Identification of a new broad-spectrum CD8+ T cell epitope from over-expressed antigen COX-2 in esophageal carcinoma

Cancer Letters

Volumn 284, Issue 1, 2009, Pages 55-61

  Gao, Yan feng ^a   Sun, Zhan qiang ^a   Qi, Feng ^a   Qi, Yuan ming ^a   Zhai, Ming xia ^a   Lou, Hui ping ^a   Chen, Li xiang ^a   Li, Yong xin ^a   Wang, Xian yuan ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Broad spectrum; Cyclooxygenase 2; Cytotoxic T lymphocyte; Epitope; Esophageal carcinoma

Indexed keywords

ALANYLLEUCYLTYROSYLGLYCYLASPARTYLISOLEUCYLASPARTYLALANYLVALINE; ALANYLVALYLGLUTAMYLLEUCYLTYROSYLPROPYLALANYLLEUCYLLEUCINE; ARGINYLLEUCYLISOLEUCYLLEUCYLISOLEUCYLGLYCYLGLUTAMYLTHREONYLISOLEUCINE; CYCLOOXYGENASE 2; EPITOPE; GAMMA INTERFERON; HLA A2 ANTIGEN; HLA A3 ANTIGEN; INFLUENZA NUCLEAR PROTEIN[265-273]; INFLUENZA NUCLEAR PROTEIN[58-66]; PHENYLALANYLLEUCYLARGINYLASPARAGINYLALANYLISOLEUCYLMETHIONYLSERYLTYROSINE; PHENYLALANYLLEUCYLLYSYLPROPYLTHREONYLPROPYLASPARAGINYLTHREONYLVALINE; POLYPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER IMMUNOTHERAPY; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; EPITOPE MAPPING; ESOPHAGUS CARCINOMA; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOGENICITY; INTERFERON PRODUCTION; PRIORITY JOURNAL; PROTEIN STABILITY;

ANTIGENS, NEOPLASM; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CYCLOOXYGENASE 2; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; ESOPHAGEAL NEOPLASMS; HLA-A ANTIGENS; HUMANS; INTERFERON-GAMMA; OLIGOPEPTIDES;

EID: 69049085528     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.04.009     Document Type: Article

References (31)

1. Wang R.F., and Rosenberg S.A. Human tumor antigens recognized by T lymphocytes: implications for cancer therapy. J. Leukoc. Biol. 60 (1996) 296-309
2. Renkvist N., Castelli C., Robbins P.F., and Parmiani G. A listing of human tumor antigens recognized by T cells. Cancer Immunol. Immunother. 50 (2001) 3-15
3. Jäger E., Nagata Y., Gnjatic S., Wada H., Stockert E., Karbach J., Dunbar P.R., Lee S.Y., Jungbluth A., Jäger D., Arand M., Ritter G., Cerundolo V., Dupont B., Chen Y.T., Old L.J., and Knuth A. Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses. Proc. Natl. Acad. Sci. USA 97 (2000) 4760-4765
4. Miyashita M., Makino H., Katsuta M., Nomura T., Shinji S., Kashiwabara M., Takahashi K., Kudo M., Ishiwata T., Naito Z., and Tajiri T. Cyclo-oxygenase-2 over-expression is associated with human esophageal squamous cell carcinoma. J. Nippon Sch. 73 (2006) 308-313
5. Oyama K., Fujimura T., Ninomiya I., Miyashita T., Kinami S., Fushida S., et al. A COX-2 inhibitor prevents the esophageal inflammation-mataplasia-adenocarcinoma sequence in rats. Carcinogenesis 26 (2005) 565-570
6. Zhou J., Zhao L.Q., Xiong M.M., Wang X.Q., Yang G.R., Qiu Z.L., Wu M., and Liu Z.H. Gene expression profiles at different stages of human esophageal squamous cell carcinoma. World J. Gastroenterol. 9 (2003) 9-15
7. Chen S.R., Luo Y.P., Zhang J.K., Yang W., Zhen Z.C., Chen L.X., and Zhang W. Study on immune function of dendritic cells in patients with esophageal carcinoma. World J. Gastroenterol. 10 (2004) 934-939
8. Zimmermann K.C., Sarbia M., Weber A.A., Borchard F., Gabbert H.E., and Schror K. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res. 59 (1999) 198-204
9. Dubois R.N., Tsujii M., Bishop P., Awad J.A., Makita K., and Lanahan A. Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal cells. Am. J. Physiol. 266 (1994) 822-827
10. Hempel S.L., Monick M.M., and Hunninghake G.W. Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes. J. Clin. Invest. 93 (1994) 391-396
11. Vonderheide R.H., Anderson K.S., Hahn W.C., Butler M.O., Schultze J.L., and Nadler L.M. Characterization of HLA-A*03-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase. Clin. Cancer Res. 7 (2001) 3343-3348
12. Ferenc H. Manipulation of epitope function by modification of peptide structure: a minireview. Biologicals 29 (2001) 197-207
13. Rammensee H., Bachmann J., Emmerich N.P., Bachor O.A., and Stevanović S. SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics 50 (1999) 213-219
14. Guan P., Doytchinova I.A., Zygouri C., and Flower D.R. MHCPred: a server for quantitative prediction of peptide-MHC binding. Nucl. Acids Res. 31 (2003) 3621-3624
15. Nielsen M., Lundegaard C., Lund O., and Kesmir C. The role of the proteasome in generating cytotoxic T cell epitopes: insights obtained from improved predictions of proteasomal cleavage. Immunogenetics 57 (2005) 33-41
16. Vonderheide R.H., Hahn W.C., Schultze J.L., and Nadler L.M. The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes. Immunity 10 (1999) 673-679
17. Wang Y., Han K.J., Pang X.W., Vaughan H.A., Qu W., Dong X.Y., Peng J.R., Zhao H.T., Rui J.A., Leng X.S., Cebon J., Burgess A.W., and Chen W.F. Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. J. Immunol. 169 (2002) 1102-1109
18. Romani N., Reider D., Heuer M., Ebner S., Kämpgen E., Eibl B., Niederwieser D., and Schuler G. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J. Immunol. Methods 196 (1996) 137-151
19. + T-cell response in a northern Chinese population. Tissue Antigen 62 (2003) 285-295
20. Makita M., Hiraki A., Azuma T., Tsuboi A., Oka Y., Sugiyama H., Fujita S., Tanimoto M., Harada M., and Yasukawa M. Antilung cancer effect of WT1-specific cytotoxic T lymphocytes. Clin. Cancer Res. 8 (2002) 2626-2631
21. Fikes J.D., and Sette A. Design of multi-epitope, analogue-based cancer vaccines. Expert Opin. Biol. Ther. 3 (2003) 985-993
22. Xue F., Wang J., Hu P., Ma D., Liu J., Li G., Zhang L., Wu M., Sun G., and Hou H. Identification of spatial genetic boundaries using a multifractal model in human population genetics. Hum. Biol. 77 (2005) 577-617
23. Sette A., and Sidney D. Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism. Immunogenetics 50 (1999) 201-212
24. Cordon-Cardo C., Fuks Z., Drobnjak M., Moreno C., Eisenbach L., and Feldman M. Expression of HLA-A,B,C antigens on primary and metastatic tumor cell populations of human carcinomas. Cancer Res. 51 (1991) 6372-6380
25. Kageshita T., Wang Z., Calorini L., Yoshii A., Kimura T., Ono T., Gattoni-Celli S., and Ferrone S. Selective loss of human leukocyte class I allospecificities and staining of melanoma cells by monoclonal antibodies recognizing monomorphic determinants of class I human leukocyte antigens. Cancer Res. 53 (1993) 3349-3354
26. Garrido F., Ruiz-Cabello F., Cabrera T., Pérez-Villar J.J., López-Botet M., Duggan-Keen M., and Stern P.L. Implications for immunosurveillance of altered HLA class I phenotypes in human tumours. Immunol. Today 18 (1997) 89-95
27. Wang Z., Marincola F.M., Rivoltini L., Parmiani G., and Ferrone S. Selective histocompatibility leukocyte antigen (HLA)-A2 loss caused by aberrant pre-mRNA splicing in 624MEL28 melanoma cells. J. Exp. Med. 190 (1999) 205-215
28. Koopman L.A., Corver W.E., van der Slik A.R., Giphart M.J., and Fleuren G.J. Multiple genetic alterations cause frequent and heterogeneous human histocompatibility leukocyte antigen class I loss in cervical cancer. J. Exp. Med. 191 (2000) 961-976
29. Scardino A., Gross D.A., Alves P., Schultze J.L., Graff-Dubois S., Faure O., Tourdot S., Chouaib S., Nadler L.M., Lemonnier F.A., Vonderheide R.H., Cardoso A.A., and Kosmatopoulos K. HER-2/neu and hTERT cryptic epitopes as novel targets for broad spectrum tumor immunotherapy. J. Immunol. 168 (2002) 5900-5906
30. Schmittel A., Keilholz U., Thiel E., and Scheibenbogen C. Quantification of Tumor-specific T lymphocytes with the ELISPOT assay. J. Immunother. 23 (2000) 289-295
31. Velculescu V.E., Madden S.L., Zhang L., Lash A.E., Yu J., Rago C., Lal A., Wang C.J., Beaudry G.A., Ciriello K.M., Cook B.P., Dufault M.R., Ferguson A.T., Gao Y., He T.C., Hermeking H., Hiraldo S.K., Hwang P.M., Lopez M.A., Luderer H.F., Mathews B., Petroziello J.M., Polyak K., Zawel L., Kinzler K.W., et al. Analysis of human transcriptomes. Nat. Genet. 23 (1999) 387-388