynamic therapy on the development of ligature-induced periodontitis in rats. J Periodontol 2007 : 78 : 566 575.
32. de Almeida JM, Theodoro LH, Bosco AF, Nagata MJ, Oshiiwa M, Garcia VG. In vivo effect of photodynamic therapy on periodontal bone loss in dental furcations. J Periodontol 2008 : 79 : 1081 1088.
33. de Almeida JM, Theodoro LH, Bosco AF, Nagata MJH, Bonfante S, Garcia VG. Treatment of experimental periodontal disease by photodynamic therapy in diabetes. J Periodontol 2008 : 79 : 2156 2165.
34. de Oliveira RR, Schwartz-Filho HO, Novaes AB Jr., Taba M Jr. Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: a preliminary randomized controlled clinical study. J Periodontol 2007 : 78 : 965 973.
35. Dobson J, Wilson M. Sensitization of oral bacteria in biofilms to killing by light from a low-power laser. Arch Oral Biol 1992 : 37 : 883 887.
36. Donnelly RF, McCarron PA, Tunney MM, David Woolfson A. Potential of photodynamic therapy in treatment of fungal infections of the mouth. Design and characterisation of a mucoadhesive patch containing toluidine blue O. J Photochem Photobiol B 2007 : 86 : 59 69.
37. Dortbudak O, Haas R, Bernhart T, Mailath-Pokorny G. Lethal photosensitization for decontamination of implant surfaces in the treatment of peri-implantitis. Clin Oral Implants Res 2001 : 12 : 104 108.
38. Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M, Moan J, Peng Q. Photodynamic therapy. J Natl Cancer Inst 1998 : 90 : 889 905. (Pubitemid 28304157)
39. Drisko CH. Nonsurgical periodontal therapy. Periodontol 2000 2001 : 25 : 77 88.
40. Fan KF, Hopper C, Speight PM, Buonaccorsi G, MacRobert AJ, Bown SG. Photodynamic therapy using 5-aminolevulinic acid for premalignant and malignant lesions of the oral cavity. Cancer 1996 : 78 : 1374 1383.
41. Fiel RJ, Datta-Gupta N, Mark EH, Howard JC. Induction of DNA damage by porphyrin photosensitizers. Cancer Res 1981 : 41 : 3543 3545.
42. Fimple JL, Fontana CR, Foschi F, Ruggiero K, Song X, Pagonis TC, Tanner AC, Kent R, Doukas AG, Stashenko PP, Soukos NS. Photodynamic treatment of endodontic polymicrobial infection in vitro. J Endod 2008 : 34 : 728 734.
43. Foote CS. Definition of type I and type II photosensitized oxidation. Photochem Photobiol 1991 : 54 : 659.
44. Garcez AS, Nunez SC, Hamblin MR, Ribeiro MS. Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesion. J Endod 2008 : 34 : 138 142.
45. Garcez AS, Ribeiro MS, Tegos GP, Nunez SC, Jorge AO, Hamblin MR. Antimicrobial photodynamic therapy combined with conventional endodontic treatment to eliminate root canal biofilm infection. Lasers Surg Med 2007 : 39 : 59 66.
46. Haas R, Baron M, Dortbudak O, Watzek G. Lethal photosensitization, autogenous bone, and e-PTFE membrane for the treatment of peri-implantitis: preliminary results. Int J Oral Maxillofac Implants 2000 : 15 : 374 382.
47. Haas R, Dortbudak O, Mensdorff-Pouilly N, Mailath G. Elimination of bacteria on different implant surfaces through photosensitization and soft laser. An in vitro study. Clin Oral Implants Res 1997 : 8 : 249 254.
48. Hamblin MR, Hasan T. Photodynamic therapy: a new antimicrobial approach to infectious disease? Photochem Photobiol Sci 2004 : 3 : 436 450.
49. Hayek RR, Araujo NS, Gioso MA, Ferreira J, Baptista-Sobrinho CA, Yamada AM, Ribeiro MS. Comparative study between the effects of photodynamic therapy and conventional therapy on microbial reduction in ligature-induced peri-implantitis in dogs. J Periodontol 2005 : 76 : 1275 1281.
50. Henry CA, Dyer B, Wagner M, Judy M, Matthews JL. Phototoxicity of argon laser irradiation on biofilms of Porphyromonas and Prevotella species. J Photochem Photobiol B 1996 : 34 : 123 128.
51. Henry CA, Judy M, Dyer B, Wagner M, Matthews JL. Sensitivity of Porphyromonas and Prevotella species in liquid media to argon laser. Photochem Photobiol 1995 : 61 : 410 413.
52. Ishikawa I, Aoki A, Takasaki AA. Potential applications of Erbium:YAG laser in periodontics. J Periodontal Res 2004 : 39 : 275 285.
53. Ishikawa I, Aoki A, Takasaki AA, Mizutani K, Sasaki KM, Izumi Y. Application of lasers in periodontics - True Innovation or Myth? Periodontol 2000 2009 : 50 : 90 126.
54. Karring ES, Stavropoulos A, Ellegaard B, Karring T. Treatment of peri-implantitis by the Vector system. Clin Oral Implants Res 2005 : 16 : 288 293.
55. Kennedy JC, Pottier RH, Pross DC. Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol B 1990 : 6 : 143 148.
56. Komerik N, Wilson M, Poole S. The effect of photodynamic action on two virulence factors of gram-negative bacteria. Photochem Photobiol 2000 : 72 : 676 680.
57. Komerik N, Curnow A, MacRobert AJ, Hopper C, Speight PM, Wilson M. Fluorescence biodistribution and photosensitising activity of toluidine blue o on rat buccal mucosa. Lasers Med Sci 2002 : 17 : 86 92.
58. Komerik N, Nakanishi H, MacRobert AJ, Henderson B, Speight P, Wilson M. In vivo killing of Porphyromonas gingivalis by toluidine blue-mediated photosensitization in an animal model. Antimicrob Agents Chemother 2003 : 47 : 932 940.
59. Konopka K, Goslinski T. Photodynamic therapy in dentistry. J Dent Res 2007 : 86 : 694 707.
60. Kreisler M, Christoffers AB, Al-Haj H, Willershausen B, d'Hoedt B. Low level 809-nm diode laser-induced in vitro stimulation of the proliferation of human gingival fibroblasts. Lasers Surg Med 2002 : 30 : 365 369.
61. 2, and GaAIAs laser irradiation on surface properties of endosseous dental implants. Int J Oral Maxillofac Implants 2002 : 17 : 202 211.
62. Kreisler M, Kohnen W, Marinello C, Gotz H, Duschner H, Jansen B, d'Hoedt B. Bactericidal effect of the Er:YAG laser on dental implant surfaces: an in vitro study. J Periodontol 2002 : 73 : 1292 1298.
63. Kubler A, Haase T, Rheinwald M, Barth T, Muhling J. Treatment of oral leukoplakia by topical application of 5-aminolevulinic acid. Int J Oral Maxillofac Surg 1998 : 27 : 466 469.
64. Lambrecht B, Mohr H, Knuver-Hopf J, Schmitt H. Photoinactivation of viruses in human fresh plasma by phenothiazine dyes in combination with visible light. Vox Sang 1991 : 60 : 207 213.
65. Listgarten MA, Lai CH. Comparative microbiological characteristics of failing implants and periodontally diseased teeth. J Periodontol 1999 : 70 : 431 437.
66. Luan XL, Qin YL, Bi LJ, Hu CY, Zhang ZG, Lin J, Zhou CN. Histological evaluation of the safety of toluidine blue-mediated photosensitization to periodontal tissues in mice. Lasers Med Sci 2009 : 24 : 162 166.
67. Lundgren J, Olofsson J, Hellquist H. Toluidine blue. An aid in the microlaryngoscopic diagnosis of glottic lesions? Arch Otolaryngol 1979 : 105 : 169 174.
68. Magnusson I, Low SB, McArthur WP, Marks RG, Walker CB, Maruniak J, Taylor M, Padgett P, Jung J, Clark WB. Treatment of subjects with refractory periodontal disease. J Clin Periodontol 1994 : 21 : 628 637.
69. Maisch T, Szeimies RM, Jori G, Abels C. Antibacterial photodynamic therapy in dermatology. Photochem Photobiol Sci 2004 : 3 : 907 917.
70. Maisch T. Anti-microbial photodynamic therapy: useful in the future? Lasers Med Sci 2007 : 22 : 83 91.
71. Malik Z, Ladan H, Nitzan Y. Photodynamic inactivation of Gram-negative bacteria: problems and possible solutions. J Photochem Photobiol B 1992 : 14 : 262 266.
72. Matevski D, Weersink R, Tenenbaum HC, Wilson B, Ellen RP, Lepine G. Lethal photosensitization of periodontal pathogens by a red-filtered Xenon lamp in vitro. J Periodontal Res 2003 : 38 : 428 435.
73. Meisel P, Kocher T. Photodynamic therapy for periodontal diseases: state of the art. J Photochem Photobiol B 2005 : 79 : 159 170.
74. Merchat M, Bertolini G, Giacomini P, Villanueva A, Jori G. Meso-substituted cationic porphyrins as efficient photosensitizers of gram-positive and gram-negative bacteria. J Photochem Photobiol B 1996 : 32 : 153 157. (Pubitemid 26127371)
75. Merchat M, Spikes JD, Bertoloni G, Jori G. Studies on the mechanism of bacteria photosensitization by meso-substituted cationic porphyrins. J Photochem Photobiol B 1996 : 35 : 149 157. (Pubitemid 26383615)
76. Meyer DH, Sreenivasan PK, Fives-Taylor PM. Evidence for invasion of a human oral cell line by Actinobacillus actinomycetemcomitans. Infect Immun 1991 : 59 : 2719 2726.
77. Millson CE, Wilson M, Macrobert AJ, Bedwell J, Bown SG. The killing of Helicobacter pylori by low-power laser light in the presence of a photosensitiser. J Med Microbiol 1996 : 44 : 245 252.
78. Moan J, Berg K. The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen. Photochem Photobiol 1991 : 53 : 549 553.
79. Mohr H, Lambrecht B, Schmitt H. Photo-inactivation of viruses in therapeutical plasma. Dev Biol Stand 1993 : 81 : 177 183.
80. Mombelli A, Lang NP. Antimicrobial treatment of peri-implant infections. Clin Oral Implants Res 1992 : 3 : 162 168.
81. Mombelli A, van Oosten MA, Schurch E Jr., Land NP. The microbiota associated with successful or failing osseointegrated titanium implants. Oral Microbiol Immunol 1987 : 2 : 145 151.
82. Moritz A, Gutknecht N, Doertbudak O, Goharkhay K, Schoop U, Schauer P, Sperr W. Bacterial reduction in periodontal pockets through irradiation with a diode laser: a pilot study. J Clin Laser Med Surg 1997 : 15 : 33 37.
83. Morlock BJ, Pippin DJ, Cobb CM, Killoy WJ, Rapley JW. The effect of Nd:YAG laser exposure on root surfaces when used as an adjunct to root planing: an in vitro study. J Periodontol 1992 : 63 : 637 641.
84. 2 laser. Clin Oral Implants Res 1999 : 10 : 54 61.
85. Nikaido H. Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 1994 : 264 : 382 388.
86. Ochsner M. Photophysical and photobiological processes in the photodynamic therapy of tumours. J Photochem Photobiol B 1997 : 39 : 1 18.
87. Ojetti V, Persiani R, Nista EC, Rausei S, Lecca G, Migneco A, Cananzi FC, Cammarota G, D'Ugo D, Gasbarrini G, Gasbarrini A. A case-control study comparing methylene blue directed biopsies and random biopsies for detecting pre-cancerous lesions in the follow-up of gastric cancer patients. Eur Rev Med Pharmacol Sci 2007 : 11 : 291 296.
88. O'Neill JF, Hope CK, Wilson M. Oral bacteria in multi-species biofilms can be killed by red light in the presence of toluidine blue. Lasers Surg Med 2002 : 31 : 86 90.
89. 2 lasers and temperature changes of titanium implants. J Periodontol 1995 : 66 : 1017 1024.
90. Panjehpour M, Overholt BF, DeNovo RC, Petersen MG, Sneed RE. Comparative study between pulsed and continuous wave lasers for Photofrin photodynamic therapy. Lasers Surg Med 1993 : 13 : 296 304.
91. Paulino T, Ribeiro K, Thedei GJ, Tedesco A, Ciancaglini P. Use of hand held photopolymerizer to photoinactivate Streptococcus mutans. Arch Oral Biol 2005 : 50 : 353 359.
92. Pe MB, Sano K, Inokuchi T. Effects of photodynamic therapy in the normal mouse tongue. J Oral Maxillofac Surg 1993 : 51 : 1129 1134.
93. Peng Q, Moan J, Nesland JM. Correlation of subcellular and intratumoral photosensitizer localization with ultrastructural features after photodynamic therapy. Ultrastruct Pathol 1996 : 20 : 109 129.
94. Qadri T, Miranda L, Tuner J, Gustafsson A. The short-term effects of low-level lasers as adjunct therapy in the treatment of periodontal inflammation. J Clin Periodontol 2005 : 32 : 714 719.
95. Qin Y, Luan X, Bi L, He G, Bai X, Zhou C, Zhang Z. Toluidine blue-mediated photoinactivation of periodontal pathogens from supragingival plaques. Lasers Med Sci 2008 : 23 : 49 54.
96. Qin YL, Luan XL, Bi LJ, Sheng YQ, Zhou CN, Zhang ZG. Comparison of toluidine blue-mediated photodynamic therapy and conventional scaling treatment for periodontitis in rats. J Periodontal Res 2008 : 43 : 162 167.
97. Quirynen M, Teughels W, De Soete M, van Steenberghe D. Topical antiseptics and antibiotics in the initial therapy of chronic adult periodontitis: microbiological aspects. Periodontol 2000 2002 : 28 : 72 90.
98. Radvar M, MacFarlane TW, MacKenzie D, Whitters CJ, Payne AP, Kinane DF. An evaluation of the Nd:YAG laser in periodontal pocket therapy. Br Dent J 1996 : 180 : 57 62.
99. Romanos GE, Everts H, Nentwig GH. Effects of diode and Nd:YAG laser irradiation on titanium discs: a scanning electron microscope examination. J Periodontol 2000 : 71 : 810 815.
100. Roos-Jansaker AM, Renvert S, Egelberg J. Treatment of peri-implant infections: a literature review. J Clin Periodontol 2003 : 30 : 467 485.
101. Rovaldi CR, Pievsky A, Sole NA, Friden PM, Rothstein DM, Spacciapoli P. Photoactive porphyrin derivative with broad-spectrum activity against oral pathogens in vitro. Antimicrob Agents Chemother 2000 : 44 : 3364 3367.
102. Sarkar S, Wilson M. Lethal photosensitization of bacteria in subgingival plaque from patients with chronic periodontitis. J Periodontal Res 1993 : 28 : 204 210.
103. Schafer M, Schmitz C, Horneck G. High sensitivity of Deinococcus radiodurans to photodynamically-produced singlet oxygen. Int J Radiat Biol 1998 : 74 : 249 253.
104. Schuckert KH, Jopp S, Muller U. De novo grown bone on exposed implant surfaces using photodynamic therapy and recombinant human bone morphogenetic protein-2: case report. Implant Dent 2006 : 15 : 361 365.
105. Schwarz F, Bieling K, Bonsmann M, Latz T, Becker J. Nonsurgical treatment of moderate and advanced periimplantitis lesions: a controlled clinical study. Clin Oral Investig 2006 : 10 : 279 288.
106. Schwarz F, Bieling K, Nuesry E, Sculean A, Becker J. Clinical and histological healing pattern of peri-implantitis lesions following non-surgical treatment with an Er:YAG laser. Lasers Surg Med 2006 : 38 : 663 671.
107. Schwarz F, Jepsen S, Herten M, Sager M, Rothamel D, Becker J. Influence of different treatment approaches on non-submerged and submerged healing of ligature induced peri-implantitis lesions: an experimental study in dogs. J Clin Periodontol 2006 : 33 : 584 595.
108. Schwarz F, Sculean A, Romanos G, Herten M, Horn N, Scherbaum W, Becker J. Influence of different treatment approaches on the removal of early plaque biofilms and the viability of SAOS2 osteoblasts grown on titanium implants. Clin Oral Investig 2005 : 9 : 111 117.
109. Schwarz F, Sculean A, Rothamel D, Schwenzer K, Georg T, Becker J. Clinical evaluation of an Er:YAG laser for nonsurgical treatment of peri-implantitis: a pilot study. Clin Oral Implants Res 2005 : 16 : 44 52. (Pubitemid 41595035)
110. Sculean A, Schwarz F, Becker J. Anti-infective therapy with an Er:YAG laser: influence on peri-implant healing. Expert Rev Med Devices 2005 : 2 : 267 276.
111. Sharman WM, Allen CM, van Lier JE. Photodynamic therapeutics: basic principles and clinical applications. Drug Discov Today 1999 : 4 : 507 517.
112. Shibli J A, Martins M C, Nociti F H Jr., Garcia V G, Marcantonio E Jr. Treatment of ligature-induced peri-implantitis by lethal photosensitization and guided bone regeneration: a preliminary histologic study in dogs. J Periodontol 2003 : 74 : 338 345.
113. Shibli JA, Martins MC, Ribeiro FS, Garcia VG, Nociti FH Jr., Marcantonio E Jr. Lethal photosensitization and guided bone regeneration in treatment of peri-implantitis: an experimental study in dogs. Clin Oral Implants Res 2006 : 17 : 273 281.
114. Shibli JA, Martins MC, Theodoro LH, Lotufo RF, Garcia VG, Marcantonio EJ. Lethal photosensitization in microbiological treatment of ligature-induced peri-implantitis: a preliminary study in dogs. J Oral Sci 2003 : 45 : 17 23.
115. Sigusch BW, Pfitzner A, Albrecht V, Glockmann E. Efficacy of photodynamic therapy on inflammatory signs and two selected periodontopathogenic species in a beagle dog model. J Periodontol 2005 : 76 : 1100 1105.
116. Slots J. The search for effective, safe and affordable periodontal therapy. Periodontol 2000 2002 : 28 : 9 11.
117. Smetana Z, Malik Z, Orenstein A, Mendelson E, Ben-Hur E. Treatment of viral infections with 5-aminolevulinic acid and light. Lasers Surg Med 1997 : 21 : 351 358.
118. Smetana Z, Ben-Hur E, Mendelson E, Salzberg S, Wagner P, Malik Z. Herpes simplex virus proteins are damaged following photodynamic inactivation with phthalocyanines. J Photochem Photobiol B 1998 : 44 : 77 83.
119. Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets. Periodontol 2000 2002 : 28 : 12 55.
120. Soukos NS, Wilson M, Burns T, Speight PM. Photodynamic effects of toluidine blue on human oral keratinocytes and fibroblasts and Streptococcus sanguis evaluated in vitro. Lasers Surg Med 1996 : 18 : 253 259.
121. Soukos NS, Ximenez-Fyvie LA, Hamblin MR, Socransky SS, Hasan T. Targeted antimicrobial photochemotherapy. Antimicrob Agents Chemother 1998 : 42 : 2595 2601.
122. Soukos NS, Mulholland SE, Socransky SS, Doukas AG. Photodestruction of human dental plaque bacteria: enhancement of the photodynamic effect by photomechanical waves in an oral biofilm model. Lasers Surg Med 2003 : 33 : 161 168.
123. Soukos NS, Som S, Abernethy AD, Ruggiero K, Dunham J, Lee C, Doukas AG, Goodson JM. Phototargeting oral black-pigmented bacteria. Antimicrob Agents Chemother 2005 : 49 : 1391 1396.
124. Takasaki AA, Aoki A, Mizutani K, Kikuchi S, Oda S, Ishikawa I. Er:YAG laser therapy for peri-implant infection: a histological study. Lasers Med Sci 2007 : 22 : 143 157.
125. Teichert MC, Jones JW, Usacheva MN, Biel MA. Treatment of oral candidiasis with methylene blue-mediated photodynamic therapy in an immunodeficient murine model. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 : 93 : 155 160.
126. Teles RP, Haffajee AD, Socransky SS. Microbiological goals of periodontal therapy. Periodontol 2000 2006 : 42 : 180 218.
127. Thiha K, Takeuchi Y, Umeda M, Huang Y, Ohnishi M, Ishikawa I. Identification of periodontopathic bacteria in gingival tissue of Japanese periodontitis patients. Oral Microbiol Immunol 2007 : 22 : 201 207.
128. Umeda M, Takeuchi Y, Noguchi K, Huang Y, Koshy G, Ishikawa I. Effects of nonsurgical periodontal therapy on the microbiota. Periodontol 2000 2004 : 36 : 98 120. (Pubitemid 41694990)
129. Usacheva MN, Teichert MC, Biel MA. Comparison of the methylene blue and toluidine blue photobactericidal efficacy against gram-positive and gram-negative microorganisms. Lasers Surg Med 2001 : 29 : 165 173.
130. Usacheva MN, Teichert MC, Biel MA. The interaction of lipopolysaccharides with phenothiazine dyes. Lasers Surg Med 2003 : 33 : 311 319.
131. Usacheva MN, Teichert MC, Sievert CE, Biel MA. Effect of Ca+ on the photobactericidal efficacy of methylene blue and toluidine blue against gram-negative bacteria and the dye affinity for lipopolysaccharides. Lasers Surg Med 2006 : 38 : 946 954.
132. van der Meij EH, Schepman KP, van der Waal I. The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003 : 96 : 164 171.
133. von Tappeiner H, Jodlbauer A. Uber die Wirkung der photodynamischen (fluorescierenden) Stoffe auf Protozoen und Enzyme. Dtsch Arch Klin Med 1904 : 39 : 427 487.
134. Wainwright M. Photodynamic antimicrobial chemotherapy (PACT). J Antimicrob Chemother 1998 : 42 : 13 28.
135. Walker C. The acquisition of antibiotic resistance in the periodontal microflora. Periodontol 2000 1996 : 10 : 79 80.
136. Walker C, Karpinia K. Rationale for use of antibiotics in periodontics. J Periodontol 2002 : 73 : 1188 1196.
137. Wigdor H, Abt E, Ashrafi S, Walsh JT Jr. The effect of lasers on dental hard tissues. J Am Dent Assoc 1993 : 124 : 65 70.
138. Williams J, Pearson G, Colles M, Wilson M. The photo-activated antibacterial action of toluidine blue O in a collagen matrix and in carious dentine. Caries Res 2004 : 38 : 530 536.
139. Wilson M. Lethal photosensitisation of oral bacteria and its potential application in the photodynamic therapy of oral infections. Photochem Photobiol Sci 2004 : 3 : 412 418.
140. Wilson M, Burns T, Pratten J, Pearson GJ. Bacteria in supragingival plaque samples can be killed by low-power laser light in the presence of a photosensitizer. J Appl Bacteriol 1995 : 78 : 569 574.
141. Wilson M, Dobson J, Sarkar S. Sensitization of periodontopathogenic bacteria to killing by light from a low-power laser. Oral Microbiol Immunol 1993 : 8 : 182 187.
142. Wilson M, Mia N. Sensitisation of Candida albicans to killing by low-power laser light. J Oral Pathol Med 1993 : 22 : 354 357. (Pubitemid 23353475)
143. Yilmaz S, Kuru B, Kuru L, Noyan U, Argun D, Kadir T. Effect of gallium arsenide diode laser on human periodontal disease: a microbiological and clinical study. Lasers Surg Med 2002 : 30 : 60 66.
144. Yu CH, Chen HM, Hung HY, Cheng SJ, Tsai T, Chiang CP. Photodynamic therapy outcome for oral verrucous hyperplasia depends on the clinical appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion. Oral Oncol 2008 : 44 : 595 600.
145. Zanin IC, Goncalves RB, Junior AB, Hope CK, Pratten J. Susceptibility of Streptococcus mutans biofilms to photodynamic therapy: an in vitro study. J Antimicrob Chemother 2005 : 56 : 324 330.