Mechanisms and kinetics of human arylamine N-acetyltransferase 1 inhibition by disulfiram

FEBS Journal

Volumn 276, Issue 17, 2009, Pages 4900-4908

  Malka, Florence ^a   Dairou, Julien ^a   Ragunathan, Nilusha ^a   Dupret, Jean Marie ^a   Rodrigues Lima, Fernando ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Arylamine N acetyltransferase; Cancer; Drug target; Inhibition; Kinetics

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; DISULFIRAM; RECOMBINANT ENZYME; THIOL GROUP;

ARTICLE; CANCER CELL; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL;

ALCOHOL DETERRENTS; ARYLAMINE N-ACETYLTRANSFERASE; CATALYTIC DOMAIN; CELL LINE, TUMOR; CYSTEINE; DISULFIRAM; ENZYME ACTIVATION; HUMANS; ISOENZYMES; KINETICS; RECOMBINANT PROTEINS;

EID: 68849122531     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07189.x     Document Type: Article

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