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(b) Jones, P.; Kinzel, O.; Llauger Bufi, L.; Muraglia, E.; Pescatore, G.; Torrisi, C. WO2007/138355 2007.
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Bhattacharjee, A.; Yanming, D.; Duffy, E. M.; Job, G. E.; Lou, R.; Lou, Z.; O'Dowd, H.; Tang, Y.; Wu, Y. WO2008/106224 2008.
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(c) Bhattacharjee, A.; Yanming, D.; Duffy, E. M.; Job, G. E.; Lou, R.; Lou, Z.; O'Dowd, H.; Tang, Y.; Wu, Y. WO2008/106224 2008.
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68949129608
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Xia, Y.; Boyle, C. D.; Greenlee, W. J.; Chackalamannil, S.; Jayne, C. L.; Stamford, A. W.; Dai, X.; Harris, J. M.; Neustadt, B. R.; Neelamkavil, S. F.; Shah, U. G.; Lankin, C. M.; Liu, H. WO 2009/055331 2009. See pp 242-243. A 10 mg portion of compound 11 was prepared in four steps and 16% overall yield from diethyl 3-(benzyloxy)cyclobutane-1,1-dicar-boxylate.
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Xia, Y.; Boyle, C. D.; Greenlee, W. J.; Chackalamannil, S.; Jayne, C. L.; Stamford, A. W.; Dai, X.; Harris, J. M.; Neustadt, B. R.; Neelamkavil, S. F.; Shah, U. G.; Lankin, C. M.; Liu, H. WO 2009/055331 2009. See pp 242-243. A 10 mg portion of compound 11 was prepared in four steps and 16% overall yield from diethyl 3-(benzyloxy)cyclobutane-1,1-dicar-boxylate.
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15
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68949092765
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Molecular overlays were prepared from structures minimized using MacroModel, Version 9.0; Schrodinger, LLC: New York, 2005 OPLS 2005 force-field, with GB/SA water solvation model, The homopiperidine derivative was subjected to a conformational search to identify the global minimimum conformation. Distances indicated are CsN distances determined from minimized structures
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Molecular overlays were prepared from structures minimized using MacroModel, Version 9.0; Schrodinger, LLC: New York, 2005 (OPLS 2005 force-field, with GB/SA water solvation model). The homopiperidine derivative was subjected to a conformational search to identify the global minimimum conformation. Distances indicated are CsN distances determined from minimized structures.
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and references therein. Brook, P. R.; Griffiths, J. G. Chem. Commun. 1970, 1344.
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(b) Kaneko, T.; Clark, R. S. J.; Ohi, N.; Ozaki, F.; Kawahara, T.; Kamada, A.; Okano, K.; Yokohama, H.; Ohkuro, M.; Muramoto, K.; Takenaka, O.; Kobayashi, S. Chem. Pharm. Bull. 2004, 52, 675.
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68949106398
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We have noticed in similar [2, 2] reactions using zinc-copper couple that a violent exotherm may develop, especially when using THF as the solvent
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We have noticed in similar [2 + 2] reactions using zinc-copper couple that a violent exotherm may develop, especially when using THF as the solvent.
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