Human formyl peptide receptor 1 (FPR1) c.32C>T SNP is associated with decreased soluble E-selectin levels

Pharmacogenomics

Volumn 10, Issue 6, 2009, Pages 951-959

  Benachour, Hamanou ^a   Zaiou, Mohamed ^a   Herbeth, Bernard ^a   Lambert, Daniel ^a   Lamont, John V ^a,b   Pfister, Michèle ^a   Siest, Gérard ^a   Tiret, Laurence ^a,c   Blankenberg, Stefan ^a,d   Fitzgerald, Peter S ^a,b   Visvikis Siest, Sophie ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b Randox Laboratories Ltd   (United Kingdom)

^c SORBONNE UNIVERSITÉ   (France)

^d UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Adhesion molecules; Formyl peptide receptor; G protein coupled receptor; Inflammation; SNP

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFLAMMATORY AGENT; C REACTIVE PROTEIN; CYTOKINE; CYTOSINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FORMYLPEPTIDE RECEPTOR; INTERCELLULAR ADHESION MOLECULE 1; ORAL CONTRACEPTIVE AGENT; RESTRICTION ENDONUCLEASE; THYMINE;

ADULT; AGE DISTRIBUTION; ALCOHOL CONSUMPTION; AMINO ACID SUBSTITUTION; ARTICLE; BODY MASS; CIGARETTE SMOKING; DRUG USE; FEMALE; FRANCE; GENE AMPLIFICATION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INFLAMMATION; MALE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PROTEIN BLOOD LEVEL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALLELES; ANTHROPOMETRY; BIOLOGICAL MARKERS; COHORT STUDIES; E-SELECTIN; FEMALE; FRANCE; GENE FREQUENCY; GENES, RECESSIVE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOZYGOTE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, FORMYL PEPTIDE; SOLUBILITY;

EID: 69049099151     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.09.29     Document Type: Article

References (42)

1. Prossnitz ER, Ye RD: The N-formyl peptide recepton a model for the study of chemoattractant receptor structure and function. Pharmacol. Ther. 74, 73-102 (1997).
2. Le Y, Hu J, Gong W et al.: Expression of functional formyl peptide receptors by human astrocytoma cell lines. J. Neuroimmunol. 111, 102-108 (2000).
3. Schiffmann E, Showell HV, Corcoran BA, Ward PA, Smith E, Becker EL: The isolation and partial characterization of neutrophil chemotactic factors from Escherichia coli. J. Immunol. 114, 1831-1837 (1975).
4. Le Y, Murphy PM, Wang JM: Formyl-peptide receptors revisited. Trends Immunol. 23, 541-548 (2002).
5. Murphy PM: The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12, 593-633 (1994).
6. Le Y, Yang Y, Cui Y et al.: Receptors for chemotactic formyl peptides as pharmacological targets. Int. Immunopharmacol. 2, 1-13 (2002).
7. Bao L, Gerard NP, Eddy RL Jr, Shows TB, Gerard C: Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. Genomics 13, 437-440 (1992).
8. Murphy PM, Ozçelik T, Kenney RT, Tiffany HL, McDermott D, Francke U: A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family. J. Biol. Chem. 267, 7637-7643 (1992).
9. Ye RD, Cavanagh SL, Quehenberger O, Prossnitz ER, Cochrane CG: Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor. Biochem. Biophys. Res. Commun. 184, 582-589 (1992).
10. Nomura H, Nielsen BW, Matsushima K: Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. Int. Immunol. 5, 1239-1249 (1993).
11. Migeotte I, Communi D, Parmentier M: Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses. Cytokine Growth Factor Rev. 17, 501-519 (2006).
12. Perez HD, Holmes R, Kelly E, McClary J, Andrews WH: Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils. Gene 118, 303-304 (1992).
13. Gao JL, Chen H, Filie JD, Kozak CA, Murphy PM: Differential expansion of the N-formyl peptide receptor gene cluster in human and mouse. Genomics 51, 270-276 (1998).
14. Haviland DL, Borel AC, Fleischer DT, Haviland JC, Wetsel RA: Structure, 5′-flanking sequence, and chromosome location of the human N-formyl peptide receptor gene. A single-copy gene comprised of two exons on chromosome 19q.13.3 that yields two distinct transcripts by alternative polyadenylation. Biochemistry 32, 4168-4174 (1993).
15. Gunji T, Onouchi Y, Nagasawa T et al.: Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese. Biochem. Biophys. Res. Commun. 364, 7-13 (2007).
16. Seifert R, Wenzel-Seifert K: Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis. J. Biol. Chem. 276, 42043-42049 (2001).
17. Jones BE, Miettinen HM, Jesaitis AJ, Mills JS: Mutations of F110 and C126 of the formyl peptide receptor interfere with G-prciiein coupling and chemotaxis. J. Periodoniol. 74, 475-484 (2003).
18. Zhang Y, Syed R, Uygar C et al.: Evaluation of human leukocyte N-formyl peptide receptor (FPR1) SNPs in aggressive periodontitis patients. Genes Immun. 4, 22-29 (2003.
19. Sahagun-Ruiz A, Colla JS, Juhn J, Gao J-L, Murphy PM, McDermott DH: Contrasting evolution of the human leukocyte N-formyl peptide receptor subtypes FPR and FPRL1R. Genes Immun. 2, 335-342 (2001).
20. Gwinn MR, Sharma A, De Nardin E: Single nucleotide polymorphisms of the N-formyl peptide receptor in localized juvenile periodontitis. J. Periodontol. 70, 1194-1201 (1999).
21. Bhattacharya M, Wang J, Ribeiro, FM et al.: Analysis of a missense variant of the human N-formyl peptide receptor that is associated with agonist-independent β-arrestin association and indices of inflammation. Pharmacogenomics 7, 190-199 (2007).
22. Siest G, Visvikis S, Herbeth B et al.: Objectives, design and recruitment of a familial and longitudinal cohort for studying gene-environment interactions in the field of cardiovascular risk: the STANISLAS cohort. Clin. Chem. Lab. Med. 36, 35-42 (1998).
23. Ponthieux A, Herbeth B, Droesch S, Haddy N, Lambert D, Visvikis S: Biological determinants of serum ICAM-1, E-selectin, P-selectin and L-selectin levels in healthy subjects: the Stanislas study. Atherosclerosis 172, 299-308 (2004).
24. Berrahmoune K, Herbeth B, Lamont JV et al.: Association of classical and related inflammatory markers with high-sensitivity C-reactive protein in healthy individuals: results from the Stanislas cohort. Clin. Chem. Lab. Med. 45, 1339-1346 (2007).
25. Miller SA, Dekes DD, Polesky HF: A simple salting-out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16, 1215 (1988).
26. Blann AD, Davis A, Miller JP, McCollum CN: Von Willebrand factor and soluble E-selectin in hyperlipidaemia: relationship to lipids and vascular disease. Am. J. Hematol. 55, 15-23 (1997).
27. Kowalska I, Straczkowski M, Szelachowska M et al.: Circulating E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in men with coronary artery disease assessed by angiography and disturbances of carbohydrate metabolism. Metabolism 51, 733-736 (2002).
28. Sass C, Pallaud C, Zannad F, Visvikis S: Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort. Hum. Genet. 107, 58-61 (2000).
29. Gao JL, Lee EJ, Murphy PM: Impaired antibacterial host defense in mice lacking the N-formyl peptide receptor. J. Exp. Med. 189, 657-662 (1999).
30. 2+, mobilization. J. Biol. Chem. 275, 15758-15764 (2000).
31. Bevilacqua MP, Nelson RM: Selectins. J. Clin. Invest. 91, 379-387 (1993).
32. Carlos TM, Harlan JM: Leukocyte-endothelial adhesion molecules. Blood 84, 2068-2101 (1994).
33. McMeekin SR, Dransfield I, Rossi AG, Haslett C, Walker TR: E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils. Blood 107, 4938-4945 (2006).
34. Ley K, Allietta M, Bullard DC, Morgan S: Importance of E-sdectin for firm leukocyte adhesion in vivo. Circ. Res. 83, 287-294 (1998).
35. Rossi B, Constantin G: Anti-selectin therapy for the treatment of inflammatory diseases. Inflamm. Allergy Drug Targets 7, 85-93 (2008).
36. Fujita T, Fujimoto M, Matsushita T et al.: Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses. Am. J. Pathol. 170, 1649-1658 (2007).
37. Labow MA, Norton CR, Rumberger JM et al.: Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity 1, 709-720 (1994).
38. Ford ES, Galuska DA, Gillespie C, Will JC, Giles WH, Dietz WH: C-reactive protein and body mass index in children: findings from the Third National Health and Nutrition Examination Survey, 1988-1994. J. Pediatr. 138, 486-92 (2001).
39. Roberts WL, Sedrick R, Moulton L, Spencer A, Rifai N: Evaluation of four automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications. Clin. Chem. 46, 461-468 (2000).
40. Roberts WL, Moulton L, Law TC et al.: Evaluation of nine automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications. Part 2. Clin. Chem. 47, 418-425 (2001).
41. Ledue TB, Rifai N: Preanalytic and analytic sources of variations in C-reactive protein measurement: implications for cardiovascular disease risk assessment. Clin. Chem. 49, 1258-1271 (2003).
42. Yeboah J, Klein K, Brosnihan B, Reboussin D, Herrington DM: Effects of hormone therapy on soluble cell adhesion molecules in postmenopausal women with coronary artery disease. Menopause 15, 1060-1064 (2008).