Direct asymmetric reductive amination

Journal of the American Chemical Society

Volumn 131, Issue 32, 2009, Pages 11316-11317

  Steinhuebel, Dietrich ^a   Sun, Yongkui ^a   Matsumura, Kazuhiko ^b   Sayo, Noboru ^b   Saito, Takao ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b TAKASAGO INTERNATIONAL CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM IONS; CHEMICAL EQUATIONS; CHEMO-SELECTIVITY; CHIRAL CATALYST; HIGH CONCENTRATION; HIGH ENANTIOSELECTIVITY; HIGH YIELD; ONE POT; REACTION EFFICIENCY; REDUCTIVE AMINATION; RU CATALYSTS; SEGPHOS;

AMIDES; AMINATION; AMMONIUM COMPOUNDS; CATALYSIS; CATALYSTS; ENANTIOSELECTIVITY;

AMINES;

AMMONIA; BETA AMINO ACID; BETA AMINO AMIDE; BETA KETO AMIDE; RUTHENIUM; SITAGLIPTIN; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; CATALYST; CHEMICAL REACTION; CHIRALITY; CONCENTRATION (PARAMETERS); ENANTIOSELECTIVITY; HYDROGENATION; ONE POT SYNTHESIS;

AMIDES; AMINATION; CATALYSIS; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; RUTHENIUM COMPOUNDS; STEREOISOMERISM;

EID: 68849088073     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja905143m     Document Type: Article

References (19)

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18. The use of ammonium benzoate and formate gave lower yields (19 and 42%, respectively).
19. High yields and ee's were also observed using several other bisphosphine chiral ligands, such as BINAP (85% yield, 99.1% ee), xyl-binap (90% yield, 98.0% ee), and SEGPHOS (80% yield, 99.8% ee).