메뉴 건너뛰기




Volumn 27, Issue 3, 2009, Pages 216-220

Prescribing statins to patients with nonalcoholic fatty liver disease: Real cardiovascular benefits outweigh theoretical hepatotoxic risk

Author keywords

Cardiovascular risk; Hepatotoxicity; Metabolic syndrome; NAFLD; Statins

Indexed keywords

ALANINE AMINOTRANSFERASE; ATORVASTATIN; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PLACEBO; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN;

EID: 68849103648     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/j.1755-5922.2009.00088.x     Document Type: Review
Times cited : (24)

References (42)
  • 1
    • 49649091383 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: An overview of prevalence, diagnosis, pathogenesis and treatment considerations
    • Preiss D, Sattar N. Non-alcoholic fatty liver disease: An overview of prevalence, diagnosis, pathogenesis and treatment considerations. Clin Sci (Lond) 2008 115 : 141 150.
    • (2008) Clin Sci (Lond) , vol.115 , pp. 141-150
    • Preiss, D.1    Sattar, N.2
  • 3
    • 48449103834 scopus 로고    scopus 로고
    • Review article: Diagnosis and treatment of non-alcoholic fatty liver disease
    • Oh MK, Winn J, Poordad F. Review article: Diagnosis and treatment of non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2008 28 : 503 522.
    • (2008) Aliment Pharmacol Ther , vol.28 , pp. 503-522
    • Oh, M.K.1    Winn, J.2    Poordad, F.3
  • 4
    • 44949241314 scopus 로고    scopus 로고
    • Consensus recommendations for managing asymptomatic persistent non-virus non-alcohol related elevation of aminotransferase levels: Suggestions for diagnostic procedures and monitoring
    • Morisco F, Pagliaro L, Caporaso N, et al. Consensus recommendations for managing asymptomatic persistent non-virus non-alcohol related elevation of aminotransferase levels: Suggestions for diagnostic procedures and monitoring. Dig Liver Dis 2008 40 : 585 598.
    • (2008) Dig Liver Dis , vol.40 , pp. 585-598
    • Morisco, F.1    Pagliaro, L.2    Caporaso, N.3
  • 5
    • 42949154244 scopus 로고    scopus 로고
    • Diagnosis and therapy of nonalcoholic steatohepatitis
    • Torres DM, Harrison SA. Diagnosis and therapy of nonalcoholic steatohepatitis. Gastroenterology 2008 134 : 1682 1698.
    • (2008) Gastroenterology , vol.134 , pp. 1682-1698
    • Torres, D.M.1    Harrison, S.A.2
  • 7
    • 0034048191 scopus 로고    scopus 로고
    • Defining patient risks from expanded preventive therapies
    • Tolman KG. Defining patient risks from expanded preventive therapies. Am J Cardiol 2000 85 (12A 15E 19E.
    • (2000) Am J Cardiol , vol.85 , Issue.12
    • Tolman, K.G.1
  • 9
    • 0037463823 scopus 로고    scopus 로고
    • Safety and statin therapy: Reconsidering the risks and benefits
    • Gotto AM Jr. Safety and statin therapy: Reconsidering the risks and benefits. Arch Intern Med 2003 163 : 657 659.
    • (2003) Arch Intern Med , vol.163 , pp. 657-659
    • Gotto, Jr.A.M.1
  • 10
    • 16244384606 scopus 로고    scopus 로고
    • Statins and hepatotoxicity: Focus on patients with fatty liver
    • Chalasani N. Statins and hepatotoxicity: Focus on patients with fatty liver. Hepatology 2005 41 : 690 695.
    • (2005) Hepatology , vol.41 , pp. 690-695
    • Chalasani, N.1
  • 11
    • 25844453682 scopus 로고    scopus 로고
    • Joint Formulary Committee editor. London: British Medical Association and Royal Pharmaceutical Society of Great Britain
    • Joint Formulary Committee editor. British National Formulary. 54th ed. London : British Medical Association and Royal Pharmaceutical Society of Great Britain, 2007.
    • (2007) British National Formulary. 54th Ed.
  • 12
    • 33645870418 scopus 로고    scopus 로고
    • Statin safety: Lessons from new drug applications for marketed statins
    • Jacobson TA. Statin safety: Lessons from new drug applications for marketed statins. Am J Cardiol 2006 97 (8A 44C 51C.
    • (2006) Am J Cardiol , vol.97 , Issue.8
    • Jacobson, T.A.1
  • 13
    • 7044272752 scopus 로고    scopus 로고
    • Is there value in liver function test and creatine phosphokinase monitoring with statin use
    • Sniderman AD. Is there value in liver function test and creatine phosphokinase monitoring with statin use Am J Cardiol 2004 94 (9A 30F 34F.
    • (2004) Am J Cardiol , vol.94 , Issue.9
    • Sniderman, A.D.1
  • 14
    • 0037097465 scopus 로고    scopus 로고
    • The liver and lovastatin
    • Tolman KG. The liver and lovastatin. Am J Cardiol 2002 89 : 1374 1380.
    • (2002) Am J Cardiol , vol.89 , pp. 1374-1380
    • Tolman, K.G.1
  • 15
    • 33645888317 scopus 로고    scopus 로고
    • An assessment of statin safety by hepatologists
    • National Lipid Association Statin Safety Task Force Liver Expert Panel.
    • Cohen DE, Anania FA, Chalasani N, National Lipid Association Statin Safety Task Force Liver Expert Panel. An assessment of statin safety by hepatologists. Am J Cardiol 2006 97 (8A 77C 81C.
    • (2006) Am J Cardiol , vol.97 , Issue.8
    • Cohen, D.E.1    Anania, F.A.2    Chalasani, N.3
  • 16
    • 33645889332 scopus 로고    scopus 로고
    • Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force
    • National Lipid Association Statin Safety Assessment Task Force.
    • McKenney JM, Davidson MH, Jacobson TA, Guyton JR, National Lipid Association Statin Safety Assessment Task Force. Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force. Am J Cardiol 2006 97 (8A 89C 94C.
    • (2006) Am J Cardiol , vol.97 , Issue.8
    • McKenney, J.M.1    Davidson, M.H.2    Jacobson, T.A.3    Guyton, J.R.4
  • 17
    • 9744257865 scopus 로고    scopus 로고
    • Statin treatment in diabetes mellitus
    • Buse J. Statin treatment in diabetes mellitus. Clin Diabetes 2003 21 : 168 172.
    • (2003) Clin Diabetes , vol.21 , pp. 168-172
    • Buse, J.1
  • 19
    • 19544375388 scopus 로고    scopus 로고
    • Evaluation of cases of severe statin-related transaminitis within a large health maintenance organization
    • Charles EC, Olson KL, Sandhoff BG, McClure DL, Merenich JA. Evaluation of cases of severe statin-related transaminitis within a large health maintenance organization. Am J Med 2005 118 : 618 624.
    • (2005) Am J Med , vol.118 , pp. 618-624
    • Charles, E.C.1    Olson, K.L.2    Sandhoff, B.G.3    McClure, D.L.4    Merenich, J.A.5
  • 20
    • 15444368643 scopus 로고    scopus 로고
    • Drug-induced hepatotoxicity: 2005
    • Maddrey WC. Drug-induced hepatotoxicity: 2005. J Clin Gastroenterol 2005 39 (4 Suppl 2 S83 S89.
    • (2005) J Clin Gastroenterol , vol.39 , Issue.42
    • Maddrey, W.C.1
  • 21
    • 0037097447 scopus 로고    scopus 로고
    • Side effects of statins: Hepatitis versus "transaminitis"- myositis versus "cPKitis"
    • Dujovne CA. Side effects of statins: Hepatitis versus "transaminitis"-myositis versus "CPKitis". Am J Cardiol 2002 89 : 1411 1413.
    • (2002) Am J Cardiol , vol.89 , pp. 1411-1413
    • Dujovne, C.A.1
  • 22
    • 2142768218 scopus 로고    scopus 로고
    • Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity
    • Chalasani N, Aljadhey H, Kesterson J, Murray MD, Hall SD. Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity. Gastroenterology 2004 126 : 1287 1292.
    • (2004) Gastroenterology , vol.126 , pp. 1287-1292
    • Chalasani, N.1    Aljadhey, H.2    Kesterson, J.3    Murray, M.D.4    Hall, S.D.5
  • 23
    • 13844255081 scopus 로고    scopus 로고
    • Patients with elevated baseline liver enzymes do not have higher frequency of hepatotoxicity from lovastatin than those with normal baseline liver enzymes
    • Vuppalanchi R, Teal E, Chalasani N. Patients with elevated baseline liver enzymes do not have higher frequency of hepatotoxicity from lovastatin than those with normal baseline liver enzymes. Am J Med Sci 2005 329 : 62 65.
    • (2005) Am J Med Sci , vol.329 , pp. 62-65
    • Vuppalanchi, R.1    Teal, E.2    Chalasani, N.3
  • 24
    • 2342456307 scopus 로고    scopus 로고
    • Pravastatin in patients with nonalcoholic steatohepatitis: Results of a pilot study
    • Rallidis LS, Drakoulis CK, Parasi AS. Pravastatin in patients with nonalcoholic steatohepatitis: Results of a pilot study. Atherosclerosis 2004 174 : 193 196.
    • (2004) Atherosclerosis , vol.174 , pp. 193-196
    • Rallidis, L.S.1    Drakoulis, C.K.2    Parasi, A.S.3
  • 25
    • 34249342305 scopus 로고    scopus 로고
    • Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: A histopathological follow-up study
    • Ekstedt M, Franzen LE, Mathiesen UL, Holmqvist M, Bodemar G, Kechagias S. Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: A histopathological follow-up study. J Hepatol 2007 47 : 135 141.
    • (2007) J Hepatol , vol.47 , pp. 135-141
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3    Holmqvist, M.4    Bodemar, G.5    Kechagias, S.6
  • 26
    • 34047271926 scopus 로고    scopus 로고
    • Therapeutic options in non-alcoholic steatohepatitis (NASH). Are all agents alike Results of a preliminary study
    • Georgescu EF, Georgescu M. Therapeutic options in non-alcoholic steatohepatitis (NASH). Are all agents alike Results of a preliminary study. J Gastrointestin Liver Dis 2007 16 : 39 46.
    • (2007) J Gastrointestin Liver Dis , vol.16 , pp. 39-46
    • Georgescu, E.F.1    Georgescu, M.2
  • 27
    • 0347917155 scopus 로고    scopus 로고
    • Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis
    • Kiyici M, Gulten M, Gurel S, et al. Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis. Can J Gastroenterol 2003 17 : 713 718.
    • (2003) Can J Gastroenterol , vol.17 , pp. 713-718
    • Kiyici, M.1    Gulten, M.2    Gurel, S.3
  • 28
    • 4344593276 scopus 로고    scopus 로고
    • Efficacy of omega-3 fatty acids, atorvastatin and orlistat in non-alcoholic fatty liver disease with dyslipidemia
    • Hatzitolios A, Savopoulos C, Lazaraki G, et al. Efficacy of omega-3 fatty acids, atorvastatin and orlistat in non-alcoholic fatty liver disease with dyslipidemia. Indian J Gastroenterol 2004 23 : 131 134.
    • (2004) Indian J Gastroenterol , vol.23 , pp. 131-134
    • Hatzitolios, A.1    Savopoulos, C.2    Lazaraki, G.3
  • 30
    • 28344436469 scopus 로고    scopus 로고
    • Rosuvastatin as a novel treatment of non-alcoholic fatty liver disease in hyperlipidemic patients
    • Antonopoulos S, Mikros S, Mylonopoulou M, Kokkoris S, Giannoulis G. Rosuvastatin as a novel treatment of non-alcoholic fatty liver disease in hyperlipidemic patients. Atherosclerosis 2006 184 : 233 234.
    • (2006) Atherosclerosis , vol.184 , pp. 233-234
    • Antonopoulos, S.1    Mikros, S.2    Mylonopoulou, M.3    Kokkoris, S.4    Giannoulis, G.5
  • 31
    • 33646410075 scopus 로고    scopus 로고
    • The effects of statins on high-density lipoproteins
    • Schaefer EJ, Asztalos BF. The effects of statins on high-density lipoproteins. Curr Atheroscler Rep 2006 8 : 41 49.
    • (2006) Curr Atheroscler Rep , vol.8 , pp. 41-49
    • Schaefer, E.J.1    Asztalos, B.F.2
  • 32
    • 0033055916 scopus 로고    scopus 로고
    • Fatty liver - An additional and treatable feature of the insulin resistance syndrome
    • Knobler H, Schattner A, Zhornicki T, et al. Fatty liver - An additional and treatable feature of the insulin resistance syndrome. QJM 1999 92 : 73 79.
    • (1999) QJM , vol.92 , pp. 73-79
    • Knobler, H.1    Schattner, A.2    Zhornicki, T.3
  • 33
    • 0031783925 scopus 로고    scopus 로고
    • Fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, scavenges free radicals and inhibits lipid peroxidation in rat liver microsomes
    • Yamamoto A, Hoshi K, Ichihara K. Fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, scavenges free radicals and inhibits lipid peroxidation in rat liver microsomes. Eur J Pharmacol 1998 361 : 143 149.
    • (1998) Eur J Pharmacol , vol.361 , pp. 143-149
    • Yamamoto, A.1    Hoshi, K.2    Ichihara, K.3
  • 34
    • 0037319739 scopus 로고    scopus 로고
    • Statin effects beyond lipid lowering - Are they clinically relevant
    • Bonetti PO, Lerman LO, Napoli C, Lerman A. Statin effects beyond lipid lowering - Are they clinically relevant Eur Heart J 2003 24 : 225 248.
    • (2003) Eur Heart J , vol.24 , pp. 225-248
    • Bonetti, P.O.1    Lerman, L.O.2    Napoli, C.3    Lerman, A.4
  • 35
    • 0030814892 scopus 로고    scopus 로고
    • Mevalonate-dependent inhibition of transendothelial migration and chemotaxis of human peripheral blood neutrophils by pravastatin
    • Dunzendorfer S, Rothbucher D, Schratzberger P, Reinisch N, Kahler CM, Wiedermann CJ. Mevalonate-dependent inhibition of transendothelial migration and chemotaxis of human peripheral blood neutrophils by pravastatin. Circ Res 1997 81 : 963 969.
    • (1997) Circ Res , vol.81 , pp. 963-969
    • Dunzendorfer, S.1    Rothbucher, D.2    Schratzberger, P.3    Reinisch, N.4    Kahler, C.M.5    Wiedermann, C.J.6
  • 36
    • 33644657697 scopus 로고    scopus 로고
    • Safety of statins: Effects on muscle and the liver
    • Vasudevan AR, Hamirani YS, Jones PH. Safety of statins: Effects on muscle and the liver. Cleve Clin J Med 2005 72 : 990 993, 996 1001.
    • (2005) Cleve Clin J Med , vol.72 , pp. 990-993
    • Vasudevan, A.R.1    Hamirani, Y.S.2    Jones, P.H.3
  • 37
    • 7744220837 scopus 로고    scopus 로고
    • Prescription of statins to dyslipidemic patients affected by liver diseases: A subtle balance between risks and benefits
    • Anfossi G, Massucco P, Bonomo K, Trovati M. Prescription of statins to dyslipidemic patients affected by liver diseases: A subtle balance between risks and benefits. Nutr Metab Cardiovasc Dis 2004 14 : 215 224.
    • (2004) Nutr Metab Cardiovasc Dis , vol.14 , pp. 215-224
    • Anfossi, G.1    Massucco, P.2    Bonomo, K.3    Trovati, M.4
  • 38
    • 34548190309 scopus 로고    scopus 로고
    • Lipid-lowering agents that cause drug-induced hepatotoxicity
    • Bhardwaj SS, Chalasani N. Lipid-lowering agents that cause drug-induced hepatotoxicity. Clin Liver Dis 2007 11 : 597 613.
    • (2007) Clin Liver Dis , vol.11 , pp. 597-613
    • Bhardwaj, S.S.1    Chalasani, N.2
  • 39
    • 33947284587 scopus 로고    scopus 로고
    • Asia-Pacific Working Party on NAFLD. How should we manage patients with non-alcoholic fatty liver disease in 2007
    • Chan HL, de Silva HJ, Leung NW, Lim SG, Farrell GC, Asia-Pacific Working Party on NAFLD. How should we manage patients with non-alcoholic fatty liver disease in 2007 J Gastroenterol Hepatol 2007 22 : 801 808.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 801-808
    • Chan, H.L.1    De Silva, H.J.2    Leung, N.W.3    Lim, S.G.4    Farrell, G.C.5
  • 40
    • 0028122866 scopus 로고
    • Acute hepatitis induced by HMG-CoA reductase inhibitor, lovastatin
    • Grimbert S, Pessayre D, Degott C, Benhamou JP. Acute hepatitis induced by HMG-CoA reductase inhibitor, lovastatin. Dig Dis Sci 1994 39 : 2032 2033.
    • (1994) Dig Dis Sci , vol.39 , pp. 2032-2033
    • Grimbert, S.1    Pessayre, D.2    Degott, C.3    Benhamou, J.P.4
  • 41
    • 0033135964 scopus 로고    scopus 로고
    • Acute cholestatic hepatitis associated with pravastatin
    • Hartleb M, Rymarczyk G, Januszewski K. Acute cholestatic hepatitis associated with pravastatin. Am J Gastroenterol 1999 94 : 1388 1390.
    • (1999) Am J Gastroenterol , vol.94 , pp. 1388-1390
    • Hartleb, M.1    Rymarczyk, G.2    Januszewski, K.3
  • 42
    • 0033546901 scopus 로고    scopus 로고
    • Cholestatic liver dysfunction
    • Wierzbicki AS, Crook MA. Cholestatic liver dysfunction. Lancet 1999 354 : 954.
    • (1999) Lancet , vol.354 , pp. 954
    • Wierzbicki, A.S.1    Crook, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.