-
1
-
-
0036255131
-
Not your father's planarian: a classic model enters the era of functional genomics
-
Newmark P.A., and Sánchez Alvarado A. Not your father's planarian: a classic model enters the era of functional genomics. Nat Rev Genet 3 (2002) 210-219
-
(2002)
Nat Rev Genet
, vol.3
, pp. 210-219
-
-
Newmark, P.A.1
Sánchez Alvarado, A.2
-
4
-
-
44449113934
-
Cell turnover and adult tissue homeostasis: from humans to planarians
-
Pellettieri J., and Sánchez Alvarado A. Cell turnover and adult tissue homeostasis: from humans to planarians. Annu Rev Genet 41 (2007) 83-105
-
(2007)
Annu Rev Genet
, vol.41
, pp. 83-105
-
-
Pellettieri, J.1
Sánchez Alvarado, A.2
-
5
-
-
37049023074
-
Regenerating the central nervous system: how easy for planarians!
-
Cebrià F. Regenerating the central nervous system: how easy for planarians!. Dev Genes Evol 217 (2007) 733-748
-
(2007)
Dev Genes Evol
, vol.217
, pp. 733-748
-
-
Cebrià, F.1
-
6
-
-
43749083492
-
Brain regeneration from pluripotent stem cells in planarian
-
Agata K., and Umesono Y. Brain regeneration from pluripotent stem cells in planarian. Philos Trans R Soc Lond B Biol Sci 363 (2008) 2071-2078
-
(2008)
Philos Trans R Soc Lond B Biol Sci
, vol.363
, pp. 2071-2078
-
-
Agata, K.1
Umesono, Y.2
-
8
-
-
31044446936
-
Planarian regeneration: its end is its beginning
-
Sánchez Alvarado A. Planarian regeneration: its end is its beginning. Cell 124 (2006) 241-245
-
(2006)
Cell
, vol.124
, pp. 241-245
-
-
Sánchez Alvarado, A.1
-
9
-
-
38549130372
-
Planarians, a tale of stem cells
-
Rossi L., Salvetti A., Batistoni R., Deri P., and Gremigni V. Planarians, a tale of stem cells. Cell Mol Life Sci 65 (2008) 16-23
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 16-23
-
-
Rossi, L.1
Salvetti, A.2
Batistoni, R.3
Deri, P.4
Gremigni, V.5
-
10
-
-
73949102343
-
Planarian regeneration: achievements and future directions after 20 years of research
-
10.1387/ijdb.072414es
-
Salò E., Abril J.F., Adell T., Cebrià F., Eckelt K., Fernandez-Taboada E., Handberg-Thorsager M., Iglesias M., Molina M.D., and Rodríguez-Esteban G. Planarian regeneration: achievements and future directions after 20 years of research. Int J Dev Biol (2008) 10.1387/ijdb.072414es
-
(2008)
Int J Dev Biol
-
-
Salò, E.1
Abril, J.F.2
Adell, T.3
Cebrià, F.4
Eckelt, K.5
Fernandez-Taboada, E.6
Handberg-Thorsager, M.7
Iglesias, M.8
Molina, M.D.9
Rodríguez-Esteban, G.10
-
12
-
-
61949083988
-
Autophagy in freshwater planarians
-
González-Estévez C. Autophagy in freshwater planarians. Methods Enzymol 451 (2008) 439-465
-
(2008)
Methods Enzymol
, vol.451
, pp. 439-465
-
-
González-Estévez, C.1
-
14
-
-
67649419593
-
Regeneration: the origin of cancer or a possible cure?
-
10.1016/j.semcdb.2009.04.005
-
Oviedo N.J., and Beane W.S. Regeneration: the origin of cancer or a possible cure?. Semin Cell Dev Biol (2008) 10.1016/j.semcdb.2009.04.005
-
(2008)
Semin Cell Dev Biol
-
-
Oviedo, N.J.1
Beane, W.S.2
-
15
-
-
0004775523
-
Cellular, molecular and genetic approaches to regeneration and pattern formation in planarians
-
Baguñà J., Saló E., Collet J., Auladell C., and Ribas M. Cellular, molecular and genetic approaches to regeneration and pattern formation in planarians. Fortschr Zool 36 (1988) 65-78
-
(1988)
Fortschr Zool
, vol.36
, pp. 65-78
-
-
Baguñà, J.1
Saló, E.2
Collet, J.3
Auladell, C.4
Ribas, M.5
-
16
-
-
0036557832
-
Regeneration in planarians and other worms: new findings, new tools, and new perspectives
-
Salò E., and Baguñà J. Regeneration in planarians and other worms: new findings, new tools, and new perspectives. J Exp Zool 292 (2002) 528-539
-
(2002)
J Exp Zool
, vol.292
, pp. 528-539
-
-
Salò, E.1
Baguñà, J.2
-
17
-
-
0002792287
-
Further contribution to the taxonomy of the Dugesia lugubris-polychroa group with description of Dugesia mediterranea n.sp. (Tricladida, Paludicola)
-
Benazzi M., Banguñà J., Ballester R., Puccinelli I., and Del Papa R. Further contribution to the taxonomy of the Dugesia lugubris-polychroa group with description of Dugesia mediterranea n.sp. (Tricladida, Paludicola). Boll Zool 42 (1975) 81-89
-
(1975)
Boll Zool
, vol.42
, pp. 81-89
-
-
Benazzi, M.1
Banguñà, J.2
Ballester, R.3
Puccinelli, I.4
Del Papa, R.5
-
18
-
-
0036923338
-
The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration
-
Sánchez Alvarado A., Newmark P.A., Robb S.M., and Juste R. The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration. Development 129 (2002) 5659-5665
-
(2002)
Development
, vol.129
, pp. 5659-5665
-
-
Sánchez Alvarado, A.1
Newmark, P.A.2
Robb, S.M.3
Juste, R.4
-
19
-
-
0038610837
-
Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs
-
Mineta K., Nakazawa M., Cebrià F., Ikeo K., Agata K., and Gojobori T. Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs. Proc Natl Acad Sci USA 100 (2003) 7666-7671
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 7666-7671
-
-
Mineta, K.1
Nakazawa, M.2
Cebrià, F.3
Ikeo, K.4
Agata, K.5
Gojobori, T.6
-
20
-
-
29444436838
-
The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: analysis of ESTs from the hermaphroditic strain
-
Zayas R.M., Hernandez A., Habermann B., Wang Y., Stary J.M., and Newmark P.A. The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: analysis of ESTs from the hermaphroditic strain. Proc Natl Acad Sci USA 102 (2005) 18491-18496
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 18491-18496
-
-
Zayas, R.M.1
Hernandez, A.2
Habermann, B.3
Wang, Y.4
Stary, J.M.5
Newmark, P.A.6
-
21
-
-
38049057159
-
MAKER: an easy-to-use annotation pipeline designed for emerging model organism genomes
-
Cantarel B.L., Korf I., Robb S.M., Parra G., Ross E., Moore B., Holt C., Sánchez Alvarado A., and Yandell M. MAKER: an easy-to-use annotation pipeline designed for emerging model organism genomes. Genome Res 18 (2008) 188-196
-
(2008)
Genome Res
, vol.18
, pp. 188-196
-
-
Cantarel, B.L.1
Korf, I.2
Robb, S.M.3
Parra, G.4
Ross, E.5
Moore, B.6
Holt, C.7
Sánchez Alvarado, A.8
Yandell, M.9
-
23
-
-
0030784551
-
A planarian orthopedia homolog is specifically expressed in the branch region of both the mature and regenerating brain
-
Umesono Y., Watanabe K., and Agata K. A planarian orthopedia homolog is specifically expressed in the branch region of both the mature and regenerating brain. Dev Growth Differ 39 (1997) 723-727
-
(1997)
Dev Growth Differ
, vol.39
, pp. 723-727
-
-
Umesono, Y.1
Watanabe, K.2
Agata, K.3
-
24
-
-
59649084941
-
Formaldehyde-based whole-mount in situ hybridization method for planarians
-
Pearson B.J., Eisenhoffer G.T., Gurley K.A., Rink J.C., Miller D.E., and Sánchez Alvarado A. Formaldehyde-based whole-mount in situ hybridization method for planarians. Dev Dyn 238 (2009) 443-450
-
(2009)
Dev Dyn
, vol.238
, pp. 443-450
-
-
Pearson, B.J.1
Eisenhoffer, G.T.2
Gurley, K.A.3
Rink, J.C.4
Miller, D.E.5
Sánchez Alvarado, A.6
-
25
-
-
0342369613
-
Bromodeoxyuridine specifically labels the regenerative stem cells of planarians
-
Newmark P.A., and Sánchez Alvarado A. Bromodeoxyuridine specifically labels the regenerative stem cells of planarians. Dev Biol 220 (2000) 142-153
-
(2000)
Dev Biol
, vol.220
, pp. 142-153
-
-
Newmark, P.A.1
Sánchez Alvarado, A.2
-
26
-
-
33745816717
-
Isolation of planarian X-ray-sensitive stem cells by fluorescence-activated cell sorting
-
For many years, semi-pure enriched fractions of neoblasts from dissociated planarians could only be obtained by density gradient centrifugation or filtration through small-pore nylon meshes. In an important technical achievement, Hayashi and colleagues developed a fluorescence activated cell sorting (FACS) protocol to yield highly pure fractions of living stem cells by comparing single cell suspensions from irradiated and unirradiated animals. This methodology has quickly become a standard analytical tool.
-
Hayashi T., Asami M., Higuchi S., Shibata N., and Agata K. Isolation of planarian X-ray-sensitive stem cells by fluorescence-activated cell sorting. Dev Growth Differ 48 (2006) 371-380. For many years, semi-pure enriched fractions of neoblasts from dissociated planarians could only be obtained by density gradient centrifugation or filtration through small-pore nylon meshes. In an important technical achievement, Hayashi and colleagues developed a fluorescence activated cell sorting (FACS) protocol to yield highly pure fractions of living stem cells by comparing single cell suspensions from irradiated and unirradiated animals. This methodology has quickly become a standard analytical tool.
-
(2006)
Dev Growth Differ
, vol.48
, pp. 371-380
-
-
Hayashi, T.1
Asami, M.2
Higuchi, S.3
Shibata, N.4
Agata, K.5
-
27
-
-
66149123728
-
Flow cytometry methods for the study of cell-cycle parameters of planarian stem cells
-
Kang H., and Alvarado A.S. Flow cytometry methods for the study of cell-cycle parameters of planarian stem cells. Dev Dyn 238 (2009) 1111-1117
-
(2009)
Dev Dyn
, vol.238
, pp. 1111-1117
-
-
Kang, H.1
Alvarado, A.S.2
-
28
-
-
19544373776
-
Multicellularity, stem cells, and the neoblasts of the planarian Schmidtea mediterranea
-
Sánchez Alvarado A., and Kang H. Multicellularity, stem cells, and the neoblasts of the planarian Schmidtea mediterranea. Exp Cell Res 306 (2005) 299-308
-
(2005)
Exp Cell Res
, vol.306
, pp. 299-308
-
-
Sánchez Alvarado, A.1
Kang, H.2
-
29
-
-
34447317567
-
Stem cells and the Planarian Schmidtea mediterranea
-
Sánchez Alvarado A. Stem cells and the Planarian Schmidtea mediterranea. C R Biol 330 (2007) 498-503
-
(2007)
C R Biol
, vol.330
, pp. 498-503
-
-
Sánchez Alvarado, A.1
-
30
-
-
0033608994
-
Double-stranded RNA specifically disrupts gene expression during planarian regeneration
-
Sánchez Alvarado A., and Newmark P.A. Double-stranded RNA specifically disrupts gene expression during planarian regeneration. Proc Natl Acad Sci USA 96 (1999) 5049-5054
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 5049-5054
-
-
Sánchez Alvarado, A.1
Newmark, P.A.2
-
31
-
-
0141706425
-
Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians
-
Newmark P.A., Reddien P.W., Cebrià F., and Sánchez Alvarado A. Ingestion of bacterially expressed double-stranded RNA inhibits gene expression in planarians. Proc Natl Acad Sci USA 100 Suppl. 1 (2003) 11861-11865
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.SUPPL. 1
, pp. 11861-11865
-
-
Newmark, P.A.1
Reddien, P.W.2
Cebrià, F.3
Sánchez Alvarado, A.4
-
32
-
-
17844395204
-
Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria
-
The first large-scale RNAi screen in planarians. 240 genes from a variety of functional categories (e.g. translational regulators, transcriptional regulators, signal transduction pathway components, etc.) yielded phenotypes indicating a role in regeneration, patterning, neoblast proliferation, and/or homeostatic tissue renewal.
-
Reddien P.W., Bermange A.L., Murfitt K.J., Jennings J.R., and Sánchez Alvarado A. Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Dev Cell 8 (2005) 635-649. The first large-scale RNAi screen in planarians. 240 genes from a variety of functional categories (e.g. translational regulators, transcriptional regulators, signal transduction pathway components, etc.) yielded phenotypes indicating a role in regeneration, patterning, neoblast proliferation, and/or homeostatic tissue renewal.
-
(2005)
Dev Cell
, vol.8
, pp. 635-649
-
-
Reddien, P.W.1
Bermange, A.L.2
Murfitt, K.J.3
Jennings, J.R.4
Sánchez Alvarado, A.5
-
33
-
-
0038071491
-
A simple 'soaking method' for RNA interference in the planarian Dugesia japonica
-
Orii H., Mochii M., and Watanabe K. A simple 'soaking method' for RNA interference in the planarian Dugesia japonica. Dev Genes Evol 213 (2003) 138-141
-
(2003)
Dev Genes Evol
, vol.213
, pp. 138-141
-
-
Orii, H.1
Mochii, M.2
Watanabe, K.3
-
34
-
-
38349179867
-
Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis
-
The authors identified Smed-β-catenin-1 as essential for proper regeneration of posterior structures. β-catenin(RNAi) and dishevelled(RNAi) animals regenerate caudal heads, rather than tails. Smed-APC(RNAi) animals display a reciprocal phenotype, regenerating anterior tails, demonstrating that upregulation of β-catenin may be sufficient for posteriorization. The authors also analyzed the expression of over 30 planarian Wnt pathway genes.
-
Gurley K.A., Rink J.C., and Sánchez Alvarado A. Beta-catenin defines head versus tail identity during planarian regeneration and homeostasis. Science 319 (2008) 323-327. The authors identified Smed-β-catenin-1 as essential for proper regeneration of posterior structures. β-catenin(RNAi) and dishevelled(RNAi) animals regenerate caudal heads, rather than tails. Smed-APC(RNAi) animals display a reciprocal phenotype, regenerating anterior tails, demonstrating that upregulation of β-catenin may be sufficient for posteriorization. The authors also analyzed the expression of over 30 planarian Wnt pathway genes.
-
(2008)
Science
, vol.319
, pp. 323-327
-
-
Gurley, K.A.1
Rink, J.C.2
Sánchez Alvarado, A.3
-
35
-
-
38349150677
-
Smed-betacatenin-1 is required for anteroposterior blastema polarity in planarian regeneration
-
The authors showed that Smed-β-catenin-1 is required for posteriorization in intact and regenerating animals; in β-catenin(RNAi) animals, ectopic heads form even in response to small lateral incisions. The authors also identified five Wnt genes expressed in specific regions along the anteroposterior axis.
-
Petersen C.P., and Reddien P.W. Smed-betacatenin-1 is required for anteroposterior blastema polarity in planarian regeneration. Science 319 (2008) 327-330. The authors showed that Smed-β-catenin-1 is required for posteriorization in intact and regenerating animals; in β-catenin(RNAi) animals, ectopic heads form even in response to small lateral incisions. The authors also identified five Wnt genes expressed in specific regions along the anteroposterior axis.
-
(2008)
Science
, vol.319
, pp. 327-330
-
-
Petersen, C.P.1
Reddien, P.W.2
-
36
-
-
0043035495
-
Proceedings of the American Society of Zoologists: Polarity and axial heteromorphosis
-
Morgan T.H. Proceedings of the American Society of Zoologists: Polarity and axial heteromorphosis. Am. Nat. 38 (1904) 502-505
-
(1904)
Am. Nat.
, vol.38
, pp. 502-505
-
-
Morgan, T.H.1
-
37
-
-
84979185937
-
'Polarity' considered as a phenomenon of gradation of materials
-
Morgan T.H. 'Polarity' considered as a phenomenon of gradation of materials. J. Exp. Zool. 2 (1905) 495-506
-
(1905)
J. Exp. Zool.
, vol.2
, pp. 495-506
-
-
Morgan, T.H.1
-
38
-
-
8444251784
-
The Wnt signaling pathway in development and disease
-
Logan C.Y., and Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20 (2004) 781-810
-
(2004)
Annu Rev Cell Dev Biol
, vol.20
, pp. 781-810
-
-
Logan, C.Y.1
Nusse, R.2
-
39
-
-
28944448921
-
Molecular genetics of axis formation in zebrafish
-
Schier A.F., and Talbot W.S. Molecular genetics of axis formation in zebrafish. Annu Rev Genet 39 (2005) 561-613
-
(2005)
Annu Rev Genet
, vol.39
, pp. 561-613
-
-
Schier, A.F.1
Talbot, W.S.2
-
40
-
-
33745896797
-
Wnt/beta-catenin signaling and body plan formation in mouse embryos
-
Marikawa Y. Wnt/beta-catenin signaling and body plan formation in mouse embryos. Semin Cell Dev Biol 17 (2006) 175-184
-
(2006)
Semin Cell Dev Biol
, vol.17
, pp. 175-184
-
-
Marikawa, Y.1
-
41
-
-
53449100540
-
The long and the short of Wnt signaling in C. elegans
-
Hardin J., and King R.S. The long and the short of Wnt signaling in C. elegans. Curr Opin Genet Dev 18 (2008) 362-367
-
(2008)
Curr Opin Genet Dev
, vol.18
, pp. 362-367
-
-
Hardin, J.1
King, R.S.2
-
42
-
-
43049139880
-
Silencing of Smed-betacatenin1 generates radial-like hypercephalized planarians
-
•], a third example of β-catenin's posteriorizing role. The authors found that over a longer time course, some β-catenin(RNAi) regenerates become 'hypercephalized,' a phenotype that the authors interpret as 'radial-like.'
-
•], a third example of β-catenin's posteriorizing role. The authors found that over a longer time course, some β-catenin(RNAi) regenerates become 'hypercephalized,' a phenotype that the authors interpret as 'radial-like.'
-
(2008)
Development
, vol.135
, pp. 1215-1221
-
-
Iglesias, M.1
Gomez-Skarmeta, J.L.2
Saló, E.3
Adell, T.4
-
43
-
-
66149158546
-
Smed-Evi/Wntless is required for {beta}-catenin-dependent and -independent processes during planarian regeneration
-
These authors observed anteriorization similar to the β-catenin(RNAi) phenotype by knocking down the gene encoding SMED-EVI/WNTLESS, which is required for Wnt secretion in other organisms. WntP-1 and Wnt11-2 were identified as putative posterior organizers.
-
Adell T., Saló E., Boutros M., and Bartscherer K. Smed-Evi/Wntless is required for {beta}-catenin-dependent and -independent processes during planarian regeneration. Development 136 (2009) 905-910. These authors observed anteriorization similar to the β-catenin(RNAi) phenotype by knocking down the gene encoding SMED-EVI/WNTLESS, which is required for Wnt secretion in other organisms. WntP-1 and Wnt11-2 were identified as putative posterior organizers.
-
(2009)
Development
, vol.136
, pp. 905-910
-
-
Adell, T.1
Saló, E.2
Boutros, M.3
Bartscherer, K.4
-
44
-
-
34249893688
-
Wnt signaling is required for antero-posterior patterning of the planarian brain
-
Kobayashi C., Saito Y., Ogawa K., and Agata K. Wnt signaling is required for antero-posterior patterning of the planarian brain. Dev Biol 306 (2007) 714-724
-
(2007)
Dev Biol
, vol.306
, pp. 714-724
-
-
Kobayashi, C.1
Saito, Y.2
Ogawa, K.3
Agata, K.4
-
45
-
-
33845423849
-
Wnt/beta-catenin signaling regulates vertebrate limb regeneration
-
Kawakami Y., Rodriguez Esteban C., Raya M., Kawakami H., Marti M., Dubova I., and Izpisua Belmonte J.C. Wnt/beta-catenin signaling regulates vertebrate limb regeneration. Genes Dev 20 (2006) 3232-3237
-
(2006)
Genes Dev
, vol.20
, pp. 3232-3237
-
-
Kawakami, Y.1
Rodriguez Esteban, C.2
Raya, M.3
Kawakami, H.4
Marti, M.5
Dubova, I.6
Izpisua Belmonte, J.C.7
-
46
-
-
33847177201
-
Distinct Wnt signaling pathways have opposing roles in appendage regeneration
-
Stoick-Cooper C.L., Weidinger G., Riehle K.J., Hubbert C., Major M.B., Fausto N., and Moon R.T. Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development 134 (2007) 479-489
-
(2007)
Development
, vol.134
, pp. 479-489
-
-
Stoick-Cooper, C.L.1
Weidinger, G.2
Riehle, K.J.3
Hubbert, C.4
Major, M.B.5
Fausto, N.6
Moon, R.T.7
-
47
-
-
34249292278
-
Wnt/beta-catenin signaling has an essential role in the initiation of limb regeneration
-
Yokoyama H., Ogino H., Stoick-Cooper C.L., Grainger R.M., and Moon R.T. Wnt/beta-catenin signaling has an essential role in the initiation of limb regeneration. Dev Biol 306 (2007) 170-178
-
(2007)
Dev Biol
, vol.306
, pp. 170-178
-
-
Yokoyama, H.1
Ogino, H.2
Stoick-Cooper, C.L.3
Grainger, R.M.4
Moon, R.T.5
-
48
-
-
41149142238
-
Requirement for Wnt and FGF signaling in Xenopus tadpole tail regeneration
-
Lin G., and Slack J.M. Requirement for Wnt and FGF signaling in Xenopus tadpole tail regeneration. Dev Biol 316 (2008) 323-335
-
(2008)
Dev Biol
, vol.316
, pp. 323-335
-
-
Lin, G.1
Slack, J.M.2
-
49
-
-
38849108654
-
Heads or tails: can Wnt tell which one is up?
-
Tanaka E.M., and Weidinger G. Heads or tails: can Wnt tell which one is up?. Nat Cell Biol 10 (2008) 122-124
-
(2008)
Nat Cell Biol
, vol.10
, pp. 122-124
-
-
Tanaka, E.M.1
Weidinger, G.2
-
50
-
-
59849089164
-
Beta-catenin and axis formation in planarians
-
Meinhardt H. Beta-catenin and axis formation in planarians. Bioessays 31 (2009) 5-9
-
(2009)
Bioessays
, vol.31
, pp. 5-9
-
-
Meinhardt, H.1
-
51
-
-
67349110546
-
Wnt signaling in cnidarians
-
Holstein T.W. Wnt signaling in cnidarians. Methods Mol Biol 469 (2008) 47-54
-
(2008)
Methods Mol Biol
, vol.469
, pp. 47-54
-
-
Holstein, T.W.1
-
52
-
-
66949173166
-
Multiple Wnts are involved in Hydra organizer formation and regeneration
-
Lengfeld T., Watanabe H., Simakov O., Lindgens D., Gee L., Law L., Schmidt H.A., Ozbek S., Bode H., and Holstein T.W. Multiple Wnts are involved in Hydra organizer formation and regeneration. Dev Biol 330 (2009) 186-199
-
(2009)
Dev Biol
, vol.330
, pp. 186-199
-
-
Lengfeld, T.1
Watanabe, H.2
Simakov, O.3
Lindgens, D.4
Gee, L.5
Law, L.6
Schmidt, H.A.7
Ozbek, S.8
Bode, H.9
Holstein, T.W.10
-
53
-
-
28844484051
-
The evolution of metazoan axial properties
-
Martindale M.Q. The evolution of metazoan axial properties. Nat Rev Genet 6 (2005) 917-927
-
(2005)
Nat Rev Genet
, vol.6
, pp. 917-927
-
-
Martindale, M.Q.1
-
54
-
-
27744445136
-
Characterization of innexin gene expression and functional roles of gap-junctional communication in planarian regeneration
-
Nogi T., and Levin M. Characterization of innexin gene expression and functional roles of gap-junctional communication in planarian regeneration. Dev Biol 287 (2005) 314-335
-
(2005)
Dev Biol
, vol.287
, pp. 314-335
-
-
Nogi, T.1
Levin, M.2
-
55
-
-
0031790406
-
Platyhelminthes have a hox code differentially activated during regeneration, with genes closely related to those of spiralian protostomes
-
Bayascas J.R., Castillo E., and Saló E. Platyhelminthes have a hox code differentially activated during regeneration, with genes closely related to those of spiralian protostomes. Dev Genes Evol 208 (1998) 467-473
-
(1998)
Dev Genes Evol
, vol.208
, pp. 467-473
-
-
Bayascas, J.R.1
Castillo, E.2
Saló, E.3
-
56
-
-
0033564127
-
The planarian HOM/HOX homeobox genes (Plox) expressed along the anteroposterior axis
-
Orii H., Kato K., Umesono Y., Sakurai T., Agata K., and Watanabe K. The planarian HOM/HOX homeobox genes (Plox) expressed along the anteroposterior axis. Dev Biol 210 (1999) 456-468
-
(1999)
Dev Biol
, vol.210
, pp. 456-468
-
-
Orii, H.1
Kato, K.2
Umesono, Y.3
Sakurai, T.4
Agata, K.5
Watanabe, K.6
-
57
-
-
0035029343
-
Position-specific and non-colinear expression of the planarian posterior (Abdominal-B-like) gene
-
Nogi T., and Watanabe K. Position-specific and non-colinear expression of the planarian posterior (Abdominal-B-like) gene. Dev Growth Differ 43 (2001) 177-184
-
(2001)
Dev Growth Differ
, vol.43
, pp. 177-184
-
-
Nogi, T.1
Watanabe, K.2
-
58
-
-
8444237836
-
Dorsal-ventral patterning and neural induction in Xenopus embryos
-
De Robertis E.M., and Kuroda H. Dorsal-ventral patterning and neural induction in Xenopus embryos. Annu Rev Cell Dev Biol 20 (2004) 285-308
-
(2004)
Annu Rev Cell Dev Biol
, vol.20
, pp. 285-308
-
-
De Robertis, E.M.1
Kuroda, H.2
-
59
-
-
0032235681
-
Molecular cloning of bone morphogenetic protein (BMP) gene from the planarian Dugesia japonica
-
Orii H., Kato K., Agata K., and Watanabe K. Molecular cloning of bone morphogenetic protein (BMP) gene from the planarian Dugesia japonica. Zool Sci 15 (1998) 871-877
-
(1998)
Zool Sci
, vol.15
, pp. 871-877
-
-
Orii, H.1
Kato, K.2
Agata, K.3
Watanabe, K.4
-
60
-
-
34248324376
-
Bone morphogenetic protein is required for dorso-ventral patterning in the planarian Dugesia japonica
-
Orii H., and Watanabe K. Bone morphogenetic protein is required for dorso-ventral patterning in the planarian Dugesia japonica. Dev Growth Differ 49 (2007) 345-349
-
(2007)
Dev Growth Differ
, vol.49
, pp. 345-349
-
-
Orii, H.1
Watanabe, K.2
-
61
-
-
37249048471
-
BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration
-
The authors analyzed the function of Smed-bmp4-1, Smed-smad4-1, and smedolloid-1, reporting both ventralization and midline patterning phenotypes. These included the appearance of a ciliated dorsal epidermis accompanied by dorsal duplication of ventral nerve cords; some animals even swim on their formerly dorsal surfaces (functional ventralization). A role for BMP signaling in medial-lateral patterning was indicated by duplication of photoreceptors and defects in visual axon regeneration at the midline, the inability of lateral regenerates to produce blastemas or re-express lateral margin markers, and indented or absent anterior and posterior blastemas.
-
Reddien P.W., Bermange A.L., Kicza A.M., and Sánchez Alvarado A. BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration. Development 134 (2007) 4043-4051. The authors analyzed the function of Smed-bmp4-1, Smed-smad4-1, and smedolloid-1, reporting both ventralization and midline patterning phenotypes. These included the appearance of a ciliated dorsal epidermis accompanied by dorsal duplication of ventral nerve cords; some animals even swim on their formerly dorsal surfaces (functional ventralization). A role for BMP signaling in medial-lateral patterning was indicated by duplication of photoreceptors and defects in visual axon regeneration at the midline, the inability of lateral regenerates to produce blastemas or re-express lateral margin markers, and indented or absent anterior and posterior blastemas.
-
(2007)
Development
, vol.134
, pp. 4043-4051
-
-
Reddien, P.W.1
Bermange, A.L.2
Kicza, A.M.3
Sánchez Alvarado, A.4
-
62
-
-
35348848366
-
The BMP pathway is essential for re-specification and maintenance of the dorsoventral axis in regenerating and intact planarians
-
Analyzing the roles of Smed-BMP and Smed-Smad1, the authors reported disruption of dorsal-ventral patterning (dorsal duplication of cephalic ganglia and nerve cords, ectopic expression of ventral markers dorsally), as well as expansion of the dorsal midline, duplication of photoreceptors, and defects in blastema growth.
-
Molina M.D., Salò E., and Cebrià F. The BMP pathway is essential for re-specification and maintenance of the dorsoventral axis in regenerating and intact planarians. Dev Biol 311 (2007) 79-94. Analyzing the roles of Smed-BMP and Smed-Smad1, the authors reported disruption of dorsal-ventral patterning (dorsal duplication of cephalic ganglia and nerve cords, ectopic expression of ventral markers dorsally), as well as expansion of the dorsal midline, duplication of photoreceptors, and defects in blastema growth.
-
(2007)
Dev Biol
, vol.311
, pp. 79-94
-
-
Molina, M.D.1
Salò, E.2
Cebrià, F.3
-
63
-
-
11144324462
-
Roof plate-dependent patterning of the vertebrate dorsal central nervous system
-
Chizhikov V.V., and Millen K.J. Roof plate-dependent patterning of the vertebrate dorsal central nervous system. Dev Biol 277 (2005) 287-295
-
(2005)
Dev Biol
, vol.277
, pp. 287-295
-
-
Chizhikov, V.V.1
Millen, K.J.2
-
64
-
-
39249085586
-
Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish
-
Monteiro R., van Dinther M., Bakkers J., Wilkinson R., Patient R., ten Dijke P., and Mummery C. Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Dev Biol 315 (2008) 55-71
-
(2008)
Dev Biol
, vol.315
, pp. 55-71
-
-
Monteiro, R.1
van Dinther, M.2
Bakkers, J.3
Wilkinson, R.4
Patient, R.5
ten Dijke, P.6
Mummery, C.7
-
65
-
-
21044450377
-
Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance
-
Charron F., and Tessier-Lavigne M. Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance. Development 132 (2005) 2251-2262
-
(2005)
Development
, vol.132
, pp. 2251-2262
-
-
Charron, F.1
Tessier-Lavigne, M.2
-
66
-
-
58749091076
-
Two msh/msx-related genes, Djmsh1 and Djmsh2, contribute to the early blastema growth during planarian head regeneration
-
Mannini L., Deri P., Gremigni V., Rossi L., Salvetti A., and Batistoni R. Two msh/msx-related genes, Djmsh1 and Djmsh2, contribute to the early blastema growth during planarian head regeneration. Int J Dev Biol 52 (2008) 943-952
-
(2008)
Int J Dev Biol
, vol.52
, pp. 943-952
-
-
Mannini, L.1
Deri, P.2
Gremigni, V.3
Rossi, L.4
Salvetti, A.5
Batistoni, R.6
-
67
-
-
36549041410
-
Initiation of limb regeneration: the critical steps for regenerative capacity
-
Yokoyama H. Initiation of limb regeneration: the critical steps for regenerative capacity. Dev Growth Differ 50 (2008) 13-22
-
(2008)
Dev Growth Differ
, vol.50
, pp. 13-22
-
-
Yokoyama, H.1
-
68
-
-
0042196121
-
Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate
-
Beck C.W., Christen B., and Slack J.M. Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate. Dev Cell 5 (2003) 429-439
-
(2003)
Dev Cell
, vol.5
, pp. 429-439
-
-
Beck, C.W.1
Christen, B.2
Slack, J.M.3
-
69
-
-
33748848292
-
Temporal requirement for bone morphogenetic proteins in regeneration of the tail and limb of Xenopus tadpoles
-
Beck C.W., Christen B., Barker D., and Slack J.M. Temporal requirement for bone morphogenetic proteins in regeneration of the tail and limb of Xenopus tadpoles. Mech Dev 123 (2006) 674-688
-
(2006)
Mech Dev
, vol.123
, pp. 674-688
-
-
Beck, C.W.1
Christen, B.2
Barker, D.3
Slack, J.M.4
-
70
-
-
0242550694
-
Digit regeneration is regulated by Msx1 and BMP4 in fetal mice
-
Han M., Yang X., Farrington J.E., and Muneoka K. Digit regeneration is regulated by Msx1 and BMP4 in fetal mice. Development 130 (2003) 5123-5132
-
(2003)
Development
, vol.130
, pp. 5123-5132
-
-
Han, M.1
Yang, X.2
Farrington, J.E.3
Muneoka, K.4
-
71
-
-
38049169027
-
BMP signaling mediates stem/progenitor cell-induced retina regeneration
-
Haynes T., Gutierrez C., Aycinena J.C., Tsonis P.A., and Del Rio-Tsonis K. BMP signaling mediates stem/progenitor cell-induced retina regeneration. Proc Natl Acad Sci USA 104 (2007) 20380-20385
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 20380-20385
-
-
Haynes, T.1
Gutierrez, C.2
Aycinena, J.C.3
Tsonis, P.A.4
Del Rio-Tsonis, K.5
-
72
-
-
33750984806
-
Inhibition of BMP signaling during zebrafish fin regeneration disrupts fin growth and scleroblasts differentiation and function
-
Smith A., Avaron F., Guay D., Padhi B.K., and Akimenko M.A. Inhibition of BMP signaling during zebrafish fin regeneration disrupts fin growth and scleroblasts differentiation and function. Dev Biol 299 (2006) 438-454
-
(2006)
Dev Biol
, vol.299
, pp. 438-454
-
-
Smith, A.1
Avaron, F.2
Guay, D.3
Padhi, B.K.4
Akimenko, M.A.5
-
73
-
-
84979383223
-
The dynamics of wound closure and its role in the programming of planarian regeneration. I. Blastema emergence
-
Chandebois R. The dynamics of wound closure and its role in the programming of planarian regeneration. I. Blastema emergence. Dev Growth Differ 21 (1979) 195-204
-
(1979)
Dev Growth Differ
, vol.21
, pp. 195-204
-
-
Chandebois, R.1
-
74
-
-
0032995981
-
The role of dorsoventral interaction in the onset of planarian regeneration
-
Kato K., Orii H., Watanabe K., and Agata K. The role of dorsoventral interaction in the onset of planarian regeneration. Development 126 (1999) 1031-1040
-
(1999)
Development
, vol.126
, pp. 1031-1040
-
-
Kato, K.1
Orii, H.2
Watanabe, K.3
Agata, K.4
-
75
-
-
0035337989
-
Dorsal and ventral positional cues required for the onset of planarian regeneration may reside in differentiated cells
-
Kato K., Orii H., Watanabe K., and Agata K. Dorsal and ventral positional cues required for the onset of planarian regeneration may reside in differentiated cells. Dev Biol 233 (2001) 109-121
-
(2001)
Dev Biol
, vol.233
, pp. 109-121
-
-
Kato, K.1
Orii, H.2
Watanabe, K.3
Agata, K.4
-
76
-
-
61349172450
-
Expression pattern of the expanded noggin gene family in the planarian Schmidtea mediterranea
-
Dolores Molina M.A., Salò E., and Cebrià F. Expression pattern of the expanded noggin gene family in the planarian Schmidtea mediterranea. Gene Expr Patterns 9 (2009) 246-253
-
(2009)
Gene Expr Patterns
, vol.9
, pp. 246-253
-
-
Dolores Molina, M.A.1
Salò, E.2
Cebrià, F.3
-
77
-
-
36049017660
-
Models of biological pattern formation: from elementary steps to the organization of embryonic axes
-
Meinhardt H. Models of biological pattern formation: from elementary steps to the organization of embryonic axes. Curr Top Dev Biol 81 (2008) 1-63
-
(2008)
Curr Top Dev Biol
, vol.81
, pp. 1-63
-
-
Meinhardt, H.1
-
78
-
-
58149216052
-
Signaling cross-talk between TGF-beta/BMP and other pathways
-
Guo X., and Wang X.F. Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res 19 (2009) 71-88
-
(2009)
Cell Res
, vol.19
, pp. 71-88
-
-
Guo, X.1
Wang, X.F.2
-
79
-
-
0036389852
-
Induction of a noggin-like gene by ectopic DV interaction during planarian regeneration
-
Ogawa K., Ishihara S., Saito Y., Mineta K., Nakazawa M., Ikeo K., Gojobori T., Watanabe K., and Agata K. Induction of a noggin-like gene by ectopic DV interaction during planarian regeneration. Dev Biol 250 (2002) 59-70
-
(2002)
Dev Biol
, vol.250
, pp. 59-70
-
-
Ogawa, K.1
Ishihara, S.2
Saito, Y.3
Mineta, K.4
Nakazawa, M.5
Ikeo, K.6
Gojobori, T.7
Watanabe, K.8
Agata, K.9
-
80
-
-
0032931102
-
Distinct structural domains in the planarian brain defined by the expression of evolutionarily conserved homeobox genes
-
Umesono Y., Watanabe K., and Agata K. Distinct structural domains in the planarian brain defined by the expression of evolutionarily conserved homeobox genes. Dev Genes Evol 209 (1999) 31-39
-
(1999)
Dev Genes Evol
, vol.209
, pp. 31-39
-
-
Umesono, Y.1
Watanabe, K.2
Agata, K.3
-
81
-
-
34347272302
-
Regeneration and maintenance of the planarian midline is regulated by a slit orthologue
-
Smed-slit(RNAi) causes the regeneration of neural tissue (cephalic ganglia, ventral nerve cords, and photoreceptors) that is collapsed at the midline. Ectopic neural tissue also appears at the midline even in uninjured animals, suggesting a role for slit during homeostatic maintenance of CNS organization.
-
Cebrià F., Guo T., Jopek J., and Newmark P.A. Regeneration and maintenance of the planarian midline is regulated by a slit orthologue. Dev Biol 307 (2007) 394-406. Smed-slit(RNAi) causes the regeneration of neural tissue (cephalic ganglia, ventral nerve cords, and photoreceptors) that is collapsed at the midline. Ectopic neural tissue also appears at the midline even in uninjured animals, suggesting a role for slit during homeostatic maintenance of CNS organization.
-
(2007)
Dev Biol
, vol.307
, pp. 394-406
-
-
Cebrià, F.1
Guo, T.2
Jopek, J.3
Newmark, P.A.4
-
82
-
-
34248579919
-
Morphogenesis defects are associated with abnormal nervous system regeneration following roboA RNAi in planarians
-
Knockdown of Smed-roboA causes the production of ectopic dorsal cephalic outgrowths and supernumerary pharynges, phenotypes that are correlated with a lack of connectivity between the newly regenerated brain lobes and the pre-existing ventral nerve cords. These data suggest that the planarian CNS may play a central role during regeneration, as in annelids and amphibians.
-
Cebrià F., and Newmark P.A. Morphogenesis defects are associated with abnormal nervous system regeneration following roboA RNAi in planarians. Development 134 (2007) 833-837. Knockdown of Smed-roboA causes the production of ectopic dorsal cephalic outgrowths and supernumerary pharynges, phenotypes that are correlated with a lack of connectivity between the newly regenerated brain lobes and the pre-existing ventral nerve cords. These data suggest that the planarian CNS may play a central role during regeneration, as in annelids and amphibians.
-
(2007)
Development
, vol.134
, pp. 833-837
-
-
Cebrià, F.1
Newmark, P.A.2
-
83
-
-
33751162427
-
Regulation of commissural axon pathfinding by slit and its Robo receptors
-
Dickson B.J., and Gilestro G.F. Regulation of commissural axon pathfinding by slit and its Robo receptors. Annu Rev Cell Dev Biol 22 (2006) 651-675
-
(2006)
Annu Rev Cell Dev Biol
, vol.22
, pp. 651-675
-
-
Dickson, B.J.1
Gilestro, G.F.2
-
84
-
-
54949153140
-
Comparative aspects of animal regeneration
-
Brockes J.P., and Kumar A. Comparative aspects of animal regeneration. Annu Rev Cell Dev Biol 24 (2008) 525-549
-
(2008)
Annu Rev Cell Dev Biol
, vol.24
, pp. 525-549
-
-
Brockes, J.P.1
Kumar, A.2
-
85
-
-
51049089115
-
Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea
-
Microarray-based transcriptome analysis revealed 259 genes whose expression is downregulated in planarians one and seven days after lethal irradiation. Genes downregulated early are expressed in mitotically active neoblasts, while those downregulated later are expressed primarily in postmitotic progeny. BrdU pulse-chase experiments demonstrated that cells expressing 'late' genes are the differentiating progeny of those expressing 'early' genes. Analysis using a subset of these markers to label single sorted cells revealed considerable heterogeneity among neoblasts and their immediate progeny.
-
Eisenhoffer G.T., Kang H., and Sánchez Alvarado A. Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea. Cell Stem Cell 3 (2008) 327-339. Microarray-based transcriptome analysis revealed 259 genes whose expression is downregulated in planarians one and seven days after lethal irradiation. Genes downregulated early are expressed in mitotically active neoblasts, while those downregulated later are expressed primarily in postmitotic progeny. BrdU pulse-chase experiments demonstrated that cells expressing 'late' genes are the differentiating progeny of those expressing 'early' genes. Analysis using a subset of these markers to label single sorted cells revealed considerable heterogeneity among neoblasts and their immediate progeny.
-
(2008)
Cell Stem Cell
, vol.3
, pp. 327-339
-
-
Eisenhoffer, G.T.1
Kang, H.2
Sánchez Alvarado, A.3
-
86
-
-
33847248871
-
Getting to the heart of regeneration in zebrafish
-
Poss K.D. Getting to the heart of regeneration in zebrafish. Semin Cell Dev Biol 18 (2007) 36-45
-
(2007)
Semin Cell Dev Biol
, vol.18
, pp. 36-45
-
-
Poss, K.D.1
-
87
-
-
53449094128
-
New regulators of vertebrate appendage regeneration
-
Yin V.P., and Poss K.D. New regulators of vertebrate appendage regeneration. Curr Opin Genet Dev 18 (2008) 381-386
-
(2008)
Curr Opin Genet Dev
, vol.18
, pp. 381-386
-
-
Yin, V.P.1
Poss, K.D.2
-
88
-
-
38549118507
-
The Xenopus tadpole: a new model for regeneration research
-
Slack J.M., Lin G., and Chen Y. The Xenopus tadpole: a new model for regeneration research. Cell Mol Life Sci 65 (2008) 54-63
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 54-63
-
-
Slack, J.M.1
Lin, G.2
Chen, Y.3
-
89
-
-
33750220712
-
Bridging the regeneration gap: genetic insights from diverse animal models
-
Sánchez Alvarado A., and Tsonis P.A. Bridging the regeneration gap: genetic insights from diverse animal models. Nat Rev Genet 7 (2006) 873-884
-
(2006)
Nat Rev Genet
, vol.7
, pp. 873-884
-
-
Sánchez Alvarado, A.1
Tsonis, P.A.2
-
90
-
-
34249913942
-
Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine
-
Stoick-Cooper C.L., Moon R.T., and Weidinger G. Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes Dev 21 (2007) 1292-1315
-
(2007)
Genes Dev
, vol.21
, pp. 1292-1315
-
-
Stoick-Cooper, C.L.1
Moon, R.T.2
Weidinger, G.3
-
91
-
-
28444486367
-
Stem cell niche: structure and function
-
Li L., and Xie T. Stem cell niche: structure and function. Annu Rev Cell Dev Biol 21 (2005) 605-631
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 605-631
-
-
Li, L.1
Xie, T.2
-
92
-
-
39149144034
-
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life
-
Morrison S.J., and Spradling A.C. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 132 (2008) 598-611
-
(2008)
Cell
, vol.132
, pp. 598-611
-
-
Morrison, S.J.1
Spradling, A.C.2
-
93
-
-
0036436627
-
Vertebrate limb regeneration and the origin of limb stem cells
-
Bryant S.V., Endo T., and Gardiner D.M. Vertebrate limb regeneration and the origin of limb stem cells. Int J Dev Biol 46 (2002) 887-896
-
(2002)
Int J Dev Biol
, vol.46
, pp. 887-896
-
-
Bryant, S.V.1
Endo, T.2
Gardiner, D.M.3
-
94
-
-
35748968498
-
Deciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile
-
Microarray-based analysis of gene expression in D. japonica after lethal and sublethal irradiation identified 60 downregulated and 63 upregulated genes, respectively. Expression of a subset of the downregulated genes in neoblasts was verified by in situ hybridization; not all genes are co-expressed, indicating heterogeneity of the stem cell population.
-
Rossi L., Salvetti A., Marincola F.M., Lena A., Deri P., Mannini L., Batistoni R., Wang E., and Gremigni V. Deciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile. Genome Biol 8 (2007) R62. Microarray-based analysis of gene expression in D. japonica after lethal and sublethal irradiation identified 60 downregulated and 63 upregulated genes, respectively. Expression of a subset of the downregulated genes in neoblasts was verified by in situ hybridization; not all genes are co-expressed, indicating heterogeneity of the stem cell population.
-
(2007)
Genome Biol
, vol.8
-
-
Rossi, L.1
Salvetti, A.2
Marincola, F.M.3
Lena, A.4
Deri, P.5
Mannini, L.6
Batistoni, R.7
Wang, E.8
Gremigni, V.9
|