Removal of endogenous retrovirus-like particles from CHO-cell derived products using Q sepharose fast flow chromatography

Biotechnology Progress

Volumn 25, Issue 4, 2009, Pages 1194-1197

  Strauss, Daniel M ^a,c   Lute, Scott ^b   Brorson, Kurt ^b   Blank, Gregory S ^a   Chen, Qi ^a   Yang, Bin ^a  

^a GENENTECH INC   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Anion exchange chromatography (AEX); Endogenous retrovirus like particle (RVLP); Monoclonal antibody production; Q sepharose fast flow (QSFF); Viral safety

Indexed keywords

ANION EXCHANGE CHROMATOGRAPHY (AEX); ENDOGENOUS RETROVIRUS-LIKE PARTICLE (RVLP); MONOCLONAL ANTIBODY PRODUCTION; Q SEPHAROSE FAST FLOW (QSFF); VIRAL SAFETY;

ALLERGIES; CELL CULTURE; CELL MEMBRANES; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; MERGERS AND ACQUISITIONS; MONOCLONAL ANTIBODIES; NEGATIVE IONS; SURFACE PLASMON RESONANCE;

GEL PERMEATION CHROMATOGRAPHY;

DRUG; MONOCLONAL ANTIBODY; SEPHAROSE;

ANIMAL; CHEMISTRY; CHO CELL; CONFERENCE PAPER; CRICETULUS; DRUG CONTAMINATION; ENDOGENOUS RETROVIRUS; EVALUATION; HAMSTER; ION EXCHANGE CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METHODOLOGY; PROTEIN BINDING;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CHROMATOGRAPHY, ION EXCHANGE; CRICETINAE; CRICETULUS; DRUG CONTAMINATION; ENDOGENOUS RETROVIRUSES; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; SEPHAROSE;

CRICETULUS GRISEUS;

EID: 69149097342     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1002/btpr.249     Document Type: Conference Paper

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