Generation and functional characterization of mice with a conditional BMP7 allele

International Journal of Developmental Biology

Volumn 53, Issue 4, 2009, Pages 597-603

  Zouvelou, Vasiliki ^a   Passa, Ourania ^a   Segklia, Katerina ^a   Tsalavos, Sotiris ^a   Valenzuela, David M ^b   Economides, Aris N ^b   Graf, Daniel ^a  

^a BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING   (Greece)

^b REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

Bacterial homologous recombination; Bone morphogenetic protein; Cre LoxP; Gene targeting

Indexed keywords

CRE RECOMBINASE; OSTEOGENIC PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; DNA FLANKING REGION; EMBRYO; EMBRYONIC STEM CELL; EXON; FEMALE; GENE TARGETING; HOMEOSTASIS; HOMOLOGOUS RECOMBINATION; IN VIVO STUDY; LOXP SITE; MOUSE; NONHUMAN; NULL ALLELE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; WILD TYPE; ALLELE; ANIMAL; ANIMAL EMBRYO; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETICS; KIDNEY; METABOLISM; METHODOLOGY; PHENOTYPE; PRENATAL DEVELOPMENT; TRANSGENIC MOUSE;

BACTERIA (MICROORGANISMS); MUS;

ALLELES; ANIMALS; BONE MORPHOGENETIC PROTEIN 7; EMBRYO, MAMMALIAN; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC ENGINEERING; KIDNEY; MICE; MICE, TRANSGENIC; PHENOTYPE;

EID: 68849095265     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: 10.1387/ijdb.082648vz     Document Type: Article

References (20)

1. ADAMS, D., KAROLAK, M., ROBERTSON, E. and OXBURGH, L. (2007). Control of kidney, eye and limb expression of Bmp7 by an enhancer element highly conserved between species. Dev Biol 311: 679-690.
2. ARA, J., SEE, J., MAMONTOV, P., HAHN, A., BANNERMAN, P., PLEASURE, D. and GRINSPAN, J.B. (2008). Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis. J Neurosci Res 86: 125-135.
3. DE BOER, J., WILLIAMS, A., SKAVDIS, G., HARKER, N., COLES, M., TOLAINI, M., NORTON, T., WILLIAMS, K., RODERICK, K., POTOCNIK, A.J. et al. (2003). Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur J Immunol 33: 314-325.
4. DUDLEY, A.T., LYONS, K.M. and ROBERTSON, E.J. (1995). A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 9: 2795-2807.
5. FARLEY, F.W., SORIANO, P., STEFFEN, L.S. and DYMECKI, S.M. (2000). Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28: 106-110.
6. GODIN, R.E., TAKAESU, N.T., ROBERTSON, E.J. and DUDLEY, A.T. (1998). Regulation of BMP7 expression during kidney development. Development 125: 3473-3482.
7. GRAF, D., NETHISINGHE, S., PALMER, D.B., FISHER, A.G. and MERKENSCHLAGER, M. (2002). The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development. J Exp Med 196: 163-171.
8. JENA, N., MARTIN-SEISDEDOS, C., MCCUE, P. and CROCE, C.M. (1997). BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye. Exp Cell Res 230: 28-37.
9. JONES, W.K., RICHMOND, E.A., WHITE, K., SASAK, H., KUSMIK, W., SMART, J., OPPERMANN, H., RUEGER, D.C. and TUCKER, R.F. (1994). Osteogenic protein-1 (OP-1) expression and processing in Chinese hamster ovary cells: isolation of a soluble complex containing the mature and pro-domains of OP-1. Growth Factors 11: 215-225.
10. LORIES, R.J. and LUYTEN, F.P. (2005). Bone morphogenetic protein signaling in joint homeostasis and disease. Cytokine Growth Factor Rev 16: 287-298.
11. LUO, G., HOFMANN, C., BRONCKERS, A.L., SOHOCKI, M., BRADLEY, A. and KARSENTY, G. (1995). BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev 9: 2808-2820.
12. MUYRERS, J.P., ZHANG, Y., TESTA, G. and STEWART, A.F. (1999). Rapid modification of bacterial artificial chromosomes by ET-recombination. Nucleic Acids Res 27: 1555-1557.
13. OZKAYNAK, E., SCHNEGELSBERG, P.N., JIN, D.F., CLIFFORD, G.M., WARREN, F.D., DRIER, E.A. and OPPERMANN, H. (1992). Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis. J Biol Chem 267: 25220-25227.
14. PATEL, S.R. and DRESSLER, G.R. (2005). BMP7 signaling in renal development and disease. Trends Mol Med 11: 512-518.
15. SANCHO, E., BATLLE, E. and CLEVERS, H. (2004). Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol 20: 695-723.
16. SCHWENK, F., BARON, U. and RAJEWSKY, K. (1995). A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res 23: 5080-5081.
17. SIMIC, P. and VUKICEVIC, S. (2005). Bone morphogenetic proteins in development and homeostasis of kidney. Cytokine Growth Factor Rev 16: 299-308.
18. VALENZUELA, D.M., MURPHY, A.J., FRENDEWEY, D., GALE, N.W., ECONOMIDES, A.N., AUERBACH, W., POUEYMIROU, W.T., ADAMS, N.C., ROJAS, J., YASENCHAK, J. et al. (2003). High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol 21: 652-659.
19. ZEISBERG, M., YANG, C., MARTINO, M., DUNCAN, M.B., RIEDER, F., TANJORE, H. and KALLURI, R. (2007). Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 282: 23337-23347.
20. ZOUVELOU, V., LUDER, H.U., MITSIADIS, T. and GRAF, D. (2009). Deletion of BMP7 affects the development of bones, teeth, and other ectodermal appendages of the orofacial complex J Exp Zoolog B Mol Dev Evol (in press).