Obesity and Respiratory Diseases in Childhood

Clinics in Chest Medicine

Volumn 30, Issue 3, 2009, Pages 601-608

  Fiorino, Elizabeth K ^a   Brooks, Lee J ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Asthma; Children; Obesity; Obesity hypoventilation syndrome; Pulmonary mechanics; Sleep apnea

Indexed keywords

ANESTHETIC AGENT; BENZODIAZEPINE DERIVATIVE; BRONCHODILATING AGENT;

ADENOTONSILLECTOMY; ASTHMA; BODY MASS; CHILD; CHILDHOOD DISEASE; CHRONIC INFLAMMATION; COMORBIDITY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; EXPIRATORY RESERVE VOLUME; FITNESS; FUNCTIONAL RESIDUAL CAPACITY; GASTRIC BANDING; HEART DISEASE; HIGH RISK PATIENT; HUMAN; HYPERCAPNIA; HYPOXIA; LUNG FUNCTION; LUNG FUNCTION TEST; LUNG MECHANICS; LUNG VOLUME; METABOLIC SYNDROME X; MORBID OBESITY; MORBIDITY; NONHUMAN; OBESITY; OBESITY HYPOVENTILATION SYNDROME; PATHOPHYSIOLOGY; PERIOPERATIVE PERIOD; POLYSOMNOGRAPHY; POSITIVE END EXPIRATORY PRESSURE; PREVALENCE; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; REVIEW; SLEEP APNEA SYNDROME; THORAX WALL; TREATMENT OUTCOME; VASCULAR DISEASE; WEIGHT REDUCTION;

ADOLESCENT; ASTHMA; CHILD; CHILD, PRESCHOOL; HUMANS; OBESITY; OBESITY HYPOVENTILATION SYNDROME; RESPIRATORY MECHANICS; SLEEP APNEA, OBSTRUCTIVE;

EID: 68849098500     PISSN: 02725231     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccm.2009.05.010     Document Type: Review

References (76)

1. Strauss R.S., and Pollack H.A. Epidemic increase in childhood overweight. JAMA 286 22 (2001) 2845-2848
2. Ogden C.L., Carroll M.D., Curtin L.R., et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 295 13 (2006) 1549-1555
3. Chernick V., Boat T.F., Wilmott R.W., et al. Kendig's disorders of the respiratory tract in children (2006), Elsevier, Philadelphia
4. Wang G., and Dietz W.H. Economic burden of obesity in youths aged 6 to 17 years: 1979-1999. Pediatrics 109 (2002) e81
5. Shore S.A. Obesity and asthma: lessons from animal models. J Appl Physiol 102 (2007) 516-528
6. Jones R.L., and Nzekwu M.U. The effects of body mass index on lung volumes. Chest 130 3 (2006) 827-833
7. Ray C.S., Sue D.Y., Bray G., et al. Effects of obesity on respiratory function. Am Rev Respir Dis 128 (1983) 501-506
8. Wang L., and Cerny F.J. Ventilatory response to exercise in simulated obesity by chest loading. Med Sci Sports Exerc 35 (2004) 780-786
9. Wang X., Dockery D., Wypij D., et al. Pulmonary function between 6 and 18 years of age. Pediatr Pulmonol 15 (1993) 75-88
10. Marcus C., Curtis S., Koerner C., et al. Evaluation of pulmonary function and polysomnography in obese children and adolescents. Pediatr Pulmonol 21 (1996) 176-183
11. Lazarus R.L., Colditz G., Berkey C.S., et al. Effects of body fat on ventilatory function in children and adolescents: cross-sectional findings from a random population sample of school children. Pediatr Pulmonol 24 3 (1997) 187-194
12. Li A.M., Chan D., Wong E., et al. The effects of obesity on pulmonary function. Arch Dis Child 88 (2003) 361-363
13. von Mutius E., Schwartz J., Neas L.M., et al. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax 56 (2001) 835-838
14. Brenner J.S., Kelly C.S., Wenger A.D., et al. Asthma and obesity in adolescents: is there an association?. J Asthma 38 6 (2001) 509-515
15. Leung T.F., Li C.Y., Lam C.W., et al. The relation between obesity and asthmatic airway inflammation. Pediatr Allergy Immunol 15 4 (2004) 344-350
16. Mansell A.L., Walders N., Wamboldt M.Z., et al. Effect of body mass index on response to methacholine bronchial provocation in healthy and asthmatic adolescents. Pediatr Pulmonol 41 (2006) 434-440
17. Flaherman V., and Rutherford G.W. A meta-analysis of the effect of high weight on asthma. Arch Dis Child 91 (2006) 334-339
18. Chinn S., and Rona R.J. Can the increase in body mass index explain the rising trend in asthma in children?. Thorax 56 (2001) 845-850
19. Visness C.M., London S.J., Daniels J.L., et al. Association of obesity with IgE levels and allergy symptoms in children and adolescents: results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immunol 123 5 (2009) 1163-1169
20. Huang S.L., Shiao G., and Chou P. Association between body mass index and allergy in teenage girls in Taiwan. Clin Exp Allergy 29 3 (1999) 323-329
21. Schachter L.M., Peat J.K., and Salome C.M. Asthma and atopy in overweight children. Thorax 58 12 (2003) 1031-1035
22. Hancox R.J., Milne B.J., Pouton R., et al. Sex differences in the relation between body mass index and asthma and atopy in a birth cohort. Am J Respir Crit Care Med 171 5 (2005) 440-445
23. VanGysel D., Govaere E., Verhamme K., et al. Body mass index in Belgian schoolchildren and its relationship with sensitization and allergic symptoms. Pediatr Allergy Immunol (2008) [Epub ahead of print]. DOI:10.1111/j.1399-3038.2008.00774.x
24. Carroll C.L., Bhandari A., Zucker A.R., et al. Childhood obesity increases duration of therapy during severe asthma exacerbations. Pediatr Crit Care Med 7 (2006) 527-531
25. Pianosi P.T., and Davis H.S. Determinants of physical fitness in children with asthma. Pediatrics 113 3 Pt 1 (2004) e225-e229
26. Belamarich F., Luder E., Kattan M., et al. Do obese inner-city children with asthma have more symptoms than nonobese children with asthma?. Pediatrics 106 (2000) 1436-1441
27. Sulit L.G., Storfer-Iser A., Rosen C.L., et al. Associations of obesity, sleep-disordered breathing, and wheezing in children. Am J Respir Crit Care Med 171 (2005) 659-664
28. Glazebrook C., McPherson A.C., Macdonald I.A., et al. Asthma as a barrier to children's physical activity: implications for body mass index and mental health. Pediatrics 118 (2006) 2443-2449
29. van Gent R., van der Ent C.K., Rovers M.M., et al. Excessive body weight is associated with additional loss of quality of life in children with asthma. J Allergy Clin Immunol 119 3 (2007) 591-596
30. Fredberg J.F., Inouye D.S., Mijailovich S.M., et al. Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm. Am J Respir Crit Care Med 159 (1999) 959-967
31. Fredberg J.J. Bronchospasm and its biophysical basis in airway smooth muscle. Available at:. Respir Res (2004). http://respiratory-research.com/content/5/1/2
32. Friedenberg F.K., Xanthopoulos M., Foster G.D., et al. The association between gastroesophageal reflux disease and obesity. Am J Gastroenterol 103 (2008) 2111-2122
33. Størdal K., Johannesdottir G.B., Bentsen B.S., et al. Asthma and overweight are associated with symptoms of gastro-oesophageal reflux. Acta Paediatr 95 10 (2006) 1197-1201
34. Pashankar D.S., Corbin Z., Shah S.K., et al. Increased prevalence of gastroesophageal reflux symptoms in obese children evaluated in an academic medical center. J Clin Gastroenterol (2008 Dec 18) [Epub ahead of print]
35. Bergen H.T., Cherlet T.C., Manuel P., et al. Identification of leptin receptors in lung and isolated fetal type II cells. Am J Respir Cell Mol Biol 27 (2002) 71-77
36. Torday J.S., Sun H., Wang L., et al. Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. Am J Physiol Lung Cell Mol Physiol 282 (2002) L405-L410
37. Guler N., Kirerleri E., Ones U., et al. Leptin: does it have any role in childhood asthma?. J Allergy Clin Immunol 114 (2004) 254-259
38. Mai X.M., Bottcher M.F., and Leijon I. Leptin and asthma in overweight children at 12 years of age. Pediatr Allergy Immunol 15 6 (2004) 523-530
39. Shin J.H., Kim J.H., Lee W.Y., et al. The expression of adiponectin receptors and the effects of adiponectin and leptin on airway smooth muscle cells. Yonsei Med J 49 5 (2008) 804-810
40. Shore S.A., Terry R.D., Flynt L., et al. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 118 (2006) 389-395
41. Rothenbacher D., Weyermann M., Fantuzzi G., et al. Adipokines in cord blood and risk of wheezing disorders within the first two years of life. Clin Exp Allergy 37 8 (2007) 1143-1149
42. Nagel G., Koenig W., Rapp K., et al. Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Pediatr Allergy Immunol 20 (2009) 81-88
43. Nemet D., Wang P., Funahashi T., et al. Adipocytokines, body composition, and fitness in children. Pediatr Res 53 1 (2003) 148-152
44. Kim K.W., Shin Y.H., Lee K.E., et al. Relationship between adipokines and manifestations of childhood asthma. Pediatr Allergy Immunol 19 (2008) 535-540
45. Yitzhak A., Mizrahi S., and Avinoach E. Laparoscopic gastric banding in adolescents. Obes Surg 16 10 (2006) 1318-1322
46. Simpser M.D., Strieder D.J., Wohl M.E., et al. Sleep apnea in a child with the pickwickian syndrome. Pediatrics 60 3 (1977) 290-293
47. Stool S.E., Eavey R.D., Stein S.L., et al. The "chubby puffer" syndrome. Upper airway obstruction and obesity, with intermittent somnolence and cardiorespiratory embarrassment. Clin Pediatr 16 1 (1977) 43-50
48. Brouillette R.T., Fernbach S.K., and Hunt C.E. Obstructive sleep apnea in infants and children. J Pediatr 100 1 (1982) 31-40
49. Mallory Jr. G.B., Fiser D.H., and Jackson R. Sleep-associated breathing disorders in morbidly obese children and adolescents. J Pediatr 115 6 (1989) 892-897
50. Silvestri J.M., Weese-Mayer D.E., Bass M.T., et al. Polysomnography in obese children with a history of sleep associated breathing disorders. Pediatr Pulmonol 16 2 (1993) 124-129
51. Brooks L.J., Stephens B.M., and Bacevice A.M. Adenoid size is related to severity but not the number of episodes of obstructive apnea in children. J Pediatr 132 4 (1998) 682-686
52. Redline S., Tishler P.V., Schluchter S., et al. Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med 159 5 Pt 1 (1999) 1527-1532
53. Bandla P., Brooks L.J., Trimarchi T., et al. Obstructive sleep apnea in children. Anesthesiology Clin N Am 23 (2005) 535-549
54. Horner R.L., Mohiaddin R.H., Lowell D.G., et al. Sites and sizes of fat deposits around the pharynx in obese patients with obstructive sleep apnoea and weight matched controls. Eur Respir J 2 7 (1989) 613-622
55. Suratt P.M., Dee P., Atkinson R.L., et al. Fluoroscopic and computed tomographic features of the pharyngeal airway in obstructive sleep apnea. Am Rev Respir Dis 127 4 (1983) 487-492
56. Isono S., Shimada A., Utsugi M., et al. Comparison of static mechanical properties of the passive pharynx between normal children and children with sleep-disordered breathing. Am J Respir Crit Care Med 157 4 Pt 1 (1998) 1204-1212
57. Arens R., and Marcus C.L. Pathophysiology of upper airway obstruction: a developmental perspective. Sleep 27 5 (2004) 997-1018
58. Fregosi R.F., Quan S.F., Kaemingk K.L., et al. Sleep-disordered breathing, pharyngeal size, and soft tissue anatomy in children. J Appl Physiol 95 (2003) 2030-2038
59. Rosen C.L. Clinical features of obstructive sleep apnea hypoventilation syndrome in otherwise healthy children. Pediatr Pulmonol 27 6 (1999) 403-409
60. Keens T.G., and Ward S.L.D. Syndromes affecting respiratory control during sleep. In: Loughlin G.M., Carroll J.L., and Marcus C.L. (Eds). Sleep and breathing in children: a developmental approach (2000), Maracel Dekker, New York 525-553
61. Gozal D., and Kheirandish-Gozal L. Obesity and excessive daytime sleepiness in prepubertal children with obstructive sleep apnea. Pediatrics 123 1 (2009) 13-18
62. Vgontzas A.N., Papanicolau D.A., Bixler E.O., et al. Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab 82 5 (1997) 1313-1316
63. Brooks L.J., Chng S.Y., Marcus C.L., et al. Blood pressure, sleep, and sleep disordered breathing in children [abstract]. Am J Respir Crit Care Med 177 (2008) A705
64. Leung L.C., Ng D.K., Lau M.W., et al. Twenty-four hour ambulatory BP in snoring children with obstructive sleep apnea syndrome. Chest 130 4 (2006) 1009-1017
65. Reade E.P., Whaley C., Lin J.J., et al. Hypopnea in pediatric patients with obesity hypertension. Pediatr Nephrol 19 9 (2004) 1014-1020
66. Li A.M., Au C.T., Sung R.Y., et al. Ambulatory blood pressure in children with obstructive sleep apnoea: a community based study. Thorax 63 9 (2008) 803-809
67. Suen J.S., Arnold J.E., and Brooks L.J. Adenotonsillectomy for treatment of obstructive sleep apnea in children. Arch Otolaryngol Head Neck Surg 121 5 (1995) 525-530
68. Kudoh F., and Sanai A. Effect of tonsillectomy and adenoidectomy on obese children with sleep-associated breathing disorders. Acta Otolaryngol Suppl 523 (1996) 216-218
69. Morton S., Rosen C., Larkin E., et al. Predictors of sleep-disordered breathing in children with a history of tonsillectomy and adenoidectomy. Sleep 24 7 (2001) 823-829
70. O'Brien L.M., Sitha S., Baur L.A., et al. Obesity increases the risk for persisting obstructive sleep apnea after treatment in children. Int J Pediatr Otorhinolaryngol 70 (2006) 1555-1560
71. Apostolidou M.T., Alexopoulos E.I., Chaidas K., et al. Obesity and persisting sleep apnea after adenotonsillectomy in Greek children. Chest 134 (2008) 1149-1155
72. Nafiu O.O., Reynolds P.I., Bamgbade O.A., et al. Childhood body mass index and perioperative complications. Paediatr Anaesth 17 5 (2007) 426-430
73. Tait A.R., Voepel-Lewis T., Burke C., et al. Incidence and risk factors for perioperative adverse respiratory events in children who are obese. Anesthesiology 108 3 (2008) 375-380
74. Singh A.S., Mulder C., Twisk J.W., et al. Tracking of childhood overweight into adulthood: a systematic review of the literature. Obes Rev 9 5 (2008) 474-488
75. Redline S., Storfer-Isser A., Rosen C.L., et al. Association between metabolic syndrome and sleep disordered breathing in adolescents. Am J Respir Crit Care Med 176 4 (2007) 401-408
76. Verhulst S.L., Schrauwen N., Haentjens D., et al. Sleep-disordered breathing and the metabolic syndrome in overweight and obese children and adolescents. J Pediatr 150 6 (2007) 612-616