An expedient one-pot synthesis of novel 10-substituted 9-aminophenanthrenes

Tetrahedron Letters

Volumn 50, Issue 41, 2009, Pages 5704-5708

  Rochais, Christophe ^a   Yougnia, Rodrigue ^a   Dallemagne, Patrick ^a   Rault, Sylvain ^a  

^a CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

Author keywords

Dieckmann Thorpe; Fused ring system; Phenanthrene; Ring closure; Suzuki Miyaura cross coupling

Indexed keywords

2 CYANOBORONIC ESTER; 9 AMINOPHENANTHRENE DERIVATIVE; BENZONITRILE; BIPHENYL DERIVATIVE; BORONIC ACID DERIVATIVE; CESIUM; ESTER DERIVATIVE; METHYL 2 (2 BROMOPHENYL)ACETATE; PALLADIUM; PHENANTHRENE DERIVATIVE; PHENYLACETIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DIECKMANN REACTION; MICROWAVE IRRADIATION; ONE POT SYNTHESIS; RING CLOSING METATHESIS; SUZUKI REACTION;

EID: 68949194719     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.07.124     Document Type: Article

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24. 3 (1.11 mmol). The mixture was irradiated at 150 °C for 20 to 50 min using a microwave reactor. The reaction mixture was then diluted with EtOAc, filtrated on a small pad of Celite, and concentrated under vacuum. The crude mixture was then purified by column chromatography (DCM/CyHex 7/3) to afford the corresponding phenanthrene.