Potential role of α-synuclein and metallothionein in lead-induced inclusion body formation

Toxicological Sciences

Volumn 111, Issue 1, 2009, Pages 100-108

  Zuo, Peijun ^a   Qu, Wei ^a   Cooper, Ryan N ^a   Goyer, Robert A ^a   Diwan, Bhalchandra A ^b   Waalkes, Michael P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

synuclein; Inclusion bodies; Lead; Metallothionein; MT null

Indexed keywords

ALPHA SYNUCLEIN; LEAD; METALLOTHIONEIN;

ANIMAL CELL; ARTICLE; CELL AGGREGATION; CELL INCLUSION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; EMBRYO; IMMUNOPRECIPITATION; LONG TERM EXPOSURE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; TOXICITY TESTING; WESTERN BLOTTING;

ALPHA-SYNUCLEIN; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DNA; IMMUNOHISTOCHEMISTRY; INCLUSION BODIES; LEAD; METALLOTHIONEIN; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

MUS;

EID: 69049097155     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp132     Document Type: Article

References (29)

1. Coon, S., Stark, A., Peterson, E., Gloi, A., Kortsha, G., Pounds, J., Chettle, D., and Gorell, J. (2006). Whole-body lifetime occupational lead exposure and risk of Parkinson's disease. Environ. Health Perspect. 114, 1872-1876.
2. Cookson, M. R. (2005). The biochemistry of Parkinson's disease. Annu. Rev. Biochem. 74, 29-52.
3. Fowler, B. A. (1998). Roles of lead-binding proteins in mediating lead bioavailability. Environ. Health Perspect. 106, 1585-1587.
4. Garvey, J. S. (1984). Metallothionein: Structure/antigenicity and detection/quantitation in normal physiological fluids. Environ. Health Perspect. 54, 117-127.
5. Goering, P. L. (1993). Lead-protein interactions as a basis for lead toxicity. Neurotoxicology 14, 45-60.
6. Goyer, R. A., and Rhyne, B. C. (1973). Pathological effects of lead. Int. Rev. Exp. Pathol. 12, 1-77.
7. Ikebuchi, H., Teshima, R., Suzuki, K., Terao, T., and Yamane, Y. (1986). Stimultaneous induction of Pb-metallothionein-like protein and Zn-thionein in the liver of rats given lead acetate. Biochem. J. 233, 541-546.
8. IARC(International Agency for Research on Cancer). (2006). Inorganic and organic lead compounds. Williams, R., Ed. 2006. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 87, pp. 1-471. WHO Press, Lyon, France.
9. IPCS(International Programme on Chemical Safety). (1995). Inorganic lead. Jenkins, P. G., Ed. 1995. Environmental Health Criteria 165, pp. 1-300. World Health Organization, Geneva, Switzerland.
10. Klaassen, C. D., Liu, J., and Choudhuri, S. (1999). Metallothionein: An intracellular protein to protect against cadmium toxicity. Annu. Rev. Pharmacol. Toxicol. 39, 267-294.
11. Klann, E., and Shelton, K. R. (1989). The effect of lead on the metabolism of a nuclear matrix protein which becomes prominent in lead-induced intranuclear inclusion bodies. J. Biol. Chem. 264 16969-16972.
12. Kondo, Y., Yanagiya, T., Himeno, S., Yamabe, Y., Schwartz, D., Akimoto, M., Lazo, J. S., and Imura, N. (1999). Simian virus 40-transformed metallothionein null cells showed increased sensitivity to cadmium but not to zinc, copper, mercury or nickel. Life Sci. 64, PL145-PL150.
13. Kuhn, W., Winkel, R., Woitalla, D., Meves, S., Przuntek, H., and Müller, T. (1998). High prevalence of parkinsonism after occupational exposure to lead-sulfate batteries. Neurology 50, 1885-1886.
14. Lazo, J. S., Kondo, Y., Dellapiazza, D., Michalska, A. E., Choo, K. H., and Pitt, B. R. (1995). Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J. Biol. Chem. 270, 5506-5510.
15. Liu, J., Cheng, M. L., Yang, Q., Shan, K. R., Shen, J., Zhou, Y., Zhang, X., Dill, A. L., and Waalkes, M. P. (2007). Blood metallothionein transcript as a biomarker for metal sensitivity: Low blood metallothionein transcripts in arsenicosis patients from Guizhou, China. Environ. Health Perspect. 115, 1101-1106.
16. Loghman-Adham, M. (1997). Renal effects of environmental and occupational lead exposure. Environ. Health Perspect. 105, 928-939.
17. McLachlin, J. R., Goyer, R. A., and Cherian, M. G. (1980). Formation of leadinduced inclusion bodies in primary rat kidney epithelial cell cultures: Effect of actinomycin D and cycloheximide. Toxicol. Appl. Pharmacol. 56, 418-431.
18. Nolan, C. V., and Shaikh, Z. A. (1992). Lead nephrotoxicity and associated disorders: Biochemical mechanisms. Toxicology 73, 127-146.
19. Olanow, C. W., and Perl, D. P. (2004). Lewy-body formation is an aggresomerelated process: A hypothesis. Lancet Neurol. 3, 496-503.
20. Qu, W., Diwan, B. A., Liu, J., Goyer, R. A., Dawson, T., Horton, J. L., Cherian, M. G., and Waalkes, M. P. (2002). The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies. Am. J. Pathol. 160, 1047-1056.
21. Semchuck, K. M., Love, E. J., and Lee, R. G. (1993). Parkinson's disease: A test of the multifactorial etiologic hypothesis. Neurology 43, 1173-1180.
22. Tanner, C. M., and Langston, J. W. (1990). Do environmental toxins cause Parkinson's disease? A critical review. Neurology 40, 17-30.
23. Taylor, J. P., Hardy, J., and Fischbeck, K. H. (2002). Toxic proteins in neurodegenerative disease. Science 296, 1991-1995.
24. Toscano, C. D., and Guilarte, T. R. (2005). Lead neurotoxicity: From exposure to molecular effects. Brain Res. Brain Res. Rev. 49 529-554.
25. Waalkes, M. P., Harvey, M. J., and Klaassen, C. D. (1984). Relative in vitro affinity of hepatic metallothionein for metals. Toxicol. Lett. 20, 33-39.
26. Waalkes, M. P., Liu, J., Goyer, R. A., and Diwan, B. A. (2004). Metallothionein-I/II double knockout mice are hypersensitive to lead-induced kidney carcinogenesis: Role of inclusion body formation. Cancer Res. 64, 7766-7772.
27. White, L. D., Cory-Slechta, D. A., Gilbert, M. E., Tiffany-Castiglioni, E., Zawia, N. H., Virgolini, M., Rossi-George, A., Lasley, S. M., Qian, Y. C., and Basha, M. R. (2007). New and evolving concepts in the neurotoxicology of lead. Toxicol. Appl. Pharmacol. 225, 1-27.
28. Wu, J., Basha, M. R., Brock, B., Cox, D. P., Cardozo-Pelaez, F., McPherson, C. A., Harry, J., Rice, D. C., Maloney, B., Chen, D., et al. (2008). Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): Evidence for a developmental origin and environmental link for AD. J. Neurosci. 28, 3-9.
29. Zhou, W., and Freed, C. R. (2004). Tyrosine-to-cysteine modification of human alpha-synuclein enhances protein aggregation and cellular toxicity. J. Biol. Chem. 279, 10128-10135.