Liquid high concentration IgG1 antibody formulations by precipitation

Journal of Pharmaceutical Sciences

Volumn 98, Issue 9, 2009, Pages 3043-3057

  Matheus, Susanne ^a,c   Friess, Wolfgang ^b   Schwartz, Daniel ^a   Mahler, Hanns Christian ^a,d  

^a Merck Serono GmbH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Crystallization; Excipients; Precipitation; Protein aggregation; Protein formulation; Stability

Indexed keywords

IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY;

ARTICLE; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; PRECIPITATION; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE;

EID: 68949170343     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21526     Document Type: Article

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