The pathogenesis of chronic inflammation and malignant transformation in the human upper airways: The role of beta-defensins, eNOS, cell proliferation and apoptosis

Histology and Histopathology

Volumn 24, Issue 7, 2009, Pages 815-820

  Pacova, H ^a,b   Astl, J ^a   Martinek, J ^b  

^a UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Apoptosis; Defensins; Nasal polyposis; Proliferation; Tonsillar carcinoma; Tonsillitis chronica

Indexed keywords

BETA DEFENSIN; CASPASE 3; ENDOTHELIAL NITRIC OXIDE SYNTHASE; KI 67 ANTIGEN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL TRANSFORMATION; CHRONIC DISEASE; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; IMMUNOLOGY; INFLAMMATION; METABOLISM; NOSE MUCOSA; NOSE POLYP; PATHOLOGY; TONSIL TUMOR; TONSILLITIS;

APOPTOSIS; BETA-DEFENSINS; CASPASE 3; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHRONIC DISEASE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; INFLAMMATION; KI-67 ANTIGEN; NASAL MUCOSA; NASAL POLYPS; NITRIC OXIDE SYNTHASE TYPE III; TONSILLAR NEOPLASMS; TONSILLITIS;

EID: 68849116504     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Blais V. and Rivest S. (2001). Inhibitory action of nitric oxide on circulating tumor necrosis factor-induced NF-knB activity and COX-2 transcription in the endothelium of the brain capillaries. J. Neuropathol. Exp. Neurol. 60, 893-905.
2. Brouet A., deWever J., Martinive P., Havaux X., Bouzin C., Sonveaux P. and Feron O. (2005). Antitumor effects of in vivo caveolin gene delivery are associated with the inhibition of the proangiogenic and vasodilatory effects of nitric oxide. FASEB J. 19, 602-604.
3. Carothers D.G., Graham S.M., Jia H.P., Ackermann M.R., Tack B.F. and McCray P.B. Jr. (2001). Production of beta-defensin antimicrobial peptides by maxillary sinus mucosa. Am. J. Rhinol. 15, 175-179.
4. Chae S.W., Lee S.H., Cho J.H., Lee H.M., Choi G. and Hwang S.J. (2001). Expression of human beta defensin 1 mRNA in human palatine tonsil. Acta Otolaryngol. 121, 414-418.
5. Diamond D.L., Kimball J.R., Krisanaprakornkit S., Ganz T. and Dale B.A. (2001). Detection of beta-defensins secreted by human oral epithelial cells. J. Immunol. Methods. 256, 65-76.
6. Duda D.G., Fukumura D. and Jain R.K. (2004). Role of eNOS in neovascularization: NO for endothelial progenitor cells. Trends Mol. Med. 10, 143-145.
7. Dunsche A., Acil Y., Siebert R., Harder J., Schroder J.M. and Jepsen S. (2001). Expression profile of human defensins and antimicrobial proteins in oral tissues. J. Oral. Pathol. Med. 30, 154-158.
8. Dunsche A., Acil Y., Dommisch H., Siebert R., Schroder J.M. and Jepsen S. (2002). The novel human beta-defensin-3 is widely expressed in oral tissues. Eur. J. Oral. Sci. 110, 121-124.
9. Fukumura D., Kashiwagi S. and Jain R.K. (2006). The role of nitric oxide in tumor progression. Nat. Rev. Cancer 6, 521-534.
10. Grabenbauer G.G., Mühlfriedel C., Rödel F., Niedobitek G., Hornung J., Rödel C., Martus P., Iro H., Kirchner T., Steininger H., Sauer R., Weidenbecher M. and Distel L. (2000). Squamous cell carcinoma of the oropharynx: Ki-67 and p53 can identify patients at high risk for local recurrence after surgery and postoperative radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 48, 1041-1050.
11. Hellings P., Jorissen M. and Ceuppens J.L. (2000). The Waldayer's ring. Acta Otorhinolaryngol. Belg. 54, 237-241.
12. Jadeski L.C., Hum K.O., Chakraborty C. and Lala P.K. (2006). Nitric oxide promotes murine mammary tumor growth and metastesis by stimulating tumor cell migration, invasiveness, and angiogenesis. Int. J. Cancer 86, 30-39.
13. Lancaster J.R. Jr and Xie K. (2006), Tumors face NO problems? Cancer Res. 66, 6459-6462.
14. Lee S.H., Kim J.E., Lim H.H., Lee H.M. and Choi J.O. (2002). Antimicrobial defensin peptides of the human nasal mucosa. Ann. Otol. Rhinol. Laryngol. 111, 135-141.
15. Li C.Q. and Wogan G.N. (2005). Nitric oxide as a modulator of apoptosis. Cancer Lett. 226, 1-15.
16. Meyer J.E., Beier U.H., Görögh T., Schreiber S., Beck C. and Maune S. (2006). Defensin and chemokine expression patterns in the palatine tonsil: a model of their local interaction. Eur. Arch. Otorhinolaryngol. 263, 319-326.
17. Mizukawa N., Sawaki K., Yamachika E., Fukunaga J., Ueno T., Takagi S. and Sugahara T. (2000). Presence of human beta-defensin-2 in oral squamous cell carcinoma. Anticancer Res. 20, 2005-2007.
18. Namkoong S., Lee S.J., Kim C.K., Kim Y.M., Chung H.T., Lee H., Han J.A., Ha K.S. and Kwon Y.G. (2005). Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells. Exp. Mol. Med. 37, 588-600.
19. Sawaki K., Mizukawa N., Yamaai T., Yoshimoto T., Nakano M. and Sugahara T. (2002). High concentration of beta-defensin-2 in oral squamous cell carcinoma. Anticancer Res. 22, 2103-2107.
20. Shang Z.J., Li Z.B. and Li R.J. (2006). In vitro effects of nitric oxide Synthase inhibitor L-NAME on oral squamous cell carcinoma: a preliminary study. Int. J. Oral. Maxillofac. Surg. 35, 539-543.
21. Wang C., Dong Z. and Yang Z. (2004). Expression of human betadefensin in palatine tonsil. Lin. Chuang. Er. Bi. Yan. Hou. Ke. Za. Zhi. 18, 129-131.
22. Weise J.B., Meyer J.E., Helmer H., Wittrock H. and Maune S. (2002). A newly discovered function of palatine tonsils in immune defence: the expression of defensins. Otolaryngol. Pol. 56, 409-413.
23. Ying L. and Hofseth.LJ. (2007). An emerging role for endothelial nitric oxide Synthase in chronic inflammation and cancer. Cancer Res. 67, 1407-1410.
24. Yoshimoto T., Yamaai T., Mizukawa N., Sawaki K., Nakano M., Yamachika E. and Sugahara T. (2003). Different expression patterns of beta-defensins in human squamous cell carcinomas. Anticancer Res. 23, 4629-4633.