Targeting NAD Biosynthesis in Bacterial Pathogens: Structure-Based Development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD

Chemistry and Biology

Volumn 16, Issue 8, 2009, Pages 849-861

  Sorci, Leonardo ^a   Pan, Yongping ^b   Eyobo, Yvonne ^c   Rodionova, Irina ^a   Huang, Nian ^c   Kurnasov, Oleg ^a   Zhong, Shijun ^b   MacKerell Jr , Alexander D ^b   Zhang, Hong ^c   Osterman, Andrei L ^a  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

CHEMBIO; MICROBIO; PROTEINS

Indexed keywords

ANTIINFECTIVE AGENT; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE; NICOTINIC ACID MONONUCLEOTIDE ADENYLYLTRANSFERASE;

ARTICLE; BACILLUS ANTHRACIS; BINDING SITE; BIOLOGY; BIOSYNTHESIS; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; ESCHERICHIA COLI; KINETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; BACILLUS ANTHRACIS; BINDING SITES; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ESCHERICHIA COLI; KINETICS; NAD; NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE; PROTEIN STRUCTURE, TERTIARY;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 69049089756     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2009.07.006     Document Type: Article

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