Constrained tibial vibration does not produce an anabolic bone response in adult mice

Bone

Volumn 45, Issue 4, 2009, Pages 750-759

  Christiansen, Blaine A ^a   Kotiya, Akhilesh A ^a   Silva, Matthew J ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

CTV; Mechanical loading; MicroCT; Vibration; WBV

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MASS; BONE STRESS; C57BL 6 MOUSE; CONSTRAINED TIBIAL VIBRATION; CONTROLLED STUDY; CORTICAL BONE; LOADING TEST; MECHANICAL STRESS; MOUSE; NONHUMAN; OSSIFICATION; SHAM PROCEDURE; TIBIA; TRABECULAR BONE; VIBRATION;

AGING; ANIMALS; BODY WEIGHT; MICE; OSTEOGENESIS; TIBIA; TIME FACTORS; VIBRATION; WEIGHT-BEARING; X-RAY MICROTOMOGRAPHY;

EID: 68849111336     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.06.025     Document Type: Article

References (43)

1. Christiansen B.A., and Silva M.J. The effect of varying magnitudes of whole-body vibration on several skeletal sites in mice. Ann. Biomed. Eng. 34 7 (2006) 1149-1156
2. Judex S., Donahue L.R., and Rubin C. Genetic predisposition to low bone mass is paralleled by an enhanced sensitivity to signals anabolic to the skeleton. FASEB J. 16 10 (2002) 1280-1282
3. Rubin C., Turner A.S., Bain S., Mallinckrodt C., and McLeod K. Anabolism. Low mechanical signals strengthen long bones. Nature 412 6847 (2001) 603-604
4. Rubin C., Turner A.S., Mallinckrodt C., Jerome C., McLeod K., and Bain S. Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone. Bone 30 3 (2002) 445-452
5. Verschueren S.M., Roelants M., Delecluse C., Swinnen S., Vanderschueren D., and Boonen S. Effect of 6-month whole body vibration training on hip density, muscle strength, and postural control in postmenopausal women: a randomized controlled pilot study. J. Bone Miner. Res. 19 3 (2004) 352-359
6. Ward K., Alsop C., Caulton J., Rubin C., Adams J., and Mughal Z. Low magnitude mechanical loading is osteogenic in children with disabling conditions. J. Bone Miner. Res. 19 3 (2004) 360-369
7. Judex S., Lei X., Han D., and Rubin C. Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude. J. Biomech. 40 6 (2007) 1333-1339
8. Rubin C., Turner A.S., Muller R., Mittra E., McLeod K., Lin W., et al. Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. J. Bone Miner. Res. 17 2 (2002) 349-357
9. Flieger J., Karachalios T., Khaldi L., Raptou P., and Lyritis G. Mechanical stimulation in the form of vibration prevents postmenopausal bone loss in ovariectomized rats. Calcif. Tissue Int. 63 6 (1998) 510-514
10. Oxlund B.S., Ortoft G., Andreassen T.T., and Oxlund H. Low-intensity, high-frequency vibration appears to prevent the decrease in strength of the femur and tibia associated with ovariectomy of adult rats. Bone 32 1 (2003) 69-77
11. Rubin C.T., Sommerfeldt D.W., Judex S., and Qin Y. Inhibition of osteopenia by low magnitude, high-frequency mechanical stimuli. Drug Discov. Today 6 16 (2001) 848-858
12. Rubin C., Xu G., and Judex S. The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli. Faseb J. 15 12 (2001) 2225-2229
13. Rubin C., Recker R., Cullen D., Ryaby J., McCabe J., and McLeod K. Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety. J. Bone Miner. Res. 19 3 (2004) 343-351
14. Xie L., Jacobson J.M., Choi E.S., Busa B., Donahue L.R., Miller L.M., et al. Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeleton. Bone 39 5 (2006) 1059-1066
15. Rubin C.T., and Lanyon L.E. Regulation of bone formation by applied dynamic loads. J. Bone Joint Surg. Am. 66 3 (1984) 397-402
16. Rubin C.T., and Lanyon L.E. Regulation of bone mass by mechanical strain magnitude. Calcif. Tissue Int. 37 4 (1985) 411-417
17. Frost H.M. Mechanical determinants of bone modeling. Metab. Bone Dis. Relat. Res. 4 4 (1982) 217-229
18. Kappa Delta Award paper. Rubin C.T., and Lanyon L.E. Osteoregulatory nature of mechanical stimuli: function as a determinant for adaptive remodeling in bone. J. Orthop. Res. 5 2 (1987) 300-310
19. Lanyon L.E. Functional strain as a determinant for bone remodeling. Calcif. Tissue Int. 36 Suppl. 1 (1984) S56-S61
20. Goodship A.E., Lanyon L.E., and McFie H. Functional adaptation of bone to increased stress. An experimental study. J. Bone Joint Surg. Am. 61 4 (1979) 539-546
21. Lanyon L.E., Magee P.T., and Baggott D.G. The relationship of functional stress and strain to the processes of bone remodelling. An experimental study on the sheep radius. J. Biomech. 12 8 (1979) 593-600
22. Hsieh Y.F., Robling A.G., Ambrosius W.T., Burr D.B., and Turner C.H. Mechanical loading of diaphyseal bone in vivo: the strain threshold for an osteogenic response varies with location. J. Bone Miner. Res. 16 12 (2001) 2291-2297
23. Garman R., Gaudette G., Donahue L.R., Rubin C., and Judex S. Low-level accelerations applied in the absence of weight bearing can enhance trabecular bone formation. J. Orthop. Res. 25 6 (2007) 732-740
24. Prisby R.D., Lafage-Proust M.H., Malaval L., Belli A., and Vico L. Effects of whole body vibration on the skeleton and other organ systems in man and animal models: what we know and what we need to know. Ageing Res. Rev. 7 4 (2008) 319-329
25. Christiansen B.A., Bayly P.V., and Silva M.J. Constrained tibial vibration in mice: a method for studying the effects of vibrational loading of bone. J. Biomech. Eng. 130 4 (2008) 044502
26. Hildebrand T., Laib A., Muller R., Dequeker J., and Ruegsegger P. Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J. Bone Miner. Res. 14 7 (1999) 1167-1174
27. Baron R., Vignery A., Neff L., Silverglate A., and Santa Maria A. Processing of undecalcified bone specimens for bone histomorphometry. In: Recker R. (Ed). Bone histomorphometry: techniques and interpretations (1983) 13-19
28. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2 6 (1987) 595-610
29. Rubin C.T. Skeletal strain and the functional significance of bone architecture. Calcif. Tissue Int. 36 Suppl. 1 (1984) S11-S18
30. Rubin C.T., and Lanyon L.E. Dynamic strain similarity in vertebrates; an alternative to allometric limb bone scaling. J. Theor. Biol. 107 2 (1984) 321-327
31. Mosley J.R., March B.M., Lynch J., and Lanyon L.E. Strain magnitude related changes in whole bone architecture in growing rats. Bone 20 3 (1997) 191-198
32. Mosley J.R., and Lanyon L.E. Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats. Bone 23 4 (1998) 313-318
33. Judex S., and Zernicke R.F. High-impact exercise and growing bone: relation between high strain rates and enhanced bone formation. J. Appl. Physiol. 88 6 (2000) 2183-2191
34. LaMothe J.M., Hamilton N.H., and Zernicke R.F. Strain rate influences periosteal adaptation in mature bone. Med. Eng. Phys. 27 4 (2005) 277-284
35. Campbell G.M., Buie H.R., and Boyd S.K. Signs of irreversible architectural changes occur early in the development of experimental osteoporosis as assessed by in vivo micro-CT. Osteoporos. Int. 19 10 (2008) 1409-1419
36. Glatt V., Canalis E., Stadmeyer L., and Bouxsein M.L. Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J. Bone Miner. Res. 22 8 (2007) 1197-1207
37. Rubin C.T., Capilla E., Luu Y.K., Busa B., Crawford H., Nolan D.J., et al. Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals. Proc. Natl. Acad. Sci. U. S. A. 104 45 (2007) 17879-17884
38. Xie L., Rubin C., and Judex S. Enhancement of the adolescent murine musculoskeletal system using low-level mechanical vibrations. J. Appl. Physiol. 104 4 (2008) 1056-1062
39. Hotchkiss C.E., Brommage R., Du M., and Jerome C.P. The anesthetic isoflurane decreases ionized calcium and increases parathyroid hormone and osteocalcin in cynomolgus monkeys. Bone 23 5 (1998) 479-484
40. Dobnig H., and Turner R.T. The effects of programmed administration of human parathyroid hormone fragment (1-34) on bone histomorphometry and serum chemistry in rats. Endocrinology 138 11 (1997) 4607-4612
41. Sugiyama T., Saxon L.K., Zaman G., Moustafa A., Sunters A., Price J.S., et al. Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice. Bone 43 2 (2008) 238-248
42. Fritton J.C., Myers E.R., Wright T.M., and van der Meulen M.C. Bone mass is preserved and cancellous architecture altered due to cyclic loading of the mouse tibia after orchidectomy. J. Bone Miner. Res. 23 5 (2008) 663-671
43. De Souza R.L., Matsuura M., Eckstein F., Rawlinson S.C., Lanyon L.E., and Pitsillides A.A. Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element. Bone 37 6 (2005) 810-818