A method for acetonitrile-free microcystin analysis and purification by high-performance liquid chromatography, using methanol as mobile phase

Toxicon

Volumn 54, Issue 6, 2009, Pages 887-890

  Purdie, Esme L ^a   Young, Fiona M ^a   Menzel, Diana ^a   Codd, Geoffrey A ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Analysis; Cyanobacteria; HPLC; Methanol; Microcystin

Indexed keywords

ACETONITRILE; METHANOL; MICROCYSTIN;

ARTICLE; CONTROLLED STUDY; CYANOBACTERIUM; ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER TOXICITY; PRIORITY JOURNAL; PURIFICATION; TOXIN ANALYSIS;

ACETONITRILES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MICROCYSTINS; MICROCYSTIS; SPECTROPHOTOMETRY, ULTRAVIOLET;

CYANOBACTERIA;

EID: 68949157282     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.06.016     Document Type: Article

References (12)

1. Codd G.A., Morrison L.F., and Metcalf J.S. Cyanobacterial toxins: risk management for health protection. Toxicol. Appl. Pharmacol. 203 (2005) 264-272
2. Carmichael W. A world overview- One-hundred-twenty-seven years of research on toxic cyanobacteria - where do we go from here?. Adv. Exp. Med. Biol. 619 (2008) 104-125
3. Fastner J., Codd G.A., Metcalf J.S., Woitke P., Wiedner C., and Utkilen H. An international comparison exercise for the determination of purified microcystin-LR and microcystins in field material. Anal. Bioanal. Chem. 374 (2002) 437-444
4. Lawton L., Edwards C., and Codd G.A. Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters. Analyst 119 (1994) 1525-1530
5. Lawton L., McElhiney J., and Edwards C. Purification of closely eluting hydrophobic microcystins (peptide cyanotoxins) by normal-phase and reverse-phase flash chromatography. J. Chromatogr. A 848 (1999) 515-522
6. In: Meriluoto J., and Codd G.A. (Eds). Toxic Cyanobacterial Monitoring and Cyanotoxin Analysis (2005), Abo Akademi University Press, Abo, Finland 149
7. Metcalf J.S., and Codd G.A. Analysis of cyanobacterial toxins by immunological methods. Chem. Res. Toxicol. 16 (2003) 103-112
8. Pyo D., and Shin H. Supercritical fluid extraction of microcystin-LR from cyanobacteria. Anal. Chem. 71 (1999) 4772-4775
9. Spoof L. Microcystins and nodularins. In: Meriluoto J., and Codd G.A. (Eds). Toxic Cyanobacterial Monitoring and Cyanotoxin Analysis (2005), Abo Akademi University Press, Abo, Finland 15-39
10. 18 column. J. Chromatogr. A 947 (2002) 237-245
11. Snyder L.R., Kirkland J.J., and Glajch J.L. Practical HPLC Method Development. second ed. (1997), John Wiley and Sons Inc., Hobroken, New Jersey, USA
12. Tullo A. A solvent dries up. Chem. Eng. News 86 47 (2008) 27