A Method for Differentiating Targeted Microbubbles in Real Time Using Subharmonic Micro-Ultrasound and Interframe Filtering

Ultrasound in Medicine and Biology

Volumn 35, Issue 9, 2009, Pages 1564-1573

  Needles, A ^a   Couture, O ^a   Foster, F S ^a  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

Contrast agent; High frequency ultrasound; Interframe filtering; Small animal imaging; Subharmonic imaging; Targeted microbubble

Indexed keywords

CONTRAST AGENT; HIGH-FREQUENCY ULTRASOUND; INTERFRAME FILTERING; SMALL ANIMAL IMAGING; SUBHARMONIC IMAGING; TARGETED MICROBUBBLE;

ACOUSTIC WAVES; ANIMALS; BUBBLES (IN FLUIDS); MEDICAL IMAGING; ULTRASONIC APPLICATIONS; ULTRASONIC DEVICES; ULTRASONICS;

ULTRASONIC IMAGING;

ACCURACY; ANALYTIC METHOD; ARTICLE; B SCAN; BLOOD PRESSURE; ECHOGRAPHY; FEASIBILITY STUDY; FILTRATION; FREQUENCY MODULATION; HEMODYNAMICS; IMAGE PROCESSING; IMAGING SYSTEM; MICROBUBBLE; PHANTOM; PRIORITY JOURNAL; TISSUE BLOOD FLOW;

ANIMALS; CONTRAST MEDIA; FEASIBILITY STUDIES; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MICROBUBBLES; MICROTECHNOLOGY; PHANTOMS, IMAGING; SIGNAL PROCESSING, COMPUTER-ASSISTED; ULTRASONOGRAPHY;

EID: 68949100454     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2009.04.006     Document Type: Article

References (34)

1. Burns P.N., Powers J.E., Hope-Simpson D., Brezina A., Kolin A., Chin C.T., Uhlendorf V., and Fritzsch T. Harmonic power mode Doppler using contrast agents: An improved method for small vessel flow imaging. J Ech Med Ultra 16 (1994) 132-142
2. Brown J.A., Foster F.S., Needles A., and Lockwood G.R. A 40 MHz linear array based on a 1-3 composite with geometric elevation focusing. Vancouver Proc IEEE Ultrason Symp (2006) 256-259
3. Butler M.B., Moran C.M., Anderson T., Cunningham C., Ross J.A., Easson W., Fox K.A.A., and McDicken W.N. Laser Doppler anemometry measurements of the shear stresses on ultrasonic contrast agent microbubbles attached to agar. Ultrasound Med Biol 31 (2005) 545-552
4. Cobbold R.S.C. Foundations of Biomedical Ultrasound (2006), Oxford University Press, Oxford
5. Couture O., Rychak J.J., and Foster F.S. A new model for the maximum reflectivity enhancement from targeted contrast agents (2006), Proc IEEE Ultrason Symp, Vancouver 1548-1551
6. Dayton P.A., Morgan K.E., Klibanov A.L., Brandenburger G., Nightingale K.R., and Ferrara K.W. A preliminary evaluation of the effects of primary and secondary radiation forces on acoustic contrast agents. IEEE Trans Ultrason Ferroelectr Freq Control 44 (1997) 1264-1277
7. de Jong N., Frinking P.J.A., Buoakaz A., and Ten Cate F.J. Detection procedures of ultrasound contrast agents. Ultrasonics 38 (2000) 87-92
8. Demos S.M., Alkan-Onyuksel H., Kane B.J., Ramani K., Nagaraj A., Greene R., Klegerman M., and McPherson D.D. In vivo targeting of acoustically reflective liposomes for intravascular and transvascular ultrasonic enhancement. J Am Coll Cardiol 33 (1999) 867-875
9. Deng C.X., and Lizzi F.L. A review of physical phenomena associated with ultrasonic contrast agents and illustrative clinical phenomena. Ultrasound Med Biol 28 (2002) 277-286
10. Foster F.S., Pavlin C.J., Harasiewicz K.A., Christopher D.A., and Turnbull D.H. Advances in ultrasound biomicroscopy. Ultrasound Med Biol 26 (2000) 1-27
11. Foster F.S., Zhang M.Y., Zhou Y.Q., Liu G., Mehi J., Cherin E., Harasiewicz K.A., Starkoski B.G., Zan L., Knapik D.A., and Adamson S.L. A new ultrasound instrument for in vivo microimaging of mice. Ultrasound Med Biol 28 (2002) 1165-1172
12. Goertz D.E., Yu J.L., Kerbel R.S., Burns P.N., and Foster F.S. High-frequency 3D color flow imaging of the microcirculation. Ultrasound Med Biol 29 (2003) 39-51
13. Goertz D.E., van Wamel A., Frijlink M.E., de Jong N., and van der Steen A.F.W. Nonlinear imaging of targeted microbubbles with intravascular ultrasound (2005), Proc IEEE Ultrason Symp, Rotterdam 2003-2006
14. Goertz D.E., Cherin E., Needles A., Karshafian R., Brown A.S., Burns P.N., and Foster F.S. High frequency nonlinear B-Scan imaging of microbubble contrast agents. IEEE Trans Ultrason Ferroelectr Freq Control 52 (2005) 65-79
15. Goertz D.E., Needles A., Burns P.N., and Foster F.S. High frequency nonlinear flow imaging of microbubble contrast agents. IEEE Trans Ultrason Ferroelectr Freq Control 52 (2005) 495-502
16. Goertz D.E., Frijlink M.E., de Jong N., and van der Steen A.F.W. Nonlinear intravascular ultrasound contrast imaging. Ultrasound Med Biol 32 (2006) 491-502
17. Hope-Simpson D., Chin C.T., and Burns P.N. Pulse inversion Doppler: A new method for detecting non-linear echoes from microbubble contrast agents. IEEE Trans Ultrason Ferroelectr Freq Control 46 (1999) 372-382
18. Kadi A.P., and Loupus T. On the perfromance of regression and step initialized IIR clutter filters for color Doppler systems in diagnostic medical ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control 42 (1995) 927-938
19. v-integrins. Circulation 107 (2003) 455-460
20. Lindner J.R. Molecular imaging with contrast ultrasound and targeted microbubbles. J Nucl Cardiol 11 (2004) 215-221
21. Lukacs M., Yin J., Pang G., Garcia R.C., Cherin E., Williams R., Mehi J., and Foster F.S. Performance and characterization of new micromachined high-frequency linear arrays. IEEE Trans Ultrason Ferroelectr Freq Control 53 (2006) 1719-1729
22. Lum A.F.H., Borden M.A., Dayton P.A., Peng L., Kruse D.E., Simon S.I., Lam K.S., and Ferrara K.W. Ultrasound radiation force enables targeted deposition of molecularly targeted nanoparticles loaded on microbubbles under flow conditions (2006), Proc IEEE Ultrason Symp, Vancouver 108-111
23. Needles A., Goertz D.E., Cheung A.M., and Foster F.S. Interframe clutter filtering for high frequency flow imaging. Ultrasound Med Biol 33 (2007) 591-600
24. Needles A., Graba J., Bilan C., Coulthard T., Hirson D., Foster F.S., Goertz D.E., and Stapleton S. A new real-time high-frequency subharmonic contrast mode for mouse imaging (2007), Proc IEEE Ultrason Symp, New York 1069-1072
25. Needles A., Goertz D.E., Karshafian R., Cherin E., Brown A.S., Burns P.N., and Foster F.S. High-frequency subharmonic pulsed-wave Doppler and color flow imaging of microbubble contrast agents. Ultrasound Med Biol (2008) in press
26. Newhouse V.L., and Reid J.M. Invariance of the transverse Doppler bandwidth with flow displacement (1990), Proc IEEE Ultrason Symp, Honolulu 1553-1536
27. Ritter T.A., Shrout T.R., Tutweiler R., and Shung K.K. A 30 MHz peizo-composite ultrasound array for medical imaging applications. IEEE Ultrason Ferroelectr Freq Control 49 (2002) 217-230
28. Rychak J.J., Klibanov A.L., and Hossack J.A. Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: In vitro verification. IEEE Trans Ultrason Ferroelectr Freq Control 52 (2005) 421-433
29. Rychak J.J., Graba J., Cheung A.M., Mystry B.S., Lindner J.R., Kerbel R.S., and Foster F.S. Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis. Mol Imaging 6 (2007) 289-296
30. Torp H. Clutter rejection filters in color flow imaging: A theoretical approach. IEEE Trans Ultrason Ferroelectr Freq Control 44 (1997) 417-424
31. Tortoli P., Bagnai D., and Righi D. Qantitative analysis of Doppler spectrum modifications yielded by contrast agents insonified at high pressure. IEEE Trans Ultrason Ferroelectr Freq Control 46 (1999) 247-251
32. van Wamel A., Garbin V., Vos R., Overvelde M., Sijl J., Emmer M., Lohse D., Versluis M., and de Jong N. Targeted versus free circulating ultrasound contrast agents: Towards new molecular imaging strategies. World Molecular Imaging Congress (2008), Nice, France
33. Weller G.E.R., Wong M.K.K., Modzelewski R.A., Lu E., Klibanov A.L., Wagner W.R., and Villanueva F.S. Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine. Cancer Res 65 (2005) 533-539
34. Zhao S., Kruse D.E., Ferrara K.W., and Dayton P.A. Selective imaging of adherent targeted ultrasound contrast agents. Phys Med Biol 52 (2007) 2055-2072