Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development

Development

Volumn 136, Issue 15, 2009, Pages 2601-2611

  Ng, Anthony ^a   Uribe, Rosa A ^a   Yieh, Leah ^a   Nuckels, Richard ^a   Gross, Jeffrey M ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

De novo purine synthesis; Microphthalmia; Pigmentation; Zebrafish

Indexed keywords

GENE PRODUCT; GUANOSINE TRIPHOSPHATE; PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE PHOSPHORIBOSYLAMINOIMIDAZOLE SUCCINOCARBOXAMIDE SYNTHETASE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE PHOSPHORIBOSYLAMINOIMIDAZOLE SYNTHETASE; PROTEIN GART; PROTEIN PAICS; PURINE NUCLEOSIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO DEVELOPMENT; EXON; EYE DEVELOPMENT; GENE DUPLICATION; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; HOMOZYGOSITY; MICROPHTHALMIA; NERVE CELL DIFFERENTIATION; NONHUMAN; PHENOTYPE; PIGMENT CELL; PIGMENTATION; PRIORITY JOURNAL; PURINE SYNTHESIS; ZEBRA FISH;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CARBOXY-LYASES; CELL PROLIFERATION; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; EYE; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GUANOSINE TRIPHOSPHATE; INOSINE MONOPHOSPHATE; MICROPHTHALMOS; MODELS, BIOLOGICAL; MUTATION; PEPTIDE SYNTHASES; PHENOTYPE; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; PIGMENTATION; PIGMENTS, BIOLOGICAL; PURINES; RETINA; S PHASE; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO; VERTEBRATA;

EID: 69049115206     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.038315     Document Type: Article

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