Effects of recombinant human activated protein C on the fibrinolytic system of patients undergoing conventional or tight glycemic control

Minerva Anestesiologica

Volumn 75, Issue 7-8, 2009, Pages 417-426

  Polli, F ^a   Savioli, M ^b   Cugno, M ^a   Taccone, R ^b   Bellani, G ^c,d   Spanu, R ^e   Pesenti, A ^c,d   Iapichino, G ^a,e   Gattinoni, L ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b IRCCS   (Italy)

^c Clinica Pediatrica Milano Bicocca   (Italy)

^d UNIVERSITY OF MILANO BICOCCA   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

Blood glucose; Fibrinolysis; Plasminogen activator inhibitor 1; Recombinant human activated protein C; Sepsis; Shock, septic

Indexed keywords

ACTIVATED PROTEIN C; C REACTIVE PROTEIN; INTERLEUKIN 6; PLASMINOGEN ACTIVATOR INHIBITOR 1;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; BLOOD LEVEL; CONTROLLED STUDY; FEMALE; FIBRINOLYSIS; GLYCEMIC CONTROL; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIPLE ORGAN FAILURE; SEPSIS; SEPTIC SHOCK;

AGED; BLOOD GLUCOSE; FEMALE; FIBRINOLYSIS; FIBRINOLYTIC AGENTS; HUMANS; ITALY; MALE; MIDDLE AGED; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN C; RECOMBINANT PROTEINS; SEPSIS; TREATMENT OUTCOME;

EID: 69149088637     PISSN: 03759393     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Gattinoni L, Vagginelli F, Taccone P, Carlesso E, Bertoja E. Sepsis: state of the art. Minerva Anestesiol 2003;69:539-561
2. Esmon CT. The interactions between inflammation and coagulation. Br J Haematol 2005;131:417-430
3. Cohen J. The immunopathogenesis of sepsis. Nature 2002;420:885-891
4. Levi M, ten Cate H. Disseminated intravascular coagulation. N Engl J Med 1999;341:586-592 (Pubitemid 29384168)
5. Savioli M, Cugno M, Polli F, Taccone P, Bellani G, Spanu P et al. Tight glycemic control may favor fibrinolysis in septic patients. Crit Care Med. 2009;37:424-431
6. Vincent JL, Bernard GR, Beale R, Doig C, Putensen C, Dhainaut JF et al. Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment. Crit Care Med 2005;33:2266-2277 (Pubitemid 41437481)
7. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001;344:699-709. (Pubitemid 32204987)
8. Vincent JL. Drotrecogin alfa (activated) in the treatment of severe sepsis. Expert Rev Anti Infect Ther 2006;4:537-547 (Pubitemid 44523934)
9. Suter PM. My brother has severe sepsis-should he receive Xigris? Minerva Anestesiol 2007;73:647-650
10. Macias WL, Yan SB, Williams MD, Um SL, Sandusky GE, Ballard DW et al. New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated). Crit Care 2005;9 Suppl 4:S38-S45.
11. D'Angelo A, Delia VP, Giudici D, Vigano DS. [Protein C and coagulation in sepsis]. Minerva Anestesiol 2004;70:339-50.
12. Esmon CT. Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation. Crit Care Med 2001 ;29:S48-S51.
13. Urano T, Castellino FJ, Ihara H, Suzuki Y, Ohta M, Suzuki K et al. Activated protein C attenuates coagulation-associated over-expression of fibrinolytic activity by suppressing the thrombin-dependent inactivation of PAI-1. J Thromb Haemost 2003; 1:2615-2620
14. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I etal. Intensive insulin therapy in the medical ICU. N Engl J Med 2006;354:449-461
15. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Scherz M etal. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001;345:1359-1367
16. Grant PJ. Diabetes mellitus as a prothrombotic condition. J Intern Med 2007;262:157-172
17. Juhan-Vague I, Roul C, Alessi MC, Ardissone JP, Heim M, Vague P. Increased plasminogen activator inhibitor activity in non insulin dependent diabetic patients-relationship with plasma insulin. Thromb Haemost 1989;61:370-373 (Pubitemid 19168139)
18. Vincent JL, Moreno R.Takala J, Willatts S, De Mendonca A, Bruining H et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996;22:707-710 (Pubitemid 26254283)
19. Mannucci PM, Bernardinelli L, Foco L, Galli M, Ribichini F, Tubaro M et al. Tissue plasminogen activator antigen is strongly associated with myocardial infarction in young women. J Thromb Haemost 2005;3:280-286 (Pubitemid 41623615)
20. de Pont AC, Bakhtiari K, Hutten BA, de Jonge E, Vroom MB, Meijers JC etal. Recombinant human activated protein C resets thrombin generation in patients with severe sepsis: a case control study. Crit Care 2005;9:R490-R497.
21. Dhainaut JF, Yan SB, Margolis BD, Lorente JA, Russell JA, Freebairn RC et al. Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis. Thromb Haemost 2003;90:642-653 (Pubitemid 37287632)
22. Sakata Y, Loskutoff DJ, Gladson CL, Hekman CM, Griffin JH. Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor. Blood 1986;68:1218-1223 (Pubitemid 17228795)
23. Bonfigli AR, Sirolla C, Cenerelli S, Marra M, Boemi M, Franceschi C etal. Plasminogen activator inhibitor-1 plasma level increases with age in subjects with the 4G allele at position -675 in the promoter region. Thromb Haemost 2004;92:1164-1165
24. Krishnamurti C, Tang DB, Barr CF, Alvin CM. Plasminogen activator and plasminogen activator inhibitor activities in a reference population. Am J Clin Pathol 1988;89:742-752 (Pubitemid 18149212)
25. Takada Y, Takada A. Plasma levels of t-PA free PAI-1 and a complex of t-PA with PAI-1 in human males and females at various ages. Thromb Res 1989;55:601-609 (Pubitemid 19248252)
26. Kain K, Carter AM, Bamford JM, Grant PJ, Catto AJ. Gender differences in coagulation and fibrinolysis in white subjects with acute ischemic stroke. J Thromb Haemost 2003; 1: 390-392