Positional effects of monofluorinated phenylalanines on histone acetyltransferase stability and activity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 18, 2009, Pages 5449-5451

  Voloshchuk, Natalya ^a,b   Zhu, Anita Y ^a,b   Snydacker, David ^a,b   Montclare, Jin Kim ^a,b  

^a POLYTECHNIC UNIVERSITY   (United States)

^b SUNY Downstate Medical Center   (United States)

Author keywords

Activity; Fluorinated amino acids; Histone acetyltransferase; Protein design; Stability

Indexed keywords

2 FLUOROPHENYLALANINE; 3 FLUOROPHENYLALANINE; 4 FLUOROPHENYLALANINE; AROMATIC AMINO ACID; FLUORINE DERIVATIVE; HISTONE ACETYLTRANSFERASE; PHENYLALANINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DIPOLE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME STABILITY; ENZYME STRUCTURE; MOLECULAR SIZE; PROTEIN FUNCTION;

ANIMALS; ENZYME STABILITY; HISTONE ACETYLTRANSFERASES; MODELS, MOLECULAR; P-FLUOROPHENYLALANINE; PHENYLALANINE; PROTEIN CONFORMATION; PROTEIN ENGINEERING; TETRAHYMENA THERMOPHILA;

EID: 68949135519     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.093     Document Type: Article

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