Seizure activity and neurological sequelae in Ugandan children who have survived an episode of cerebral malaria

African Health Sciences

Volumn 9, Issue 2, 2009, Pages 75-81

  Opoka, Robert O ^a   Bangirana, Paul ^a,b   Boivin, Michael J ^c   John, Chandy C ^d   Byarugaba, Justus ^a  

^a MAKERERE UNIVERSITY MEDICAL SCHOOL   (Uganda)

^b KAROLINSKA INSTITUTE   (Sweden)

^c East Lansing   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Cerebral malaria; Children; Neurological deficits; Seizures; Survivors

Indexed keywords

ARTICLE; ATAXIA; ATTENTION DEFICIT DISORDER; BRAIN MALARIA; CHILD; CONTROLLED STUDY; COORDINATION DISORDER; FEMALE; FOLLOW UP; HUMAN; HYPERREFLEXIA; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUROLOGICAL COMPLICATION; NUTRITIONAL STATUS; QUADRIPLEGIA; SEIZURE; SOCIAL STATUS; STATISTICAL ANALYSIS; SURVIVOR; UGANDA; VISUAL IMPAIRMENT; ANALYSIS OF VARIANCE; CASE CONTROL STUDY; CENTRAL NERVOUS SYSTEM DISEASE; DEVELOPMENTAL DISORDER; MALARIA; PRESCHOOL CHILD; PROGNOSIS; PROSPECTIVE STUDY; SOCIOECONOMICS; TREATMENT OUTCOME;

ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CENTRAL NERVOUS SYSTEM DISEASES; CHILD; CHILD, PRESCHOOL; DEVELOPMENTAL DISABILITIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALARIA, CEREBRAL; MALE; PROGNOSIS; PROSPECTIVE STUDIES; SEIZURES; SOCIOECONOMIC FACTORS; TREATMENT OUTCOME;

EID: 68949215570     PISSN: 16806905     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Murphy SC, Breman JG. Gaps in the childhood malaria burden in Africa: cerebral malaria, neurological sequelae, anemia, respiratory distress, hypoglycemia, and complications of pregnancy. The American journal of tropical medicine and hygiene. 2001 Jan-Feb;64(1-2 Suppl):57-67.
2. Mung'Ala-Odera V, Snow RW, Newton CR. The burden of the neurocognitive impairment associated with Plasmodium falciparum malaria in sub-saharan Africa. The American journal of tropical medicine and hygiene. 2004 Aug;71(2 Suppl):64-70.
3. Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V, et al. Indicators of life-threatening malaria in African children. The New England journal of medicine. 1995 May 25;332(21):1399-404.
4. Molyneux ME, Taylor TE, Wirima JJ, Borgstein A. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. The Quarterly journal of medicine. 1989 May;71(265):441-59.
5. Waruiru CM, Newton CR, Forster D, New L, Winstanley P, Mwangi I, et al. Epileptic seizures and malaria in Kenyan children. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1996 Mar-Apr;90(2):152-5.
6. Jaffar S, Van Hensbroek MB, Palmer A, Schneider G, Greenwood B. Predictors of a fatal outcome following childhood cerebral malaria. The American journal of tropical medicine and hygiene. 1997 Jul;57(1):20-4.
7. Brewster DR, Kwiatkowski D, White NJ. Neurological sequelae of cerebral malaria in children. Lancet. 1990 Oct 27;336(8722):1039-43.
8. Bondi FS. The incidence and outcome of neurological abnormalities in childhood cerebral malaria: a long-term follow-up of 62 survivors. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1992 Jan-Feb;86(1):17-9.
9. van Hensbroek MB, Palmer A, Jaffar S, Schneider G, Kwiatkowski D. Residual neurologic sequelae after childhood cerebral malaria. The Journal of pediatrics. 1997 Jul;131(1 Pt 1):125-9.
10. Ngoungou EB, Koko J, Druet-Cabanac M, Assengone-Zeh-Nguema Y, Launay MN, Engohang E, et al. Cerebral malaria and sequelar epilepsy: first matched case-control study in Gabon. Epilepsia. 2006 Dec;47(12):2147-53.
11. Carter JA, Ross AJ, Neville BG, Obiero E, Katana K, Mung'ala-Odera V, et al. Developmental impairments following severe falciparum malaria in children. Trop Med Int Health. 2005 Jan;10(1):3-10.
12. Idro R, Karamagi C, Tumwine J. Immediate outcome and prognostic factors for cerebral malaria among children admitted to Mulago Hospital, Uganda. Annals of tropical paediatrics. 2004 Mar;24(1):17-24.
13. Meremikwu MM, Asindi AA, Ezedinachi E. The pattern of neurological sequelae of childhood cerebral malaria among survivors in Calabar, Nigeria. The Central African journal of medicine. 1997 Aug;43(8):231-4.
14. John CC, Opika-Opoka R, Byarugaba J, Idro R, Boivin MJ. Low levels of RANTES are associated with mortality in children with cerebral malaria. The Journal of infectious diseases. 2006 Sep 15;194(6):837-45.
15. EPI INFO 6. Atlanta, GA: Centers for Disease Control and Prevention 2005.
16. Boivin MJ, Bangirana P, Byarugaba J, Opoka RO, Idro R, Jurek AM, et al. Cognitive impairment after cerebral malaria in children: a prospective study. Pediatrics. 2007 Feb;119(2):e360-6.
17. Newton CR, Krishna S. Severe falciparum malaria in children: current understanding of pathophysiology and supportive treatment. Pharmacology & therapeutics. 1998 Jul;79(1):1-53.
18. Olumese PE, Gbadegesin RA, Adeyemo AA, Brown B, Walker A. Neurological features of cerebral malaria in Nigerian children. Annals of tropical paediatrics. 1999 Dec;19(4):321-5.
19. Crawley J, Smith S, Kirkham F, Muthinji P, Waruiru C, Marsh K. Seizures and status epilepticus in childhood cerebral malaria. Qjm. 1996 Aug;89(8):591-7.
20. Carter JA, Neville BG, White S, Ross AJ, Otieno G, Mturi N, et al. Increased prevalence of epilepsy associated with severe falciparum malaria in children. Epilepsia. 2004 Aug;45(8):978-81.
21. Ngoungou EB, Dulac O, Poudiougou B, Druet-Cabanac M, Dicko A, Mamadou Traore A, et al. Epilepsy as a consequence of cerebral malaria in area in which malaria is endemic in Mali, West Africa. Epilepsia. 2006 May;47(5):873-9.
22. Versteeg AC, Carter JA, Dzombo J, Neville BG, Newton CR. Seizure disorders among relatives of Kenyan children with severe falciparum malaria. Trop Med Int Health. 2003 Jan;8(1):12-6.
23. Idro R, Jenkins NE, Newton CR. Pathogenesis, clinical features, and neurological outcome of cerebral malaria. Lancet neurology. 2005 Dec;4(12):827-40.
24. Crawley J, Waruiru C, Mithwani S, Mwangi I, Watkins W, Ouma D, et al. Effect of phenobarbital on seizure frequency and mortality in childhood cerebral malaria: a randomised, controlled intervention study. Lancet. 2000 Feb 26;355(9205):701-6.
25. Neequaye J, Ofori-Adjei E, Ofori-Adjei D, Renner L. Comparative trial of oral versus intramuscular chloroquine in children with cerebral malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1991 Nov-Dec;85(6):718-22.
26. Carme B, Bouquety JC, Plassart H. Mortality and sequelae due to cerebral malaria in African children in Brazzaville, Congo. The American journal of tropical medicine and hygiene. 1993 Feb;48(2):216-21.
27. Murphy S, English M, Waruiru C, Mwangi I, Amukoye E, Crawley J, et al. An open randomized trial of artemether versus quinine in the treatment of cerebral malaria in African children. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1996 May-Jun;90(3):298-301.
28. Idro R, Carter JA, Fegan G, Neville BG, Newton CR. Risk factors for persisting neurological and cognitive impairments following cerebral malaria. Archives of disease in childhood. 2006 Feb;91(2):142-8.
29. Holding PA, Snow RW. Impact of Plasmodium falciparum malaria on performance and learning: review of the evidence. The American journal of tropical medicine and hygiene. 2001 Jan-Feb;64(1-2 Suppl):68-75.
30. Boivin MJ. Effects of early cerebral malaria on cognitive ability in Senegalese children. J Dev Behav Pediatr. 2002 Oct;23(5):353-64.