Piperidine carboxylic acid derivatives of 10H-pyrazino[2,3-b][1,4] benzothiazine as orally-active adhesion molecule inhibitors

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 6, 2004, Pages 675-687

  Kaneko, Toshihiko ^a   Clark, Richard S J ^a   Ohi, Norihito ^a   Ozaki, Fumihiro ^a   Kawahara, Tetsuya ^a   Kamada, Atsushi ^a   Okano, Kazuo ^a   Yokohama, Hiromitsu ^a   Ohkuro, Masayoshi ^a   Muramoto, Kenzo ^a   Takenaka, Osamu ^a   Kobayashi, Seiichi ^b  

^a EISAI CO LTD   (Japan)

^b EISAI RESEARCH INSTITUTE   (United States)

Author keywords

10H pyrazino 2,3 b 1,4 benzothiazine; Adhesion molecule inhibitor; ER 49890

Indexed keywords

3 [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]PROPIONIC ACID; 3 [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]PROPYNOIC ACID; 4 [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL] 2 METHYLBUTANOIC ACID; 4 [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL] 2 METHYLBUTENOIC ACID; 4 [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]BENZOIC ACID; 4 [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]PHENYLACETIC ACID; 4 [1 [2 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YL)CARBONYL]PIPERIDIN 4 YL] 2 METHYLBUTANOIC ACID; 4 [1 [2 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YL)ETHYL]PIPERIDIN 4 YL] 2 METHYLBUTANOIC ACID; 4 [1 [2 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YL)METHYL]PIPERIDIN 4 YL] 2,2 DIMETHYLBUTANOIC ACID; [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]ACETIC ACID; [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]AMINOACETIC ACID; [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]CARBOXYLIC ACID; [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]OXYACETIC ACID; [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]THIOACETIC ACID; [3 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL) 3 AZABICYCLO[3.3.1]NON 9 YL]ACETIC ACID; [3 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL) 3 AZABICYCLO[3.3.1]NON 9 YLIDENE]ACETIC ACID; [3 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL) 7 OXO 3 AZABICYCLO[3.2.1]OCT 8 YL]ACETIC ACID; [3 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL) 7 OXO 3 AZABICYCLO[3.3.1]NON 9 YL]ACETIC ACID; [7 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL) 7 AZASPIRO[3.5]NON 2 YL]ACETIC ACID; [7 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL) 7 AZASPIRO[3.5]NON 2 YL]CARBOXYLIC ACID; [8 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL) 8 AZABICYCLO[3.2.1]OCT 3 YL]ACETIC ACID; CARBOXYLIC ACID DERIVATIVE; CELL ADHESION MOLECULE; ER 49890; ETHYL 3 [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]PROPIONATE; ETHYL 3 [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]PROPYNATE; ETHYL 4 [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL] 2 METHYLBUTANOATE; ETHYL [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]ACETATE; ETHYL [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]AMINOACETATE; ETHYL [1 (10H PYRAZINO[2,3 B][1,4]BENZOTHIAZIN 8 YLMETHYL)PIPERIDIN 4 YL]CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; BENZOTHIADIAZINE DERIVATIVE; CARBOXYLIC ACID; INTERCELLULAR ADHESION MOLECULE 1; PIPERIDINE DERIVATIVE; THIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CELL MIGRATION; INFLAMMATION; LEUKOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PLEURISY; RAT; UPREGULATION; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; FEMALE; FISCHER 344 RAT; LEWIS RAT; MALE; ORAL DRUG ADMINISTRATION; PHYSIOLOGY;

ADMINISTRATION, ORAL; ANIMALS; BENZOTHIADIAZINES; CARBOXYLIC ACIDS; CELL ADHESION MOLECULES; FEMALE; INTERCELLULAR ADHESION MOLECULE-1; MALE; PIPERIDINES; RATS; RATS, INBRED F344; RATS, INBRED LEW; THIAZINES;

EID: 16544377027     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.675     Document Type: Article

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